Actinomyces in Pregnancy: A Review of the Literature

Estrada, Sarah M.; Magann, Everett F.; Napolitano, Peter G.

doi:10.1097/ogx.0000000000000423

Cited by 13 publications

(4 citation statements)

References 21 publications

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“…The metabolic ability of Actinomyces may be due to the decomposition and recovery of organic compounds in the human gastrointestinal system [ 50 ]. In rare conditions, chorioamnionitis and preterm delivery can be complicated by Actinomyces infection [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

A Higher Abundance of Actinomyces spp. in the Gut Is Associated with Spontaneous Preterm Birth

Tsai

Chan

et al. 2023

Microorganisms

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Preterm birth is a major challenge in pregnancy worldwide. Prematurity is the leading cause of death in infants and may result in severe complications. Nearly half of preterm births are spontaneous, but do not have recognizable causes. This study investigated whether the maternal gut microbiome and associated functional pathways might play a key role in spontaneous preterm birth (sPTB). Two hundred eleven women carrying singleton pregnancies were enrolled in this mother-child cohort study. Fecal samples were freshly collected at 24–28 weeks of gestation before delivery, and the 16S ribosomal RNA gene was sequenced. Microbial diversity and composition, core microbiome, and associated functional pathways were then statistically analyzed. Demographic characteristics were collected using records from the Medical Birth Registry and questionnaires. The result showed that the gut microbiome of mothers with over-weight (BMI ≥ 24) before pregnancy have lower alpha diversity than those with normal BMI before pregnancy. A higher abundance of Actinomyces spp. was filtered out from the Linear discriminant analysis (LDA) effect size (LEfSe), Spearman correlation, and random forest model, and was inversely correlated with gestational age in sPTB. The multivariate regression model showed that the odds ratio of premature delivery was 3.274 [95% confidence interval (CI): 1.349; p = 0.010] in the group with over-weight before pregnancy with a cutoff Hit% > 0.022 for Actinomyces spp. The enrichment of Actinomyces spp. was negatively correlated with glycan biosynthesis and metabolism in sPTB by prediction from the Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) platform. Maternal gut microbiota showing a lower alpha diversity, increased abundance of Actinomyces spp., and dysregulated glycan metabolism may be associated with sPTB risk.

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Section: Discussionmentioning

confidence: 99%

A Higher Abundance of Actinomyces spp. in the Gut Is Associated with Spontaneous Preterm Birth

Tsai

Chan

et al. 2023

Microorganisms

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“…A. meyeri has also been found to be an uncommon source of obstetrical infection [ 8 ]. These cases are described in a recent literature review published in 2017, which found 17 cases of obstetric related Actinomyces infections.…”

Section: Discussionmentioning

confidence: 99%

“…These cases are described in a recent literature review published in 2017, which found 17 cases of obstetric related Actinomyces infections. A particular species of Actinomyces was identified in only five of these cases, with the identified species including A. israelii , A. neuii , and A. meyeri [ 8 ]. Additionally, a single report describes a case of fatal sepsis related to pyomyoma; however, this infection was not following any surgical intervention or instrumentation of the uterus.…”

Section: Discussionmentioning

confidence: 99%

Actinomyces meyeri: A Rare Cause of Postsurgical Pelvic Actinomycosis

Markey

Vestal

2018

Case Reports in Obstetrics and Gynecology

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“…It can result in infection after a break in the normal defenses of the mucosa [128]. Actinomycosis is found in pregnancy very rarely, but according to a recent review, if it occurs, it is mainly associated with preterm deliveries [129].…”

Section: Actinomycesmentioning

confidence: 99%

Maternal Infection and Preterm Birth: From Molecular Basis to Clinical Implications

et al. 2023

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As the leading cause of neonatal morbidity and mortality, preterm birth is recognized as a major public health concern around the world. The purpose of this review is to analyze the connection between infections and premature birth. Spontaneous preterm birth is commonly associated with intrauterine infection/inflammation. The overproduction of prostaglandins caused by the inflammation associated with an infection could lead to uterine contractions, contributing to preterm delivery. Many pathogens, particularly Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Gardnerella vaginalis, Ureaplasma urealyticum, Mycoplasma hominis, Actinomyces, Candida spp., and Streptococcus spp. have been related with premature delivery, chorioamnionitis, and sepsis of the neonate. Further research regarding the prevention of preterm delivery is required in order to develop effective preventive methods with the aim of reducing neonatal morbidity.

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Actinomyces in Pregnancy: A Review of the Literature

Cited by 13 publications

References 21 publications

A Higher Abundance of Actinomyces spp. in the Gut Is Associated with Spontaneous Preterm Birth

A Higher Abundance of Actinomyces spp. in the Gut Is Associated with Spontaneous Preterm Birth

Actinomyces meyeri: A Rare Cause of Postsurgical Pelvic Actinomycosis

Maternal Infection and Preterm Birth: From Molecular Basis to Clinical Implications

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