Active and Inactive Forms of the Hormone Promoting Comb Growth

Adler, A. A.

doi:10.1038/133798a0

Cited by 15 publications

(2 citation statements)

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“…Since Adler [1934] demonstrated convincingly that the androgenic sub¬ stances in urine, like the oestrogenic substances, occur in the form of conju¬ gated, water-soluble compounds, from which they required to be liberated by heating with mineral acid before extraction with fat solvents, this pro¬ cess of hydrolysis forms part of all the recognized methods of extraction.…”

Section: Conditions Of Hydrolysis Of Urine By Acid Under Varying Condmentioning

confidence: 99%

Methods of Extracting Compounds Related to the Steroid Hormones From Human Urine

Callow¹,

Callow²,

Emmens³

et al. 1939

Journal of Endocrinology

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At the beginning of biochemical work on male hormones it was assumed that the androgenic material which could be extracted from normal male urine was`the male hormone', or 'the testicular hormone'. On this supposition, it was hoped that the biological assay of urine extracts would give an index of the activity of androgenic substances in the human body, possibly referable to the level of testicular secretion. It is for this reason that the separation of the maximal androgenic activity as measured by capon comb-growth has been taken as the criterion of a satisfactory extraction in the methods developed by systematic work in various laboratories. It has since been realized, however, that androgenic activity is not specific to one substance, and that at least two related compounds with androgenic activity are present in the mixture of neutral compounds which can be prepared from urine. Further, these two compounds, androsterone and ¿ratts-dehydroandrosterone (¿35-androsten-3(/3)-ol-17-one), which can be isolated from the urine of women as well as from the urine of men [Callow and Callow, 1938], have not been found in tissue, whilst the only androgen isolated as yet from testis tissue, testosterone, has not been found in urine.

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Section: Conditions Of Hydrolysis Of Urine By Acid Under Varying Condmentioning

confidence: 99%

Methods of Extracting Compounds Related to the Steroid Hormones From Human Urine

Callow¹,

Callow²,

Emmens³

et al. 1939

Journal of Endocrinology

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“…Venning & Brown (45) have isolated pregnandiol glucuro nide. The work of Adler (46) suggests that a portion of the andro genic substance, the male hormone, also appears to be present in the urine as a conjugated and inactive compound.…”

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confidence: 98%

Detoxication Mechanisms

Quick¹

1937

Annu. Rev. Biochem.

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From the trend of the current biological literature, one can discern the beginning of a realization that the so�called detoxication mecha nisms are not isolated biochemical curiosities, but probably constitute vital processes in the body economy. An attempt will therefore be made in this review to interpret the various results, often of highly divergent types of research, as contributions aiding in the solution of more or less concise and circumscribed physiological problems, rather than merely listing results under the well�known and estab� lished headings.

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