Activating proper inflammation for wound-healing acceleration via mesoporous silica nanoparticle tissue adhesive

Pan, Zhao; Zhang, Kai-Run; Gao, Huai‐Ling; Zhou, Yong; Yan, Beibei; Chen, Yang; Zhang, Zhiyuan; Dong, Liang; Chen, Siming; Xu, Rui; Zou, Duohong

doi:10.1007/s12274-020-2619-x

Cited by 37 publications

(20 citation statements)

References 23 publications

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“…Over the last two decades, the research attention on DDSs based on inorganic materials like mesoporous silica particles, gold nanoparticles, and graphene oxide [ 5 ] has seen rapid growth in the field of biomedicine, expanding in many directions. These materials were employed as carriers of anti-inflammatory agents [ 6 , 7 , 8 ], tumor diagnostic probes [ 9 , 10 ], as well as in biomedical imaging [ 11 , 12 ] and tissue engineering [ 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

PEG-Coated Large Mesoporous Silicas as Smart Platform for Protein Delivery and Their Use in a Collagen-Based Formulation for 3D Printing

Niclot

Montalbano

Fiorilli

et al. 2021

IJMS

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Silica-based mesoporous systems have gained great interest in drug delivery applications due to their excellent biocompatibility and high loading capability. However, these materials face challenges in terms of pore-size limitations since they are characterized by nanopores ranging between 6–8 nm and thus unsuitable to host large molecular weight molecules such as proteins, enzymes and growth factors (GFs). In this work, for an application in the field of bone regeneration, large-pore mesoporous silicas (LPMSs) were developed to vehicle large biomolecules and release them under a pH stimulus. Considering bone remodeling, the proposed pH-triggered mechanism aims to mimic the release of GFs encased in the bone matrix due to bone resorption by osteoclasts (OCs) and the associated pH drop. To this aim, LPMSs were prepared by using 1,3,5-trimethyl benzene (TMB) as a swelling agent and the synthesis solution was hydrothermally treated and the influence of different process temperatures and durations on the resulting mesostructure was investigated. The synthesized particles exhibited a cage-like mesoporous structure with accessible pores of diameter up to 23 nm. LPMSs produced at 140 °C for 24 h showed the best compromise in terms of specific surface area, pores size and shape and hence, were selected for further experiments. Horseradish peroxidase (HRP) was used as model protein to evaluate the ability of the LPMSs to adsorb and release large biomolecules. After HRP-loading, LPMSs were coated with a pH-responsive polymer, poly(ethylene glycol) (PEG), allowing the release of the incorporated biomolecules in response to a pH decrease, in an attempt to mimic GFs release in bone under the acidic pH generated by the resorption activity of OCs. The reported results proved that PEG-coated carriers released HRP more quickly in an acidic environment, due to the protonation of PEG at low pH that catalyzes polymer hydrolysis reaction. Our findings indicate that LPMSs could be used as carriers to deliver large biomolecules and prove the effectiveness of PEG as pH-responsive coating. Finally, as proof of concept, a collagen-based suspension was obtained by incorporating PEG-coated LPMS carriers into a type I collagen matrix with the aim of designing a hybrid formulation for 3D-printing of bone scaffolds.

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Section: Introductionmentioning

confidence: 99%

PEG-Coated Large Mesoporous Silicas as Smart Platform for Protein Delivery and Their Use in a Collagen-Based Formulation for 3D Printing

Niclot

Montalbano

Fiorilli

et al. 2021

IJMS

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“…After rapid clearance of MSNs, the inflammatory response gradually subsided and the wound edges integrated without persistent inflammation. 201 Macrophages play key roles in each phase of wound healing, i.e., inflammation, proliferation, and remodeling phases. Initially and during the inflammation phase, macrophages are pro-inflammatory (M1-like phenotypes); however, as wounds heal, the local macrophage population becomes anti-inflammatory (M2-like phenotypes).…”

Section: Chronic Inflammationmentioning

confidence: 99%

“…The mild inflammation mounted against the MSNs induced tissue regeneration through replacing MSNs with fibroblasts and created a new extracellular matrix mainly composed of collagen, elastin, and fibronectin (Figure ). After rapid clearance of MSNs, the inflammatory response gradually subsided and the wound edges integrated without persistent inflammation …”

Section: Nanomedicine Strategies To Address Chronic Inflammationmentioning

confidence: 99%

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Nanomedicine in Healing Chronic Wounds: Opportunities and Challenges

et al. 2020

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The poor healing associated with chronic wounds affects millions of people worldwide through high mortality rates and associated costs. Chronic wounds present three main problems: First, the absence of a suitable environment to facilitate cell migration, proliferation, and angiogenesis; second, bacterial infection; and third, unbalanced and prolonged inflammation. Unfortunately, current therapeutic approaches have not been able to overcome these main issues and, therefore, have limited clinical success. Over the past decade, incorporating the unique advantages of nanomedicine into wound healing approaches has yielded promising outcomes. Nanomedicine is capable of stimulating various cellular and molecular mechanisms involved in the wound microenvironment via antibacterial, anti-inflammatory, and angiogenetic effects, potentially reversing the wound microenvironment from nonhealing to healing. This review briefly discusses wound healing mechanisms and pathophysiology and then highlights recent findings regarding the opportunities and challenges of using nanomedicine in chronic wound management.

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“…This phenomenon originates from the low success rate of adhesives in chronic wounds [ 118 , 119 ]; for instance, glutaraldehyde cross-linked albumin adhesives could not be widely applied for pyogenic or granulomatous inflammation [ 120 , 121 ]. In this regard, inorganic nanomaterials exhibiting anti-inflammatory activity offer great opportunities in managing chronic skin wounds [ 122 ]. Loading anti-inflammatory drugs or other bioactive molecules into MSNs is likely beneficial for reducing inflammation responses and producing the next generation of adhesives.…”

Section: Multiple Roles Of Msns In Skin Wound Healingmentioning

confidence: 99%

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

et al. 2021

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Exploring new therapies for managing skin wounds is under progress and, in this regard, mesoporous silica nanoparticles (MSNs) and mesoporous bioactive glasses (MBGs) offer great opportunities in treating acute, chronic, and malignant wounds. In general, therapeutic effectiveness of both MSNs and MBGs in different formulations (fine powder, fibers, composites etc.) has been proved over all the four stages of normal wound healing including hemostasis, inflammation, proliferation, and remodeling. The main merits of these porous substances can be summarized as their excellent biocompatibility and the ability of loading and delivering a wide range of both hydrophobic and hydrophilic bioactive molecules and chemicals. In addition, doping with inorganic elements (e.g., Cu, Ga, and Ta) into MSNs and MBGs structure is a feasible and practical approach to prepare customized materials for improved skin regeneration. Nowadays, MSNs and MBGs could be utilized in the concept of targeted therapy of skin malignancies (e.g., melanoma) by grafting of specific ligands. Since potential effects of various parameters including the chemical composition, particle size/morphology, textural properties, and surface chemistry should be comprehensively determined via cellular in vitro and in vivo assays, it seems still too early to draw a conclusion on ultimate efficacy of MSNs and MBGs in skin regeneration. In this regard, there are some concerns over the final fate of MSNs and MBGs in the wound site plus optimal dosages for achieving the best outcomes that deserve careful investigation in the future.

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Activating proper inflammation for wound-healing acceleration via mesoporous silica nanoparticle tissue adhesive

Cited by 37 publications

References 23 publications

PEG-Coated Large Mesoporous Silicas as Smart Platform for Protein Delivery and Their Use in a Collagen-Based Formulation for 3D Printing

PEG-Coated Large Mesoporous Silicas as Smart Platform for Protein Delivery and Their Use in a Collagen-Based Formulation for 3D Printing

Nanomedicine in Healing Chronic Wounds: Opportunities and Challenges

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

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