ACTH has beneficial effects on stuttering in ADHD and ASD patients with ESES: A retrospective study

Altunel, Attila; Sever, Ali; Altunel, Emine Özlem

doi:10.1016/j.braindev.2016.09.001

Cited by 9 publications

(3 citation statements)

References 29 publications

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“…In 2002, Chen and colleagues observed that selective COX2 inhibitors decreased membrane excitability and decreased back propagation action potential induced Ca2+ influx, a key feature of LTP. Taken together, normalization of these genes' expression by ACTH may underlie better control of calcium homeostasis and hyperexcitability that is required for normal neural network function and subsequently preventing cognitive dysfunction; as such, this may be part of the molecular mechanisms for improved outcome seen with ACTH treatment (Sher and Sheikh, 1993;Hernan et al, 2014;Altunel et al, 2017bAltunel et al, , 2017a.…”

Section: Discussionmentioning

confidence: 99%

Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures

Brabec

Ouardouz²,

Mahoney

et al. 2022

Preprint

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Early-life seizures (ELS) are associated with persistent cognitive deficits such as ADHD and memory impairment. These co-morbidities have a dramatic negative impact on the quality of life of patients. Therapies that improve cognitive outcomes have enormous potential to improve patients’ quality of life. Our previous work in a rat flurothyl-induction model showed that administration of adrenocorticotropic hormone (ACTH) at time of seizure induction led to improved learning and memory in the animals despite no effect on seizure latency or duration. Administration of dexamethasone (Dex), a corticosteroid, did not have the same positive effect on learning and memory and has even been shown to exacerbate injury in a rat model of temporal lobe epilepsy. We hypothesized that ACTH exerted positive effects on cognitive outcomes through beneficial changes to gene expression and proposed that administration of ACTH at seizure induction would return gene-expression in the brain towards the normal pattern of expression in the Control animals whereas Dex would not. Twenty-six Sprague-Dawley rats were randomized into vehicle- Control, and ACTH-, Dex-, and vehicle-ELS. Rat pups were subjected to 60 flurothyl seizures from P5 to P15. After seizure induction, brains were removed and the hippocampus and PFC were dissected, RNA was extracted and sequenced, and differential expression analysis was performed using generalized estimating equations. Differential expression analysis showed that ACTH pushes gene expression in the brain back to a more normal state of expression through enrichment of pathways involved in supporting homeostatic balance and down-regulating pathways that might contribute to excitotoxic cell-damage post-ELS.

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Section: Discussionmentioning

confidence: 99%

Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures

Brabec

Ouardouz²,

Mahoney

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…По имеющимся данным, симптомы СДВГ (особенно нарушение внимания, но также и гиперактивность-импульсивность) могут также быть следствием субклинических эпилептиформных разрядов на ЭЭГ в рамках когнитивной эпилептиформной дезинтеграции при отсутствии клинических проявлений эпилептических приступов [22,56]. В том числе описана клиническая картина СДВГ при электрическом эпилептическом статусе сна [18]. В исследовании A. Altunel и соавт.…”

Section: Ch I Ld Neurology R U S S I a N J O U R N A L O Funclassified

“…У 12 из 25 пациентов заикание полностью прекратилось. Линейный регрессионный анализ установил, что уменьшение индекса эпилептиформной активности на фоне гормональной терапии было достоверным прогностическим фактором улучшения симптомов СДВГ, аутистикоподобного расстройства и заикания [18].…”

Section: Ch I Ld Neurology R U S S I a N J O U R N A L O Funclassified

Attention deficit hyperactivity disorder: concomitant diseases with an emphasis on epilepsy

Пылаева¹,

Шатенштейн

Мukhin³

2018

Rus. ž. det. nevrol.

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Attention deficit hyperactivity disorder (ADHD) is the most common cause of behavioral disorders and learning difficulties in preschool and school-age children. Patients with ADHD are often diagnosed with concomitant diseases, which creates additional diagnostic and therapeutic challenges and leads to a more significant reduction in the quality of life. ADHD is often associated with epilepsy: ADHD manifestations are more common in individuals with epilepsy, and vice versa, patients with ADHD are more likely to have epilepsy. The estimated prevalence of ADHD in children is 7–9 %, whereas in children with epilepsy, it reaches 20–50 %. Epilepsy is also one of the most common diseases in children (affecting approximately 1 % of the pediatric population), which is often aggravated by concomitant diseases, including cognitive, behavioral and emotional disorders. Various factors, such as characteristics of epileptic process and lesions in particular portions of the brain, can underlie the development of ADHD in epilepsy. Epileptiform activity and adverse effects of antiepileptic drugs can also play an important etiological role. Some antiepileptic drugs (such as barbiturates) may cause symptoms similar to those in ADHD (in this case, inattentiveness and hyperactivity shall be considered as adverse events that can be reduced or eliminated after cessation of the drug) or exacerbate ADHD symptoms in patients with these disorders. Therefore, the drugs with no negative impact on concomitant diseases or with a positive therapeutic effect for both diseases are preferable in these cases.High prevalence of the ADHD/epilepsy combination leads to a greater reduction in the quality of life, suggesting high relevance of this problem and requiring a revision of therapeutic approaches.

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Sex Differences in Childhood Stuttering and Coexisting Developmental Disorders

Briley

Merlo²,

Ellis

2021

J Dev Phys Disabil

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ACTH has beneficial effects on stuttering in ADHD and ASD patients with ESES: A retrospective study

Cited by 9 publications

References 29 publications

Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures

Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures

Attention deficit hyperactivity disorder: concomitant diseases with an emphasis on epilepsy

Sex Differences in Childhood Stuttering and Coexisting Developmental Disorders

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