Active at night, sleepy all day – Sleep disturbances in patients with hepatitis C virus infection

Heeren, Meike; Sojref, Faina; Schuppner, Ramona; Worthmann, Hans; Pflugrad, Henning; Tryc, Anita Blanka; Pasedag, Thomas; Weißenborn, Karin

doi:10.1016/j.jhep.2013.11.030

Cited by 39 publications

(37 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HCV PCR‐positive and HCV PCR‐negative patients did not show any significant differences. Our results are supported by previous studies but are in contrast to the results by Byrnes et al . .…”

Section: Discussionsupporting

confidence: 84%

“…Interestingly, these symptoms are independent from the grade of liver disease and virus replication rate . Even HCV PCR‐negative patients suffer from neuropsychiatric symptoms and have been shown to score similarly to HCV PCR‐positive patients with neuropsychiatric symptoms in neuropsychological tests . The cause of HCV infection associated neuropsychiatric symptoms is unclear.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cerebral microglia activation in hepatitis C virus infection correlates to cognitive dysfunction

Pflugrad

Meyer

Dirks

et al. 2016

Journal of Viral Hepatitis

View full text Add to dashboard Cite

Hepatitis C virus (HCV) infection may induce chronic fatigue and cognitive dysfunction. Virus replication was proven within the brain and HCV-positive cells were identified as microglia and astrocytes. We hypothesized that cerebral dysfunction in HCV-afflicted patients is associated with microglia activation. Microglia activation was assessed in vivo in 22 patients with chronic HCV infection compared to six healthy controls using [(11) C]-PK11195 Positron Emission Tomography (PET) combined with magnetic resonance tomography for anatomical localization. Patients were subdivided with regard to their PCR status, Fatigue Impact Scale score (FIS) and attention test sum score (ATS). A total of 12 patients (54.5%) were HCV PCR positive [of which 7 (58.3%) had an abnormal FIS and 7 (58.3%) an abnormal ATS], 10 patients (45.5%) were HCV PCR negative (5 (50%) each with an abnormal FIS or ATS). Patients without attention deficits showed a significantly higher accumulation of [(11) C]-PK11195 in the putamen (P = 0.05), caudate nucleus (P = 0.03) and thalamus (P = 0.04) compared to controls. Patients with and without fatigue did not differ significantly with regard to their specific tracer binding in positron emission tomography. Preserved cognitive function was associated with significantly increased microglia activation with predominance in the basal ganglia. This indicates a probably neuroprotective effect of microglia activation in HCV-infected patients.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Cerebral microglia activation in hepatitis C virus infection correlates to cognitive dysfunction

Pflugrad

Meyer

Dirks

et al. 2016

Journal of Viral Hepatitis

View full text Add to dashboard Cite

show abstract

“…With regards to the physical activity data, only few studies have availed of actigraphy for capturing activity patterns in HCV‐infected patients . To date, Heeren et al assessed motion drive and intensity of physical activity by actigraphy and detected no differences when comparing patients with hepatitis C to healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…The actigraph monitor CT3X is used for reliable monitoring of physical activity . It measures inter alia the intensity of motion, the number of daily steps and individual energy consumption.…”

Section: Methodsmentioning

confidence: 99%

Antidepressant effects of direct‐acting antivirals against hepatitis C virus—Results from a pilot study

Hahn

Stokes

Kaiser

et al. 2018

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…These pathological changes correlate with the grade of liver dysfunction[102-105]. Insomnia is also reported by 50%-65% of cirrhotic patients and excessive daytime sleepiness is part of the hepatic encephalopathy syndrome[105,106]. Physicians should perform a routine assessment of sleep quality and time and evaluate daytime sleepiness.…”

Section: Best Supportive Carementioning

confidence: 99%

Challenges of advanced hepatocellular carcinoma

Colagrande

Inghilesi

Aburas

et al. 2016

WJG

151

115

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is an aggressive malignancy, resulting as the third cause of death by cancer each year. The management of patients with HCC is complex, as both the tumour stage and any underlying liver disease must be considered conjointly. Although surveillance by imaging, clinical and biochemical parameters is routinely performed, a lot of patients suffering from cirrhosis have an advanced stage HCC at the first diagnosis. Advanced stage HCC includes heterogeneous groups of patients with different clinical condition and radiological features and sorafenib is the only approved treatment according to Barcelona Clinic Liver Cancer. Since the introduction of sorafenib in clinical practice, several phase III clinical trials have failed to demonstrate any superiority over sorafenib in the frontline setting. Loco-regional therapies have also been tested as first line treatment, but their role in advanced HCC is still matter of debate. No single agent or combination therapies have been shown to impact outcomes after sorafenib failure. Therefore this review will focus on the range of experimental therapeutics for patients with advanced HCC and highlights the successes and failures of these treatments as well as areas for future development. Specifics such as dose limiting toxicity and safety profile in patients with liver dysfunction related to the underlying chronic liver disease should be considered when developing therapies in HCC. Finally, robust validated and reproducible surrogate end-points as well as predictive biomarkers should be defined in future randomized trials.

show abstract

Active at night, sleepy all day – Sleep disturbances in patients with hepatitis C virus infection

Cited by 39 publications

References 41 publications

Cerebral microglia activation in hepatitis C virus infection correlates to cognitive dysfunction

Cerebral microglia activation in hepatitis C virus infection correlates to cognitive dysfunction

Antidepressant effects of direct‐acting antivirals against hepatitis C virus—Results from a pilot study

Challenges of advanced hepatocellular carcinoma

Contact Info

Product

Resources

About