Activation in dorsolateral prefrontal cortex in response to maternal criticism and praise in recovered depressed and healthy control participants

Hooley, Jill M.; Gruber, Staci A.; Scott, Laurie; Hiller, Jordan B.; Yurgelun‐Todd, Deborah

doi:10.1016/j.biopsych.2005.01.012

Cited by 125 publications

(100 citation statements)

References 15 publications

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“…These findings fit well with that of increased DLPFC activation observed to external criticism (Hooley et al, 2005). Hooley et al (2005) played taped statements of either maternal praise or maternal criticism to recovered depressed and healthy control participants. They found that control subjects showed bilateral activation of the DLPFC to both praise and criticism, whilst recovered depressed people had a similar response to maternal praise but negligible activation of DLPFC to criticism.…”

Section: Introductionsupporting

confidence: 80%

“…Additionally, the lateral PFC (including orbitofrontal cortex; OFC) has been associated with the inhibition of inappropriate behaviour and the facilitation of appropriate behaviour (Miller and Cohen, 2001). These findings fit well with that of increased DLPFC activation observed to external criticism (Hooley et al, 2005). Hooley et al (2005) played taped statements of either maternal praise or maternal criticism to recovered depressed and healthy control participants.…”

Section: Introductionsupporting

confidence: 58%

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Having a word with yourself: Neural correlates of self-criticism and self-reassurance

et al. 2010

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Self-criticism is strongly correlated with a range of psychopathologies, such as depression, eating disorders and anxiety. In contrast, self-reassurance is inversely associated with such psychopathologies. Despite the importance of self-judgements and evaluations, little is known about the neurophysiology of these internal processes. The current study therefore used a novel fMRI task to investigate the neuronal correlates of selfcriticism and self-reassurance. Participants were presented statements describing two types of scenario, with the instruction to either imagine being self-critical or self-reassuring in that situation. One scenario type focused on a personal setback, mistake or failure, which would elicit negative emotions, whilst the second was of a matched neutral event. Self-criticism was associated with activity in lateral prefrontal cortex (PFC) regions and dorsal anterior cingulate (dAC), therefore linking self-critical thinking to error processing and resolution, and also behavioural inhibition. Self-reassurance was associated with left temporal pole and insula activation, suggesting that efforts to be self-reassuring engage similar regions to expressing compassion and empathy towards others. Additionally, we found a dorsal/ventral PFC divide between an individual's tendency to be self-critical or self-reassuring. Using multiple regression analyses, dorsolateral PFC activity was positively correlated with high levels of self-criticism (assessed via self-report measure), suggesting greater error processing and behavioural inhibition in such individuals. Ventrolateral PFC activity was positively correlated with high self-reassurance. Our findings may have implications for the neural basis of a range of mood disorders that are characterised by a preoccupation with personal mistakes and failures, and a self-critical response to such events.

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Section: Introductionsupporting

confidence: 80%

Section: Introductionsupporting

confidence: 58%

Having a word with yourself: Neural correlates of self-criticism and self-reassurance

et al. 2010

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“…For example, Hooley and coworkers (Hooley, Gruber, Scott, Hiller, & Yurgelun-Todd, 2005;Hooley et al, 2009) have demonstrated that, relative to healthy controls, symptom free formerly depressed individuals responded to criticism with less activation in the DLPFC and increased activation in the amygdala.…”

Section: Cognitive Control and Emotion Reactivitymentioning

confidence: 99%

The role of expectancy and proactive control in stress regulation: A neurocognitive framework for regulation expectation

Raedt

Hooley

2016

Clinical Psychology Review

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When confronted with stressful or emotionally arousing situations, regulatory abilities should allow us to adaptively cope. However, depressed individuals often have a low sense of perceived control and are characterized by a negative expectation bias regarding their ability to deal with future stressful events. Low expectancy concerning the ability to deal with future stressful events may result in less initiation of proactive control, a crucial mechanism of cognitive control reflecting sustained and anticipatory maintenance of goal-relevant information in the dorsolateral prefrontal cortex to optimize cognitive performance. In this theoretical review we integrate a diverse body of literature. We argue that the expectancy of an individual's regulatory abilities prior to the presentation of an arousing event or stressful task will be related to anticipation and proactive up-or down regulation of specific neurocircuits before the actual encounter with the stressful event occurs, in a manner that can be either adaptive or maladaptive. Moreover, we discuss the important role of self-esteem as well as the ability to accept the situation when coping is not possible. Our approach has implications for a broad range of disorders and conditions in which stress regulation plays a role, and can be used to guide the use of recently developed clinical interventions, as well as to fine-tune interventions to facilitate proactive control. Cortex, stress regulation, anticipation, depression, proactive control, coping, self-esteem, When we are confronted with situations or thoughts perceived as unpleasant, aversive or threatening, a series of biological and psychological processes is activated, generating a coordinated response. This so-called stress response is triggered when an individual's well-being or health is threatened. Relational or financial problems, unpredictability, an acute threat, or a challenging situation such as a job interview are examples of stressful situations or stressors that can initiate a stress response. Regulatory abilities, which we call stress regulation, generally allow us to cope with these situations in an adaptive way. However, there are large individual differences in how well people handle life stressors. Indeed, problems with stress regulation are thought to play a central role in the development and clinical course of depression (Hooley, Orley & Teasdale, 1986;Hankin, 2008;Morris, Ciesla & Garber, 2010). It has also been suggested that, over time, depressive episodes can be triggered by progressively milder and milder stressors (Monroe & Harkness, 2005; but see also Anderson et al., 2016). Keywords: Dorsolateral PrefrontalResearch shows the important role of stress regulation in the development of different forms of psychopathology, such as depression, where psychosocial stressors are strongly implicated in the triggering of new episodes (Kendler et al., 2000).Understanding the role of stressors in depression requires consideration of the interaction between biological, cognitive ...

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“…63 Alternatively, a recent functional imaging study involving a social challenge paradigm found that healthy control subjects activated the DLPFC in response to hearing critical remarks, whereas fully remitted MDD subjects failed to activate this area. 64 The possibility remains that a subtle trait-related dysfunction in the DLPFC could predispose to depression in at least a subset of those with mood disorders.…”

Section: Functional Anatomy Of Mood Disordersmentioning

confidence: 99%

Neural circuitry and neuroplasticity in mood disorders: Insights for novel therapeutic targets

Carlson¹,

Singh²,

Zarate³

et al. 2006

NeuroRX

136

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Summary:Major depressive disorder and bipolar disorder are severe mood disorders that affect the lives and functioning of millions each year. The majority of previous neurobiological research and standard pharmacotherapy regimens have approached these illnesses as purely neurochemical disorders, with particular focus on the monoaminergic neurotransmitter systems. Not altogether surprisingly, these treatments are inadequate for many individuals afflicted with these devastating illnesses. Recent advances in functional brain imaging have identified critical neural circuits involving the amygdala and other limbic structures, prefrontal cortical regions, thalamus, and basal ganglia that modulate emotional behavior and are disturbed in primary and secondary mood disorders. Growing evidence suggests that mechanisms of neural plasticity and cellular resilience, including impairments of neurotrophic signaling cascades as well as altered glutamatergic and glucocorticoid signaling, underlie the dysregulation in these circuits. The increasing ability to monitor and modulate activity in these circuits is beginning to yield greater insight into the neurobiological basis of mood disorders. Modulation of dysregulated activity in these affective circuits via pharmacological agents that enhance neuronal resilience and plasticity, and possibly via emerging nonpharmacologic, circuitry-based modalities (for example, deep brain stimulation, magnetic stimulation, or vagus nerve stimulation) offers promising targets for novel experimental therapeutics in the treatment of mood disorders.

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Activation in dorsolateral prefrontal cortex in response to maternal criticism and praise in recovered depressed and healthy control participants

Cited by 125 publications

References 15 publications

Having a word with yourself: Neural correlates of self-criticism and self-reassurance

Having a word with yourself: Neural correlates of self-criticism and self-reassurance

The role of expectancy and proactive control in stress regulation: A neurocognitive framework for regulation expectation

Neural circuitry and neuroplasticity in mood disorders: Insights for novel therapeutic targets

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