Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells

Chen, Hua-Chien; Chou, Chen‐Kung; Lee, Shou‐Dong; Wang, Ju-Chun; Yeh, Sheau-Farn

doi:10.1016/0166-3542(94)00083-k

Cited by 177 publications

(113 citation statements)

References 23 publications

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“…Furthermore, costunolide potentiated 1,25-(OH)2D3-induced differentiation in HL-60 promyelocytic leukemia cells (Choi et al, 2002b;Kim et al, 2008;Kim et al, 2002), via the interference with NF-κB activation. Further studies demonstrate that costunolide has antitumor potential by inhibiting proliferation, inducing apoptosis and reducing invasion and metastasis of a wide variety of tumor cells, including breast cancer cells (Bocca et al, 2004;Choi et al, 2005;Choi et al, 2011), hepatocellular carcinoma cells (Chen et al, 1995;Liu et al, 2011a;Sun et al, 2003), prostate cancer cells (Hsu et al, 2011), leukemia cells (Choi et al, 2002a;Choi and Lee, 2009;Choi et al, 2002b;Hibasami et al, 2003;Kanno et al, 2008;Kim et al, 2008;Kim et al, 2002;Kim et al, 2011b;Komiya et al, 2004;Lee et al, 2001;Song et al, 2001;Srivastava et al, 2006), gastric cancer cells (Ko et al, 2005;Rasul et al, 2011), colon cancer cells (Kawamori et al, 1995;Mori et al, 1994), melanoma cells (Chen et al, 2007;Park et al, 2001b), cervical cancer cells (Sun et al, 2003), KB and P388 tumor cell (Mondranondra et al, 1990), and platinum-resistant human ovarian cancer cells . It was also reported that costunolide inhibited angiogenic response by blocking the angiogenic factor signaling pathway (Jeong et al, 2002) and microtubule-interactting activity of costunolide (Bocca et al, 2004).…”

Section: Biological Functionsmentioning

confidence: 99%

“…As a medicine, costunolide is a famous sesquiterpene lactone, which is used as popular herbal remedies, with anti-ulcer (Matsuda et al, 2002;Pandey et al, 2007), anti -inflammatory (Kassuya et al, 2009;Macias et al, 1999;Mondranondra et al, 1990;Pae et al, 2007;Park et al, 1996;Song et al, 2001;Stefani et al, 2006), anti-fungal (Barrero et al, 2000;Kang et al, 2004;Wedge et al, 2000), anti-viral properties (Chen et al, 1995), Antipyretic (Kassuya et al, 2009), antimycobacterial activities (Fischer et al, 1998;Luna-Herrera et al, 2007), and inhibition of the cellular production of melanin (Choi et al, 2008), human lamin-B by farnesyl-protein transferase (FPTase) (Park et al, 2001b), and protein tyrosine phosphatase 1B (hPTP1B) (Li et al, 2006). Costunolide exhibited strong larvicidal activity against A. albopictus (Liu et al, 2011b).…”

Section: Biological Functionsmentioning

confidence: 99%

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Costunolide: A novel anti-cancer sesquiterpene lactone

Rasul

Parveen

2012

Bangladesh J Pharmacol

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Costunolide: A novel anti Costunolide: A novel anti Costunolide: A novel anti---cancer cancer cancer sesquiterpene lactone sesquiterpene lactone sesquiterpene lactone BJP IntroductionCancer is the leading cause of death and represents one of the most threatening diseases worldwide. In the recent report, it has been estimated that 12.7 million new cancer cases and 7.6 million cancer deaths occur in 2008, with 56% of new cancer cases and 63% of the cancer deaths occurring in the less developed regions of the world (Ferlay et al., 2010). Throughout the history of civilization, the human have relied on natural products as a primary source of medicine. Herbal medicines have been proven to be an important source of novel agents with a pharmaceutical potential. Many anti-cancer drugs in current use are either natural products or are derived from natural products. Herbal medicines, such as paclitaxel, camptothecin, vinca alkaloids, and etoposide hold great potential as promising agents for the treatment of cancer (Cragg and Newman, 2005). Natural products have tradition-ally provided a rich source of drugs for many diseases, including cancer and plants are an important source of novel natural products (Amin et al., 2009). In 2008, of the 225 drugs being developed, 164 were of natural origin, with 108 being derived from plants, 25 from bacterial sources, 7 from fungal and 24 from animal sources. And, to throw some more numbers around, of the 108 plant-based drugs, 46 were in preclinical development, 14 in phase I, 41 in phase II, 5 in phase III and two had already reached pre-registration stage (Harvey, 2008). David Newman and Gordon Cragg (Newman and Cragg, 2007) found that of 155 FDA-approved small molecule anti-cancer drugs, 47% were either natural products or directly derived there from.C o s t u n o l i d e ( 6 E , 1 0 E , 1 1 a R ) -6 , 1 0 -d i m e t h y l -3 -methylidene-3a, 4,5,8,9,11a-hexahydrocyclodeca [b] furan-2-one) is a sesquiterpene lactone. It is a colorless crystalline powder with molecular formula of C15H20O2 and molecular weight of 232.318 g/mol (Figure 1). This review is aimed to summarize the recent researches on costunolide focusing on anti-cancer activity and to lay emphasis on molecular mechanisms which suggests a promising for such pursuits in oncology. Literature was searched through Pub Med, Scopus and Elsevier Science Direct Journal. Access to the Elsevier Science Direct Journal was made possible through library of AbstractCurrently an ample interest is found among oncologists to explore anti-cancer compounds from herbs. Sesquiterpene lactones have accredited significant attention in pharmacological research. Costunolide is a well-known sesquiterpene lactone present in plants used as popular herbal remedy. Several plantderived compounds are currently successfully employed in cancer treatment. Growing evidences demonstrated that costunolide possesses anti-cancer activities by inhibiting cell proliferation, tumor invasion, angiogenesis, metastasis and inducing apoptosis of a variety of tumor...

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Section: Biological Functionsmentioning

confidence: 99%

Section: Biological Functionsmentioning

confidence: 99%

Costunolide: A novel anti-cancer sesquiterpene lactone

Rasul

Parveen

2012

Bangladesh J Pharmacol

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“…It was reported that both costunolide and dehydrocostus lactone suppressed the HBsAg production by Hep3B cells in a dose dependent manner [10]. The in vitro antiviral activity of SC root against hepatitis B virus had been reported [23]. There is, however, no reported in vivo activity related to liver damage in guinea pigs.…”

mentioning

confidence: 84%

“…Saussurea costus is considered to be one of the antioxidant-rich medicinal plants. Many authors have reported that the roots of this plant possess various biological activities, including cortisol lowering effect [38], anti-infammatory [39,40], anticancer [41,42], antiviral [23], antimicrobial [43,44], antifungal [15], antioxidant [45,46], antidiabetic [47], antiulcer [20] and hepatoprotective effects [38]. Liv-52 is widely used in treatment of liver diseases of varying origins.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Costus Roots Extract against Carbon Tetrachloride (CCl4)-Induced Liver Injury in Guinea Pigs

Al-Duais¹,

Al-Awthan²

2017

JLS

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SC (Saussurea costus) (Asteraceae) is a traditionally known and potent plant which is well considered for its medicinal uses in different indigenous Indian systems of medicine. This study was undertaken to investigate the hepatoprotective effect of SC against liver injury induced by CCl 4 intoxication. Animals were divided into five groups. Group I, served as normal control. Group II received 2 mL CCl 4 /kg b.w. diluted with olive oil, at 1:1 ratio on day 11. Groups III and IV were pre-treated orally respectively with 100 and 200 mg/kg b.w. aqueous roots extract of SC for 10 days followed by subcutaneous injection of CCl 4 (2 mL/kg b.w.), once on day 11. Group V were orally given Liv-52 (100 mg/kg b.w.) once daily for 10 days followed by subcutaneous injection of CCl 4 (2 mL/kg b.w.), once on day 11. Our results show that, the activity of serum hepatic enzymes (ALT, AST, and ALP) were significantly elevated in guinea pigs treated with CCl 4 , while both the SC root extract and Liv-52 reduced significantly these enzymes activity. Also, the levels of glucose, urea and cholesterol were decreased when compared with intoxicated control. Histopathological examination of intoxicated animals showed dilation, hemorrhage, vacuolization, inflammation and necrosis indicating liver damage, while the animals received SC or Liv-52 that showed less pathological effects or normal liver when compared to animals treated with CCl 4 alone. Biochemical and histological results confirm the hepatoprotective effect of aqueous extract of SC.

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“…This dicoumarin drug extracted from the Chinese herb Wilkstroemia indica was shown to suppress HBsAg in Hep3B cells, an effect mediated by activation of protein kinase C. 22 The same investigators reported a powerful suppression of HBsAg by costunlite and dehydrocostus lactone, two alkaloids from Saussurea lappa Clarks root. 23 However, no clinical studies with these compounds have been reported.…”

Section: Studies Of Defined Formulations Of Herbal Medicinesmentioning

confidence: 99%