Active and Passive Smokers - A Haematobiochemical and Cytogenetic Study

Sasikala, K.; Rosalin, F. Regina; Jude, A.L. Calistus; Kumar, R. Ashok; Sudha, S.; Devi, Monika; Balachandar, N.; Beegam, Sajeetha K.A.; Meenakshi, N.; Begum, A. Asia

doi:10.1080/09723757.2003.11885824

Cited by 11 publications

(5 citation statements)

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“…An elevated level of CA frequency shows 80% increased risk of cancer 37 . Active smokers posses higher level of CAs than the passive smokers 38 . Smoking habit as an imperative part that induces the significant alterations in the genomic material 8,9 .…”

Section: Discussionmentioning

confidence: 84%

Genotoxic effects of tobacco use in residents of hilly areas and foot hills of Western Ghats, Southern India

Chandirasekar¹,

Murugan

Muralisankar

et al. 2019

Sci Rep

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Smoking and smokeless tobacco consumption is a significant risk factor that provokes genetic alterations. The present investigation was to evaluate the biomarkers of genotoxicity including micronucleus (MN), chromosome aberrations (CA) and DNA strand breaks among tobacco consumers and control individuals residing in hilly areas of Western Ghats, Tamilnadu, South India. This study included 268 tobacco consumers with equal number of controls. The tobacco consumers were divided into Group I (<10 years of tobacco consumption with an age range from 15 to 35 years) and group II (>10 years consumption above 35 years of age). Chromosome aberration (CA) and comet assay were performed using blood and micronucleus assay from exfoliated buccal epithelial cells obtained from tobacco consumers and controls. Elevated levels of CA were found in group II (Chromatid type: 2.39 ± 1.13 and chromosome type: 1.44 ± 1.24) exposed subjects, high micronucleus and DNA damage (TL:4.48 ± 1.24 and TM:3.40 ± 1.58) levels were significantly (p < 0.05) observed in both smoking and smokeless tobacco consumers when comparison with group I and controls. This study also observed a lack of awareness among the tobacco consumers about the harmful health effects of tobacco. Tobacco consumption contributes to the significant alteration in genetic materials. In addition, a high rate of spontaneous abortion was also seen in the studied population.

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Section: Discussionmentioning

confidence: 84%

Genotoxic effects of tobacco use in residents of hilly areas and foot hills of Western Ghats, Southern India

Chandirasekar¹,

Murugan

Muralisankar

et al. 2019

Sci Rep

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“…Although former cigarette smokers were more likely than those who had never smoked to have a smokeless tobacco lesion, we found little evidence for an independent effect of cigarette smoking and alcohol consumption on the presence of these lesions. Sasikala et al, 2003). Jayakumar and Sasikala (2008) reported cigarette smoking routine has a synergistic effect on inducing DNA damage among the jewellery workers are occupationally exposed to nitric oxide.…”

Section: Resultsmentioning

confidence: 99%

DNA Damage in Workers Occupationally Exposed to Lead, Using Comet Assay

Pappuswamy¹,

Balachandar²,

Sasikala³

2010

IJB

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Lead is one of the most clinically important heavy metals, because it induces a broad range of physiological,
biochemical, and genetical dysfunctions. Occupational exposure to lead leads to increased frequency of genetic system
in human beings. In the present study the DNA damage among the workers occupationally exposed to lead was
analyzed using peripheral blood lymphocyte by comet assay. The result of this study shows increased levels of DNA
damage among experimental subjects. The habit of cigarette smoking among the workers has a synergistic effect on
inducing DNA damage.

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“…These conditions are associated with impairment in the balance between cell growth and cell death and collectively cause high rates of morbidity and mortality in today's society [3]. Tobacco has both acute and chronic effects on hematological parameters and physiological alteration in human body [4,5]. Smoking is a familiar cause of the increase in hemoglobin (Hb) concentration that is believed to be mediated by the exposure to carbonmonoxide.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Cigarette Smoking on Blood and Biochemical Parameters: A Comparative Study Among Male Smokers and Non-Smokers In Baghdad City

Jaafar

2020

eijs

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The impact of smoking on human health is remarkable and can lead to death. This research was performed to test the effects of cigarette smoking on some parameters that are considered as signs of critical problems in human body. The study was carried out on fifty Iraqi male smokers in Baghdad city, who smoked at least 10 cigarettes per day for at least 15 years. The group includes 25 male smokers with an age range of 20 -55 years and 25 male non-smokers who were collected with the same range of age for statistical comparison. The results of the study revealed significant increases in blood parameters, including hemoglobin (Hb, 16.0917 (g/dl) , packed cell volume (PCV, 49.2%), red blood cells (RBC, 5.4763 X1012/L), white blood cell (WBC, 12.5565 X109/L), and platelet (PLT, 430.000 x1012/L). Similar effects were observed in relation to the serum biochemical parameters o of kidney function (urea, 53.2400 mg/ dl; creatinine, 1.5480 mg/ dl) as well as liver function (alanine aminotransferase, ALT, 104.9200 U/l; aspartate transaminase, AST, 122.3040 U/l; alkaline phosphatase, ALP, 337.4000U/l); total serum bilirubin, TSB, 0.6780 mg/ dl). However, significantly decreased levels of total protein (60.6800 mg/ dl) and uric acid (4.2400 mg/ dl) were recorded in cigarette smokers when compared with non-smokers group.

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Active and Passive Smokers - A Haematobiochemical and Cytogenetic Study

Cited by 11 publications

References 1 publication

Genotoxic effects of tobacco use in residents of hilly areas and foot hills of Western Ghats, Southern India

Genotoxic effects of tobacco use in residents of hilly areas and foot hills of Western Ghats, Southern India

DNA Damage in Workers Occupationally Exposed to Lead, Using Comet Assay

The Effect of Cigarette Smoking on Blood and Biochemical Parameters: A Comparative Study Among Male Smokers and Non-Smokers In Baghdad City

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