2022
DOI: 10.1101/2022.07.29.498756
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Acrylamide Induces Protein Aggregation in CNS through Suppression of FoxO1-mediated Autophagy

Abstract: Proteotoxic stress is a major stimulus and risk factor for the neuropathogenesis in central nervous system (CNS), which is tightly associated with neurodegenerative diseases. Here, we identify acrylamide (ACR), a type-2 alkene that is commonly detected in deep-fried starch food and used in water industry and biomedical laboratories, as a potent and universal inducer of proteotoxic stress in mouse brain, as well as in cultured mouse neural stem cells, neurons and astrocytes, three major cell types in CNS. Aggre… Show more

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