Action potential subpopulations within human muscle sympathetic nerve activity: Discharge properties and governing mechanisms

Klassen, Stephen A.; Shoemaker, J. Kevin

doi:10.1016/j.autneu.2020.102743

Cited by 11 publications

(4 citation statements)

References 81 publications

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“…Despite unchanged MSNA burst frequency or incidence between control and ketamine trials, Huang et al (2020) did not report metrics of burst amplitude or mean burst area, which may have provided important information regarding the neural response to LBNP. As comprehensively reviewed by Klassen and Shoemaker (2021), MSNA burst frequency may remain unchanged, whereas mean burst area, amplitude and/or burst latency (i.e. conduction velocity) could be altered.…”

Section: Possible Mechanisms Affecting Cardiovascular Regulation Foll...mentioning

confidence: 99%

“…Sympathetic burst size (i.e. amplitude) is reflective of the proximity of the recording electrode to the postganglionic fibres (Klassen & Shoemaker 2021); however, changes in burst size (amplitude or area), although in the same recording site, can represent physiological differences in action potential recruitment (i.e. burst 'content').…”

Section: Possible Mechanisms Affecting Cardiovascular Regulation Foll...mentioning

confidence: 99%

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Ketamine: yay or neigh? Implications for cardiovascular regulation and considerations for field use

Berthelsen

2021

The Journal of Physiology

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Section: Possible Mechanisms Affecting Cardiovascular Regulation Foll...mentioning

confidence: 99%

Section: Possible Mechanisms Affecting Cardiovascular Regulation Foll...mentioning

confidence: 99%

Ketamine: yay or neigh? Implications for cardiovascular regulation and considerations for field use

Berthelsen

2021

The Journal of Physiology

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“…To see if subpopulations of latent neurons existed, being recruitable either spontaneously or during reflexive stimulation (Marshall et al 1961 ), and following from the preliminary work performed by Diedrich et al ( 2003 ), a wavelet-based detection method was developed to isolate and study all axons in the multi-unit sympathetic neurogram as measured with lower impedance electrodes that provided a wider recording field (Salmanpour et al 2010 ). The series of studies that emerged exposed variously sized axons (Tompkins et al 2013 ) with varying firing probabilities whereby medium sized axons provided the highest probability of firing and are under the greatest control by the baroreflex (Klassen et al 2020 ; Klassen and Shoemaker 2021 ). Under baseline conditions, the disappearance of MSNA action potentials following ganglionic blockade progresses from largest to smallest (Klassen et al 2018 ).…”

Section: Overviewmentioning

confidence: 99%

A century of exercise physiology: key concepts in neural control of the circulation

Shoemaker,

Gros

2024

Eur J Appl Physiol

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Early in the twentieth century, Walter B. Cannon (1871–1945) introduced his overarching hypothesis of “homeostasis” (Cannon 1932)—the ability to sustain physiological values within a narrow range necessary for life during periods of stress. Physical exercise represents a stress in which motor, respiratory and cardiovascular systems must be integrated across a range of metabolic stress to match oxygen delivery to oxygen need at the cellular level, together with appropriate thermoregulatory control, blood pressure adjustments and energy provision. Of these, blood pressure regulation is a complex but controlled variable, being the function of cardiac output and vascular resistance (or conductance). Key in understanding blood pressure control during exercise is the coordinating role of the autonomic nervous system. A long history outlines the development of these concepts and how they are integrated within the exercise context. This review focuses on the renaissance observations and thinking generated in the first three decades of the twentieth century that opened the doorway to new concepts of inquiry in cardiovascular regulation during exercise. The concepts addressed here include the following: (1) exercise and blood pressure, (2) central command, (3) neurovascular transduction with emphasis on the sympathetic nerve activity and the vascular end organ response, and (4) tonic neurovascular integration.

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“…Recent work from Shoemaker and colleagues has allowed the study of post-ganglionic sympathetic nerve firing in humans. This is methodologically possible by recording sympathetic nerve activity at higher sampling frequencies (10,000 Hz) and using post-processing software to separate a burst of sympathetic activity into individual action potentials [32,33]. Under baseline conditions, older adults demonstrate more action potentials per burst of sympathetic activity than young adults [34].…”

Section: Changes With Agingmentioning

confidence: 99%

Sex Differences in Neurovascular Control: Implications for Obstructive Sleep Apnea

Bock,

Greenlund,

Somers

et al. 2023

IJMS

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Patients with obstructive sleep apnea (OSA) have a heightened risk of developing cardiovascular diseases, namely hypertension. While seminal evidence indicates a causal role for sympathetic nerve activity in the hypertensive phenotype commonly observed in patients with OSA, no studies have investigated potential sex differences in the sympathetic regulation of blood pressure in this population. Supporting this exploration are large-scale observational data, as well as controlled interventional studies in healthy adults, indicating that sleep disruption increases blood pressure to a greater extent in females relative to males. Furthermore, females with severe OSA demonstrate a more pronounced hypoxic burden (i.e., disease severity) during rapid eye movement sleep when sympathetic nerve activity is greatest. These findings would suggest that females are at greater risk for the hemodynamic consequences of OSA and related sleep disruption. Accordingly, the purpose of this review is three-fold: (1) to review the literature linking sympathetic nerve activity to hypertension in OSA, (2) to highlight recent experimental data supporting the hypothesis of sex differences in the regulation of sympathetic nerve activity in OSA, and (3) to discuss the potential sex differences in peripheral adrenergic signaling that may contribute to, or offset, cardiovascular risk in patients with OSA.

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Action potential subpopulations within human muscle sympathetic nerve activity: Discharge properties and governing mechanisms

Cited by 11 publications

References 81 publications

Ketamine: yay or neigh? Implications for cardiovascular regulation and considerations for field use

Ketamine: yay or neigh? Implications for cardiovascular regulation and considerations for field use

A century of exercise physiology: key concepts in neural control of the circulation

Sex Differences in Neurovascular Control: Implications for Obstructive Sleep Apnea

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