Active components and biological functions of royal jelly

Guo, Jianying; Wang, Zixu; Chen, Yaoxing; Cao, Jing; Tian, Wenli; Ma, Baochen; Dong, Yulan

doi:10.1016/j.jff.2021.104514

Cited by 70 publications

(59 citation statements)

References 121 publications

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“…Active ingredients, such as 10-HDA and major royal jelly proteins, play an important role in anticancer, antibacterial, immune regulation, etc. [ 32 ]. IBD includes CD and UC [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Royal Jelly Protected against Dextran-Sulfate-Sodium-Induced Colitis by Improving the Colonic Mucosal Barrier and Gut Microbiota

Guo

Wang

et al. 2022

Nutrients

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Royal jelly (RJ) is a natural bee product that contains a variety of biologically active ingredients and has antitumor, antiallergic, antibacterial and immune-regulating effects. Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestine that can cause abdominal pain and diarrhea. With this study, we aimed to explore the protective effect of RJ on DSS-induced colitis in mice. The physiochemical parameters (water, protein, 10-hydroxy-2-decenoic acid, total sugar, starch, ash and acidity) of the RJ samples used in this study met the requirements of the international and Chinese national standards. Treatment with RJ improved symptoms and colonic cell apoptosis and decreased intestinal permeability by increasing the expression of tight-junction protein, goblet cells and their secretion mucin, MUC2, in DSS-induced ulcerative colitis mice. RJ also reduced the expression of proinflammatory cytokine IL-6 and increased the expression of anti-inflammatory cytokine IL-10 and sIgA. DSS resulted in an increase in the relative abundance of Parabacteroides, Erysipelotrichaceae, Proteobacteria (Gammaproteobacteria, Enterobacteriales and Enterobacteriaceae) and Escherichia Shigella in the colon and a decrease in the relative abundance of Muribaculum. In the RJ treatment group, the relative abundance of the above intestinal flora was improved by treatment with 2.0 g/kg RJ. These results suggested that RJ alleviated DSS-induced colitis by improving the colonic mucosal barrier.

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“…Active ingredients, such as 10-HDA and major royal jelly proteins, play an important role in anticancer, antibacterial, immune regulation, etc. [ 32 ]. IBD includes CD and UC [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Royal Jelly Protected against Dextran-Sulfate-Sodium-Induced Colitis by Improving the Colonic Mucosal Barrier and Gut Microbiota

Guo

Wang

et al. 2022

Nutrients

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“…Synthesizing royal jelly into mass reared insect diets must be cost effective but also maintain or increase the gustatory appeal of the diet. Royal jelly is rich in free amino acids (Guo et al 2021), and female G. sigillatus feeding time increases with spermatophylax amino acid concentration (Warwick et al 2009) thus increasing the total amount of ejaculate transferred to females. Diet can have a strong influence on male G. sigillatus fitness (Duffield et al 2020), and male mating success is maximized on diets slightly higher in protein than carbohydrates (Rapkin et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Fruitful female fecundity after feedingGryllodes sigillatusroyal jelly

Muzzatti

McConnell

Neave

et al. 2022

Preprint

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Dietary honey bee royal jelly increases insect growth rates and adult body size. Royal jelly could enhance mass insect production as a dietary supplement, but it is costly to produce. The mechanisms underlying the effects of royal jelly on growth remain unclear, and so it is valuable to understand the effects of royal jelly on a mass reared model species to try and augment body size in a more cost-effective manner. To determine the effect of royal jelly on a cricket species (Gryllodes sigillatus) farmed on mass for human consumption, we ran two experiments. In one experiment we tested the dose-dependent response of Gryllodes sigillatus to royal jelly using a range of diets across 0-30% w/w royal jelly. In another experiment we measured the individual-level life history responses of Gryllodes sigillatus to royal jelly over time by individually rearing freshly-hatched Gryllodes sigillatus on two separate diets: half were fed a commercially available cricket diet, while the other half were fed the same diet mixed with 15% w/w fresh royal jelly. Body size and mass measurements were recorded weekly for five weeks. We found the effects of royal jelly to be sex-dependent within crickets: females fed the royal jelly diet grew to be 30% heavier, and this effect was driven by significantly longer abdomens containing 67% more eggs compared to those fed the basal diet. There was a higher probability of crickets reaching adulthood after 35 days when fed royal jelly, and female mass was optimised at approximately 17% w/w royal jelly. Our results reveal that while a royal jelly dietary supplement can increase the yield of mass-reared insects, the life-history responses are species- and sex-specific.

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“…Royal jelly has been widely used in commercial medical products, health foods, and cosmetics in many countries for more than 30 years [ 117 ]. A recent review by Guo et al [ 118 ] summarised the biologically active role of royal jelly in the maintenance of biological functions, such as immunity, lifespan, memory, digestive system, blood glucose, obesity, antibacterial, and anti-cancer properties [ 116 ]. Ahmad et al [ 114 ] provided new insights into the biological and pharmaceutical properties, such as antimicrobial, antioxidant, wound healing, immunomodulatory, anti-aging, anti-cancer, anti-inflammatory, anti-hypertension, anti-hyperlipidemic, oestrogenic, and neurotrophic effects of royal jelly.…”

Section: Use Of Bee Products As Raw Materials and Medicinal Resourcesmentioning

confidence: 99%

The Honey Bee Apis mellifera: An Insect at the Interface between Human and Ecosystem Health

Papa

Maier

Durazzo³

et al. 2022

Biology

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The concept of ecosystem services is widely understood as the services and benefits thatecosystems provide to humans, and they have been categorised into provisioning, regulating, supporting, and cultural services. This article aims to provide an updated overview of the benefits that the honey bee Apis mellifera provides to humans as well as ecosystems. We revised the role of honey bees as pollinators in natural ecosystems to preserve and restore the local biodiversity of wild plants; in agro-ecosystems, this species is widely used to enhance crop yield and quality, meeting the increasing food demand. Beekeeping activity provides humans not only with high-quality food but also with substances used as raw materials and in pharmaceuticals, and in polluted areas, bees convey valuable information on the environmental presence of pollutants and their impact on human and ecosystem health. Finally, the role of the honey bee in symbolic tradition, mysticism, and the cultural values of the bee habitats are also presented. Overall, we suggest that the symbolic value of the honey bee is the most important role played by this insect species, as it may help revitalise and strengthen the intimate and reciprocal relationship between humans and the natural world, avoiding the inaccuracy of considering the ecosystems as mere providers of services to humans.

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Active components and biological functions of royal jelly

Cited by 70 publications

References 121 publications

Royal Jelly Protected against Dextran-Sulfate-Sodium-Induced Colitis by Improving the Colonic Mucosal Barrier and Gut Microbiota

Royal Jelly Protected against Dextran-Sulfate-Sodium-Induced Colitis by Improving the Colonic Mucosal Barrier and Gut Microbiota

Fruitful female fecundity after feedingGryllodes sigillatusroyal jelly

The Honey Bee Apis mellifera: An Insect at the Interface between Human and Ecosystem Health

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