Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress

Salgado, Maria Cristina de Oliveira; Metón, Isidoro; Anemaet, Ida G.; Baanante, Isabel V.

doi:10.1016/j.bbagrm.2014.01.005

Cited by 17 publications

(11 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus far, the mechanism behind the increased production and secretion of ALT in Ppara -/- neonatal liver still remains unclear. It is notable that ALT2 expression is up-regulated under metabolic stress and that plasma and tissue ALT levels are elevated in response to endoplasmic reticulum (ER) stress ( Salgado et al, 2014 ; Josekutty et al, 2013 ). Interestingly, defective PPARα signaling has been reported to cause hepatic mitochondrial and ER stress in the pathogenesis of hepatic steatosis through reduced mRNA expression of the sarco/endoplasmic reticulum calcium ATPase (SERCA) ( Su et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

Rando

Tan

Khaled

et al. 2016

eLife

View full text Add to dashboard Cite

In mammals, hepatic lipid catabolism is essential for the newborns to efficiently use milk fat as an energy source. However, it is unclear how this critical trait is acquired and regulated. We demonstrate that under the control of PPARα, the genes required for lipid catabolism are transcribed before birth so that the neonatal liver has a prompt capacity to extract energy from milk upon suckling. The mechanism involves a fetal glucocorticoid receptor (GR)-PPARα axis in which GR directly regulates the transcriptional activation of PPARα by binding to its promoter. Certain PPARα target genes such as Fgf21 remain repressed in the fetal liver and become PPARα responsive after birth following an epigenetic switch triggered by β-hydroxybutyrate-mediated inhibition of HDAC3. This study identifies an endocrine developmental axis in which fetal GR primes the activity of PPARα in anticipation of the sudden shifts in postnatal nutrient source and metabolic demands.DOI: http://dx.doi.org/10.7554/eLife.11853.001

show abstract

Section: Discussionmentioning

confidence: 99%

Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

Rando

Tan

Khaled

et al. 2016

eLife

View full text Add to dashboard Cite

show abstract

“…In humans, elevated serum ALT levels are correlated with hepatic injury conditions, non-alcoholic fatty liver disease and other pathologies such as obesity and metabolic syndrome (Kim, Flamm, Bisceglie & Bodenheimer, 2008;Kunutsor & Seddoh, 2014;Limami et al, 2008). In addition, ALT is a stress responsive gene, the expression of which increases under various stressful conditions, including high temperature, hyperosmotic stress, hypoxia stress and endoplasmic reticulum stress (Cronkite, Diekman, Lewallen & Phillips, 1993;Diab & Limami, 2016;Faisal, Fattah, Hommosany, Ali & Gawad, 2008;Salgado, Met on, Anemaet & Baanante, 2014).…”

Section: Enzymes Involved In Amino Acids Metabolismmentioning

confidence: 99%

“…In addition, glutamate acts as precursors for the synthesis of glucose by gluconeogenesis (Newsholme, Lima, Procopio, Pithoncuri, Doi, Bazotte & Curi, 2003). Moreover, glutamate could be used for neurotransmitter synthesis and glutathione (GSH) production in cell stressful conditions, which protect cells from damage of redox crisis (Newsholme, Lima, Procopio & Pithoncuri, 2003;Salgado et al, 2014). The increasing glutamate synthesis is often involved in adaptive strategy for organisms to stress factors.…”

Section: Enzymes Involved In Amino Acids Metabolismmentioning

confidence: 99%

Carbohydrate and amino acids metabolic response to heat stress in the intestine of the sea cucumberApostichopus japonicus

Zhou

Yang

2017

Aquac Res

View full text Add to dashboard Cite

The sea cucumber Apostichopus japonicus is an economic species mainly distributed along the coast of northern China, south‐eastern Russia, Japan, Republic of Korea and Democratic People's Republic of Korea. Aquaculture industry of A. japonicus has been facing severe challenge of high temperature. In this study, we studied the mRNA expression profiles of eight key metabolic enzymes involved in carbohydrate and amino acids metabolism in A. japonicus under heat stress. The expression of hexokinase, pyruvate kinase and malate dehydrogenase showed downregulated response to heat stress, while the expression of glutamate dehydrogenase, alanine transaminase and branched‐chain aminotransferase showed upregulated response. In addition, the expression of lactate dehydrogenase and glutamate synthase showed no significant difference. We also applied 1H NMR‐based metabolomics to investigate metabolic changes in the intestine tissue of A. japonicus under heat stress, the results of which revealed nine increased and 10 decreased metabolites in the heat stress group. These response genes and metabolites have potential to become markers for identifying severity of heat stress. More importantly, our findings suggest significant links between gene expression and metabolites changing, highlighting regulation networks of carbohydrate and amino acid metabolism in heat‐stressed A. japonicus.

show abstract

“…Several genes related to virus replication were found to be of interest, including engrailed nuclear homeoprotein-regulated protein [64], 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ASGPA) [65,66], alanine aminotransferase 2 (ALT2) [67,68], U2AF domain protein (U2AF) [69,70], adenylate cyclase type 5 (ACT5) [71], EF-hand domain-containing protein (EFHP) [72,73], prostatic acid phosphatase (PAP) [74], and zinc ribbon domain protein (ZRDP) [75]. In this study, the expression level of these genes were all down-regulated in the transcriptome of BC9 following BmNPV infection ( Fig 5).…”

Section: Multiple Genes Have Potential Roles In Repressing Bmnpv Infementioning

confidence: 99%

Comparative Transcriptome Analysis of Bombyx mori (Lepidoptera) Larval Midgut Response to BmNPV in Susceptible and Near-Isogenic Resistant Strains

Wang

Geng

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

Bombyx mori nucleopolyhedrovirus (BmNPV) is one of the primary pathogens causing severe economic losses in sericulture. However, the molecular mechanism of silkworm resistance to BmNPV remains largely unknown. Here, the recurrent parent P50 (susceptible strain) and the near-isogenic line BC9 (resistance strain) were used in a comparative transcriptome study examining the response to infection with BmNPV. A total of 14,300 unigenes were obtained from two different resistant strains; of these, 869 differentially expressed genes (DEGs) were identified after comparing the four transcriptomes. Many DEGs associated with protein metabolism, cytoskeleton, and apoptosis may be involved in the host response to BmNPV infection. Moreover, some immunity related genes were also altered following BmNPV infection. Specifically, after removing genetic background and individual immune stress response genes, 22 genes were found to be potentially involved in repressing BmNPV infection. These genes were related to transport, virus replication, intracellular innate immune, and apoptosis. Our study provided an overview of the molecular mechanism of silkworm resistance to BmNPV infection and laid a foundation for controlling BmNPV in the future.

show abstract

Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress

Cited by 17 publications

References 59 publications

Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

Carbohydrate and amino acids metabolic response to heat stress in the intestine of the sea cucumberApostichopus japonicus

Comparative Transcriptome Analysis of Bombyx mori (Lepidoptera) Larval Midgut Response to BmNPV in Susceptible and Near-Isogenic Resistant Strains

Contact Info

Product

Resources

About