This paper presents three configurations of broadband differentially fed microstrip antenna for GSM1800, 1900 and 2100 MHz. The antennas are designed and fabricated using two different substrates for bottom and upper layer. The three antennas designed and tested have gain of 9.88, 9.66, and 11.14 dBi, respectively, at the center frequency. The proposed antennas also find its implementation in areas where, differential inputs/outputs wireless communication circuits are needed. Later, a differentially driven RF power harvesting system with maximum efficiency of 71%, 67% and 78% for a load of 520 Ω is also designed and developed.