Active pharmaceutical ingredient-ionic liquids assisted follicular co-delivery of ferulic acid and finasteride for enhancing targeted anti-alopecia

Xiao, Ting; Li, Bin; Lai, Rongrong; Liu, Ziyi; Xiong, Sha; Li, Xiaojuan; Zeng, Yao; Jiao, Siwen; Tang, Yujia; Lu, Yi; Xu, Yuehong

doi:10.1016/j.ijpharm.2023.123624

International Journal of Pharmaceutics

2023

DOI: 10.1016/j.ijpharm.2023.123624

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Active pharmaceutical ingredient-ionic liquids assisted follicular co-delivery of ferulic acid and finasteride for enhancing targeted anti-alopecia

Ting Xiao,

Bin Li,

Rongrong Lai

et al.

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2024

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Cited by 5 publications

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Potentials of ionic liquids to overcome physical and biological barriers

Beaven,

Kumar,

et al. 2024

Advanced Drug Delivery Reviews

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Potentials of ionic liquids to overcome physical and biological barriers

Beaven,

Kumar,

et al. 2024

Advanced Drug Delivery Reviews

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The molecular design of novel phospholipid-inspired ionic liquid transdermal penetration enhancers: Innovative insights on the action mode and mechanism

Chen,

Liu,

Hong

et al. 2024

International Journal of Pharmaceutics

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Effects of Biomaterials Derived from Germinated Hemp Seeds on Stressed Hair Stem Cells and Immune Cells

Kim,

Kim

2024

IJMS

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Androgenetic alopecia is a genetic disorder that commonly causes progressive hair loss in men, leading to diminished self-esteem. Although cannabinoids extracted from Cannabis sativa are used in hair loss treatments, no study has evaluated the effects of germinated hemp seed extract (GHSE) and exosomes derived from the calli of germinated hemp seeds on alopecia. Therefore, this study aimed to demonstrate their preventive effects against alopecia using various methodologies, including quantitative PCR, flow cytometry, ELISA, and immunocytochemistry. Our research highlights the preventive functions of GHSE (GE2000: 2000 µg/mL) and exosomes from the calli of germinated hemp seeds (E40: 40 μg/mL) in three biochemical categories: genetic modulation in hair follicle dermal papilla stem cells (HFDPSCs), cellular differentiation, and immune system modulation. Upon exposure to dihydrotestosterone (DT), both biomaterials upregulated genes preventing alopecia (Wnt, β-catenin, and TCF) in HFDPSCs and suppressed genes activating alopecia (STAT1, 5α-reductase type 1, IL-15R). Additionally, they suppressed alopecia-related genes (NKG2DL, IL2-Rβ, JAK1, STAT1) in CD8+ T cells. Notably, E40 exhibited more pronounced effects compared to GE2000. Consequently, both E40 and GE2000 effectively mitigated DT-induced stress, activating mechanisms promoting hair formation. Given the limited research on alopecia using these materials, their pharmaceutical development promises significant economic and health benefits.

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Active pharmaceutical ingredient-ionic liquids assisted follicular co-delivery of ferulic acid and finasteride for enhancing targeted anti-alopecia

Cited by 5 publications

References 48 publications

Potentials of ionic liquids to overcome physical and biological barriers

Potentials of ionic liquids to overcome physical and biological barriers

The molecular design of novel phospholipid-inspired ionic liquid transdermal penetration enhancers: Innovative insights on the action mode and mechanism

Effects of Biomaterials Derived from Germinated Hemp Seeds on Stressed Hair Stem Cells and Immune Cells

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