2021
DOI: 10.1016/j.jcin.2021.06.041
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ACTIVATION (PercutAneous Coronary inTervention prIor to transcatheter aortic VAlve implantaTION)

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Cited by 151 publications
(102 citation statements)
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“…Expert consensus opinion (class IIa, level of evidence C) highlights that percutaneous coronary intervention (PCI) should be considered in AS-patients with a primary indication to undergo TAVR who have stenosis of at least 70% DS in the proximal segments of epicardial coronary arteries that subtend a large area of myocardium at risk (7,10). This has been recently challenged with the results from the Assessing the Effects of Stenting in Significant Coronary Artery Disease Prior to Transcatheter Aortic Valve Implantation (ACTIVATION) trial (26). Obviously, the optimal management of AS-patients with concomitant CAD in patients undergoing TAVR remains controversial due to the heterogeneity of available data, and the clinical relevance of PCI performed before or immediately after TAVR remains to be determined (2,5,(27)(28)(29).…”
Section: Introductionmentioning
confidence: 99%
“…Expert consensus opinion (class IIa, level of evidence C) highlights that percutaneous coronary intervention (PCI) should be considered in AS-patients with a primary indication to undergo TAVR who have stenosis of at least 70% DS in the proximal segments of epicardial coronary arteries that subtend a large area of myocardium at risk (7,10). This has been recently challenged with the results from the Assessing the Effects of Stenting in Significant Coronary Artery Disease Prior to Transcatheter Aortic Valve Implantation (ACTIVATION) trial (26). Obviously, the optimal management of AS-patients with concomitant CAD in patients undergoing TAVR remains controversial due to the heterogeneity of available data, and the clinical relevance of PCI performed before or immediately after TAVR remains to be determined (2,5,(27)(28)(29).…”
Section: Introductionmentioning
confidence: 99%
“…However, there was a higher rate of bleeding in the PCI group (44.5% versus 28.4%, p=0.02) in the first 30 days after the TAVI procedure. [ 43 ]…”
Section: Intervention In Tavi Patientsmentioning
confidence: 99%
“…The ACTIVATION trial (RCT,n:235) compared PCI vs no-PCI prior to TAVR in patients with severe aortic stenosis and obstructive CAD. The observed rates of death (13.4% vs 12.1%) and rehospitalization at 1 year (34.5% vs 33.6%) were similar between PCI and no PCI prior to TAVR; however, the non-inferiority margin was not met, and PCI resulted in a higher incidence of bleeding (41.2% vs 21.7%) [ 11 ]. The majority of bleeding occurred in the first 30 days after TAVR.…”
Section: Introductionmentioning
confidence: 99%