Activating transcription factor 5 (ATF5) is essential for the maturation and survival of mouse basal vomeronasal sensory neurons

Nakano, Hitoo; Iida, Yoshitaka; Suzuki, Makoto; Aoki, Motohide; Umemura, Masayuki; Takahashi, Shigeru; Takahashi, Yûji

doi:10.1007/s00441-015-2283-8

Cited by 20 publications

(21 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably an incomplete ablation of basal VSNs have been also observed after loss-offunction of Ascl-1 and Ngn-1 (Cau et al, 2002), G-protein subunit Gγ-8 (Montani et al, 2013), loss-of-function of Gαo (Chamero et al, 2011), and the transcription factor ATF5 (Nakano et al, 2016). What underlies the varying responses and potential compensatory mechanisms to these mutations requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

The transcription factor Tfap2e/AP-2ε plays a pivotal role in maintaining the identity of basal vomeronasal sensory neurons

Lin

Taroc

Frías

et al. 2018

Preprint

View full text Add to dashboard Cite

Highlights• The VNO contains two major cell types that are segregated in apical and basal regions of the VNO• AP-2ε is expressed in postmitotic basal vomeronasal sensory neurons.• AP-2ε is essential to maintain the identity of basal vomeronasal sensory neurons. ABSTRACTThe identity of individual neuronal cell types is defined by the expression of specific combinations of transcriptional regulators that control cell type-specific genetic programs.The epithelium of the vomeronasal organ of mice contains two major types of vomeronasal sensory neurons (VSNs): 1) the apical VSNs which express vomeronasal 1 receptors (V1r) and the G-protein subunit Gαi2 and; 2) the basal VSNs which express vomeronasal 2 receptors (V2r) and the G-protein subunit Gαo. Both cell types originate from a common pool of progenitors and eventually acquire apical or basal identity through largely unknown mechanisms.The transcription factor AP-2ε, encoded by the Tfap2e gene, plays a role in controlling the development of GABAergic interneurons in the main and accessory olfactory bulb (AOB), moreover AP-2ε has been previously described to be expressed in the VSNs.Here we show that AP-2ε is expressed in postmitotic VSNs after they commit to the basal differentiation program. Loss of AP-2ε function resulted in reduced number of basal VSNs and in an increased number of neurons expressing markers of the apical lineage. OurAll rights reserved. No reuse allowed without permission.

show abstract

Section: Discussionmentioning

confidence: 99%

The transcription factor Tfap2e/AP-2ε plays a pivotal role in maintaining the identity of basal vomeronasal sensory neurons

Lin

Taroc

Frías

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…In rodents, normal olfactory system development and olfactory function is important for social behavior (Silverman et al, 2010; Feierstein, 2012). It is reported that ATF5 -/- mice have olfactory system impairments (Wang et al, 2012; Umemura et al, 2015; Nakano et al, 2016). In ATF5 -/- mice, the size of the OB is reduced and the laminar structure of the OB is irregular (Umemura et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…In ATF5 -/- mice, the size of the OB is reduced and the laminar structure of the OB is irregular (Umemura et al, 2015). Moreover, neuronal maturation is impaired in the MOE and VNE of ATF5 -/- mice (Wang et al, 2012; Nakano et al, 2016). ATF5 -/- male mice display reduced aggressiveness toward an intruder male mouse entering their territory.…”

Section: Discussionmentioning

confidence: 99%

“…ATF5 is widely expressed in the brain, liver, main olfactory epithelium (MOE), and vomeronasal epithelium (VNE) (Persengiev et al, 2002; Angelastro et al, 2003; Wang et al, 2012; Nakano et al, 2016). It has been reported that ATF5 regulates cell differentiation, survival, and apoptosis (Persengiev et al, 2002; Angelastro et al, 2003, 2005; Greene et al, 2009; Dluzen et al, 2011; Li et al, 2011; Liu et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Both the number and ratio of proliferation cells of the OB and SVZ was reduced in ATF5 -/- mice (Umemura et al, 2015). Furthermore, in the olfactory sensory neuron of the MOE and the vomeronasal sensory neuron of the VNE in ATF5 -/- mice, neuronal maturation was impaired and increased apoptotic cell frequency was observed (Wang et al, 2012; Nakano et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice

Umemura

Ogura

Matsuzaki

et al. 2017

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

Activating transcription factor 5 (ATF5) is a member of the CREB/ATF family of basic leucine zipper transcription factors. We previously reported that ATF5-deficient (ATF5-/-) mice demonstrated abnormal olfactory bulb development due to impaired interneuron supply. Furthermore, ATF5-/- mice were less aggressive than ATF5+/+ mice. Although ATF5 is widely expressed in the brain, and involved in the regulation of proliferation and development of neurons, the physiological role of ATF5 in the higher brain remains unknown. Our objective was to investigate the physiological role of ATF5 in the higher brain. We performed a comprehensive behavioral analysis using ATF5-/- mice and wild type littermates. ATF5-/- mice exhibited abnormal locomotor activity in the open field test. They also exhibited abnormal anxiety-like behavior in the light/dark transition test and open field test. Furthermore, ATF5-/- mice displayed reduced social interaction in the Crawley’s social interaction test and increased pain sensitivity in the hot plate test compared with wild type. Finally, behavioral flexibility was reduced in the T-maze test in ATF5-/- mice compared with wild type. In addition, we demonstrated that ATF5-/- mice display disturbances of monoamine neurotransmitter levels in several brain regions. These results indicate that ATF5 deficiency elicits abnormal behaviors and the disturbance of monoamine neurotransmitter levels in the brain. The behavioral abnormalities of ATF5-/- mice may be due to the disturbance of monoamine levels. Taken together, these findings suggest that ATF5-/- mice may be a unique animal model of some psychiatric disorders.

show abstract

Gene duplication, conservation, and divergence of activating transcription factor 5 gene in zebrafish

Zhu

Zhang

et al. 2022

J Exp Zool Pt B

View full text Add to dashboard Cite

Activating transcription factor 5 (Atf5) is a member of the ATF/CREB family of transcription factors and involved in diverse cellular functions and diseases in mammals. However, the function of atf5 remains largely unknown in fish. Here, we report the expression pattern and function of duplicated atf5 genes in zebrafish. The results showed that the gene structures of zebrafish atf5a and atf5b were similar to their mammalian orthologs. Zebrafish Atf5a and Atf5b shared an amino acid sequence identity of 40.7%. Zebrafish atf5a and atf5b had maternal origin with dynamic expression during embryonic development. Zebrafish atf5a mRNA is mainly enriched in olfactory epithelium, midbrain, and hindbrain, while zebrafish atf5b mRNA is mainly detected in midbrain, hindbrain, and liver during embryogenesis. The results of acute hypoxia experiment showed that atf5a mRNA was significantly upregulated in the brain, liver, and muscle, while atf5b mRNA was just increased significantly in the brain. Functional analysis showed that knockdown of atf5a affects the development of the ciliated neurons in zebrafish embryos. The effect was enhanced when atf5a MO was co-injected with atf5b MO. The development of ciliated neurons in zebrafish embryos was not affected by injection of atf5b MO alone. atf5a knockdown also affects the development of early-born olfactory neurons. The effects caused by atf5a knockdown could be rescued by atf5b mRNA.These results suggest that the duplicated atf5 genes may have evolved divergently and play redundant biological roles in the development of olfactory sensory neurons in zebrafish.

show abstract

Activating transcription factor 5 (ATF5) is essential for the maturation and survival of mouse basal vomeronasal sensory neurons

Cited by 20 publications

References 44 publications

The transcription factor Tfap2e/AP-2ε plays a pivotal role in maintaining the identity of basal vomeronasal sensory neurons

The transcription factor Tfap2e/AP-2ε plays a pivotal role in maintaining the identity of basal vomeronasal sensory neurons

Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice

Gene duplication, conservation, and divergence of activating transcription factor 5 gene in zebrafish

Contact Info

Product

Resources

About