Acteoside as the Analgesic Principle of Cedron (Lippia hriphylla), a Peruvian Medicinal Plant.

Nakamura, Tomonori; Okuyama, Emi; Tsukada, Atsushi; Yamazaki, Mikio; Satake, Motoyoshi; Nishibe, Sansei; Deyama, Takeshi; Moriya, Akira; Maruno, Masao; Nishimura, Hiroaki

doi:10.1248/cpb.45.499

Cited by 72 publications

(34 citation statements)

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“…Compound 1 was identified as acteoside by comparison of the NMR data with those reported. 5) Compound 2 depicted the similar NMR spectra to those of 1 only different in the chemical shifts of C 4 -H (ca.…”

Section: Methodsmentioning

confidence: 87%

“…Acteoside and the related compounds are known to be widely distributed in the plants belonging to Scrophulariaceae, Verbenaceae, Oleaceae and Labiatae, and compounds of this type have been shown to have a variety of biological activities; anti-tumor, 6) hepatoprotective, 7) anti-oxidant, 8) anti-inflamatory, 9) anti-nephritic, 10) and analgesic 5) activities. Saracoglu et al 6) isolated acteoside and some related compounds from Turkish medicinal plants Phlomis armeniaca and Scutellaria salviifolia, and checked their cytotoxic and cytostatic activities against some tumor cells.…”

Section: Resultsmentioning

confidence: 99%

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Antiproliferative Constituents in the Plants 7. Leaves of Clerodendron bungei and Leaves and Bark of C. trichotomum.

Nagao

Abe

Okabe

2001

Biological & Pharmaceutical Bulletin

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The constituents of the leaves of Clerodendron bungei STEUD. (Verbenaceae) and leaves and bark of C. trichotomum THUNB. were investigated guided by the antiproliferative activity against three tumor cell lines (MK-1: human gastric adenocarcinoma, HeLa: human uterus carcinoma, and B16F10: murine melanoma). Two phenylethanoid glycoside caffeic acid esters, acteoside and isoacteoside, were isolated as the constituents which selectively inhibit the growth of B16F10 cells.The antiproliferative activities against B16F10 cells of acteoside (GI 50 : 8 m mM), isoacteoside (8 m mM) and their methanolysis products, methyl caffeate (26 m mM), 3,4-dihydroxyphenethyl alcohol (8 m mM), 3,4-dihydroxyphenethyl glucoside (10 m mM), desrhamnosyl acteoside (6 m mM), and desrhamnosyl isoacteoside (6 m mM) suggested that the 3,4-dihydroxyphenethyl alcohol group might be more responsible for the activities of acteoside and isoacteoside than the caffeoyl group. The activities of chlorogenic acid, 3,4-dihydroxyphenylacetic acid, 3-(3,4-dihydroxyphenyl) alanine, 3,4-dihydroxy-phenethylamine hydrochloride, ferulic acid, sinapic acid, and five dihydroxybenzoic acids were also determined and compared with those of the above compounds.

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Section: Methodsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Antiproliferative Constituents in the Plants 7. Leaves of Clerodendron bungei and Leaves and Bark of C. trichotomum.

Nagao

Abe

Okabe

2001

Biological & Pharmaceutical Bulletin

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“…Acteoside has also been found to have analgesic activities in a number of studies [203,204]. For example, Nakamura et al reported that acteoside exerts analgesic effect on acetic acid-induced writhing and tail pressure pain in mouse models at oral dosages of 300 mg/kg and 100 mg/kg, respectively [204].…”

Section: Hepatoprotective and Analgesic Effectsmentioning

confidence: 99%

“…For example, Nakamura et al reported that acteoside exerts analgesic effect on acetic acid-induced writhing and tail pressure pain in mouse models at oral dosages of 300 mg/kg and 100 mg/kg, respectively [204]. SAR studies showed that the lack of hydroxyl groups in the aglycone or the removal of caffeoyl and phenethyl moieties (e.g., cistanoids F and decaffeoyl acteoside) will attenuate the analgesic activity.…”

Section: Hepatoprotective and Analgesic Effectsmentioning

confidence: 99%

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Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics

Fu¹,

Pang²,

Wong

2008

CMC

136

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ABATRACTNatural products have long been regarded as excellent sources for drug discovery given their structure diversity and wide variety of biological activities. Phenylethanoid glycosides are naturally occurring compounds of plant origin and are structurally characterized with a hydroxyphenylethyl moiety to which a glucopyranose is linked through a glycosidic bond. To date several hundred compounds of this type have been isolated from medicinal plants and further pharmacological studies in vitro or in vivo have shown that these compounds possess a broad array of biological activities including antibacterial, antitumor, antiviral, anti-inflammatory, neuro-protective, antioxidant, hepatoprotective, immunomodulatory, and tyrosinase inhibitory actions. Given their extensive activity profile, structure-activity relationships analyses of these compounds have been performed in a number of studies to reveal potential leads for future drug design. This article will summarize the major developments in phenylethanoid glycosides-based research in the past decade. The progresses made in phytochemistry and biological activity studies of these compounds will be reviewed. Particular attention will be given to the novel structures identified to date and the prominent therapeutic values associated with these molecules.

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Synthesis of Conandroside: A Dihydroxyphenylethyl Glycoside fromConandron ramaidioides

et al. 2000

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Acteoside as the Analgesic Principle of Cedron (Lippia hriphylla), a Peruvian Medicinal Plant.

Cited by 72 publications

References 0 publications

Antiproliferative Constituents in the Plants 7. Leaves of Clerodendron bungei and Leaves and Bark of C. trichotomum.

Antiproliferative Constituents in the Plants 7. Leaves of Clerodendron bungei and Leaves and Bark of C. trichotomum.

Naturally Occurring Phenylethanoid Glycosides: Potential Leads for New Therapeutics

Synthesis of Conandroside: A Dihydroxyphenylethyl Glycoside fromConandron ramaidioides

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