Activated steady status and distinctive FcεRI-mediated responsiveness in basophils of atopic dermatitis

Imamura, Shinya; Washio, Ken; Mizuno, Mayuko; Oda, Yoshiko; Fukunaga, Atsushi; Nishigori, Chikako

doi:10.1016/j.alit.2021.01.005

Cited by 10 publications

(5 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The significantly higher expression of CD203c and CD63 on basophils at steady state in CIndU patients compared to HCs may also be influenced to the higher proportion of CholU complicated by AD. Indeed, we previously reported higher CD203c and CD63 expression on basophils at steady state in AD patients (17). Therefore, a population that does not differ statistically should be analyzed.…”

Section: Discussionmentioning

confidence: 99%

IgE receptor responsiveness of basophils in chronic inducible urticaria

et al. 2022

Self Cite

View full text Add to dashboard Cite

IntroductionChronic inducible urticaria (CIndU) is a subgroup of chronic urticaria induced by a specific stimulus. We evaluated basophil characteristics in patients with CIndU and compared with those in patients with chronic spontaneous urticaria (CSU) and healthy controls (HCs).MethodsBlood was collected from patients, and a basophil activation test (BAT) was performed. Basophil responsiveness and surface marker expression in patients with CIndU were compared with those in patients with CSU and HCs. For some patients with CIndU, blood was collected before and after wheals were induced. In these cases, we compared the responsiveness of basophils before and after the appearance of wheals.ResultHCs (n=23) and patients with CIndU (n=24) or CSU (n=38) were enrolled in the study. The degree of basophil activation at steady state in patients with CIndU was higher than in HCs. Basophil responsiveness via high-affinity IgE receptor (FcϵRI) stimulation with anti-IgE or anti-FcϵRI antibody in patients with CIndU was equivalent to that in HCs, and higher than that in patients with CSU. No abnormalities in IgE and FcϵRI expressions on the surface of basophils in patients with CIndU were observed. When we induced wheals in some patients with CIndU and performed a BAT before and after the appearance of wheals, no significant changes were found.ConclusionPeripheral blood basophils in CIndU were slightly activated at steady state, but no abnormalities in basophil responsiveness. In future, a higher number of cases should be enrolled to confirm the role of basophils and refine therapeutic targets for CIndU.

show abstract

Section: Discussionmentioning

confidence: 99%

IgE receptor responsiveness of basophils in chronic inducible urticaria

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Besides being involved in acute and hyper-acute reactions, basophils also sustain persisting local and systemic inflammation, especially in the skin [40] , [41] , [42] , [43] , [44] . Basophils also constitute the main granulocytic white cell subpopulation in delayed hypersensitivity reaction infiltrates [45] and may provide support to Th2 responses through IL4/IL13 release [46] .…”

Section: Discussionmentioning

confidence: 99%

Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients

Pignatti

Ramirez

Russo

et al. 2023

Vaccine

View full text Add to dashboard Cite

“…Second, the basophil function may have been impaired in the IgE receptor–mediated reaction at E1. It has been reported that severe dermatitis reduces the reactivity of basophils to IgE stimulation in patients with AD ( 20 ). In this study, AD lesions became well controlled between E1 and E2 in 9 patients, and the other 5 patients were maintained at a low disease activity (IGA ≤2) over the period.…”

Section: Discussionmentioning

confidence: 99%

Immunological Changes of Basophil Hyperreactivity to Sweat in Patients With Well-Controlled Atopic Dermatitis

et al. 2022

View full text Add to dashboard Cite

BackgroundSweat aggravates atopic dermatitis (AD). In patients with AD, type-I hypersensitivity to sweat may be shown by histamine release from patients’ basophils in response to the semi-purified sweat antigen (QR), and the presence of specific immunoglobulin E (IgE) binding to MGL_1304, the component of QR. However, there has been no information on the immunological changes of type-I hypersensitivity to the sweat antigen in patients with well-controlled AD using topical corticosteroids (TCSs) and/or biologics as treatments.MethodHistamine-releasing tests using patients’ basophils and QR and the detection of serum IgE against MGL_1304 and mite allergen Der f 1 were performed in patients with AD who were well controlled by topical TCS with/without dupilumab for 53–96 weeks.ResultsIn total, 14 patients were enrolled. Seven patients received TCS therapy alone (TCS group), and seven patients received TCS with dupilumab therapy (dupilumab group). In all participants, the level of specific IgE against MGL_1304 decreased after treatments, but histamine release from basophils in response to QR did not show a statistically significant reduction; rather, it increased. In the dupilumab group, all changes in histamine release induced by QR (increase), the IgE level against MGL_1304 (decrease), and that against Der f 1 (decrease) were statistically significant, whereas the TCS group showed no significant change in any of them.ConclusionThe well-controlled condition for 53–96 weeks resulted in no reduction of the hyperreactivity of basophils against in patients with AD, even with the treatment with dupilumab. This study suggests persistent basophil hyperreactivity to sweat antigen over a year or longer.

show abstract

Activated steady status and distinctive FcεRI-mediated responsiveness in basophils of atopic dermatitis

Cited by 10 publications

References 38 publications

IgE receptor responsiveness of basophils in chronic inducible urticaria

IgE receptor responsiveness of basophils in chronic inducible urticaria

Hypersensitivity reactions to anti-SARS-CoV-2 vaccines: Basophil reactivity to excipients

Immunological Changes of Basophil Hyperreactivity to Sweat in Patients With Well-Controlled Atopic Dermatitis

Contact Info

Product

Resources

About