Active Pharmaceutical Ingredients and Aquatic Organisms

Daughton, Christian G.; Brooks, Bryan W.

doi:10.1201/b10598-9

Cited by 26 publications

(21 citation statements)

References 198 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, there has been a growing number of studies addressing effects of human pharmaceuticals on aquatic animals. There are excellent reviews by Kummerer, 2008;Daughton and Brooks, 2011;Boxall et al, 2012;Brausch et al, 2012;Brooks and Huggett, 2012. While there are literally hundreds of human pharmaceuticals excreted and which end up in the aquatic environment, those that are destined to have an effect on the physiology of aquatic invertebrates are ones that would interact with evolutionarily well conserved transporter and receptor proteins. Furthermore, there are model organisms whose physiological systems and their regulation by such proteins are well understood.…”

Section: Antidepressants In the Aquatic Environment A Backgroundmentioning

confidence: 99%

The biological effects of antidepressants on the molluscs and crustaceans: A review

2014

View full text Add to dashboard Cite

Antidepressants are among the most commonly detected human pharmaceuticals in the aquatic environment. Since their mode of action is by modulating the neurotransmitters serotonin, dopamine, and norepinephrine, aquatic invertebrates who possess transporters and receptors sensitive to activation by these pharmaceuticals are potentially affected by them. We review the various types of antidepressants, their occurrence and concentrations in aquatic environments, and the actions of neurohormones modulated by antidepressants in molluscs and crustaceans. Recent studies on the effects of antidepressants on these two important groups show that molluscan reproductive and locomotory systems are affected by antidepressants at environmentally relevant concentrations. In particular, antidepressants affect spawning and larval release in bivalves and disrupt locomotion and reduce fecundity in snails. In crustaceans, antidepressants affect freshwater amphipod activity patterns, marine amphipod photo- and geotactic behavior, crayfish aggression, and daphnid reproduction and development. We note with interest the occurrence of non-monotonic dose responses curves in many studies on effects of antidepressants on aquatic animals, often with effects at low concentrations, but not at higher concentrations, and we suggest future experiments consider testing a broader range of concentrations. Furthermore, we consider invertebrate immune responses, genomic and transcriptomic sequencing of invertebrate genes, and the ever-present and overwhelming question of how contaminant mixtures could affect the action of neurohormones as topics for future study. In addressing the question, if antidepressants affect aquatic invertebrates at concentrations currently found in the environment, there is strong evidence to suggest the answer is yes. Furthermore, the examples highlighted in this review provide compelling evidence that the effects could be quite multifaceted across a variety of biological systems.

show abstract

Section: Antidepressants In the Aquatic Environment A Backgroundmentioning

confidence: 99%

The biological effects of antidepressants on the molluscs and crustaceans: A review

2014

View full text Add to dashboard Cite

show abstract

“…Therefore, the interest in knowing the ecotoxicological effects of PPCPs on the environment has increased in the last years. Some authors (Brausch and Rand, 2011;Cleuvers, 2003Cleuvers, , 2004Daughton and Brooks, 2010;Fent et al, 2006;Sanderson et al, 2004a;Santos et al, 2010;Vasquez and Fatta-Kassinos, 2013) have reported ecotoxicogical data from different types of assays (for single PPCP or their mixtures) including different species (trophic levels), times of exposure (chronic, subchronic or acute) and endpoints (Half maximal effective concentration, EC50; concentration which causes the death of 50% of the sample population, LC50; Non observed adverse effect level, NOAEL; Lowest observed adverse effect level, LOAEL).…”

Section: Introductionmentioning

confidence: 99%

The potential ecotoxicological impact of pharmaceutical and personal care products on humans and freshwater, based on USEtox™ characterization factors. A Spanish case study of toxicity impact scores

García

García‐Encina

Mata

2017

Science of The Total Environment

View full text Add to dashboard Cite

Pharmaceutical and personal care products (PPCPs) are being increasingly included in Life Cycle Assessment studies (LCAs) since they have brought into evidence both human and ecological adverse effects due to their presence in different environmental compartments, wastewater facilities and industry. Therefore, the main goal of this research was to estimate the characterization factors (CFs) of 27 PPCPs widely used worldwide in order to incorporate their values into Life Cycle Impact Assessment studies (LCIA) or to generate a toxicity impact score ranking. Physicochemical properties, degradation rates, bioaccumulation, ecotoxicity and human health effects were collected from experimental data, recognized databases or estimated using EPI Suite™ and the USEtox™ software, and were subsequently used for estimating CFs. In addition, a Spanish toxicity impact score ranking was carried out for 49 PPCPs using the 27 newly calculated CFs, and 22 CFs already available in the literature, besides the data related to the occurrence of PPCPs in the environment in Spain. It has been highlighted that emissions into the continental freshwater compartment showed the highest CFs values for human effects (ranging from 10 to 10Cases·kg), followed by emissions into the air (10 to 10Cases·kg), soil (10 to 10Cases·kg) and seawater (10 to 10Cases·kg). CFs regarding the affectation of freshwater aquatic environments were the highest of those proceeding from emissions into continental freshwater (between 1 to 10PAF·m·day·kg) due to the direct contact between the source of emission and the compartment affected, followed by soil (among 10 to 10PAF·m·day·kg), and air (among 10 to 10PAF·m·day·kg) while the lowest were the CFs of continental seawater (among 10 to 10PAF·m·day·kg). Freshwater aquatic ecotoxicological CFs are much higher than human toxicity CFs, demonstrating that the ecological impact of PPCPs in aquatic environments must be a matter of urgent attention. According to the Spanish toxicity impact score calculated, the PPCPs with the highest impact are hormones, antidepressants, fragrances, antibiotics, angiotensin receptor blockers and blood lipid regulators, which have already been found in other kinds of score rankings. These results, which were not available until now, will be useful in order to perform better LCIA studies, incorporating the micro-pollutants whose CFs have been estimated, or in order to carry out single hazard/risk environmental impact assessments.

show abstract

“…Whether this difference increased microbial biotransformation of pharmaceuticals (Eggen and Vogelsang, 2015) in the Paraná river is not known. It is also important to note that, aquatic bioavailability of ionizable contaminants, including the weakly basic pharmaceuticals examined in the present study, is influenced by surface water pH and the dissociation constant (pKa) of each compound (Daughton and Brooks 2011). In our study, surface water of the Acaraguá river was more neutral (pH=7.3) while a slightly alkaline environment was found in the Paraná (pH=8.4, Table 1).…”

Section: Water Quality Parametersmentioning

confidence: 54%

“…Globally, ~80% of sewage production is released to the environment untreated (WWAP 2017). These facts raise concern about the potential for bioaccumulation and associated adverse effects to aquatic wildlife (Daughton and Brooks, 2011), which was previously identified as a key research need to define risks of pharmaceuticals in the environment (Boxall et al, 2012;Rudd et al, 2014). Unfortunately, few studies have been focused…”

Section: Introductionmentioning

confidence: 99%

Pharmaceuticals, illicit drugs and their metabolites in fish from Argentina: Implications for protected areas influenced by urbanization

Ondarza

Haddad

Avigliano

et al. 2019

Science of The Total Environment

Self Cite

103

View full text Add to dashboard Cite

Active Pharmaceutical Ingredients and Aquatic Organisms

Cited by 26 publications

References 198 publications

The biological effects of antidepressants on the molluscs and crustaceans: A review

The biological effects of antidepressants on the molluscs and crustaceans: A review

The potential ecotoxicological impact of pharmaceutical and personal care products on humans and freshwater, based on USEtox™ characterization factors. A Spanish case study of toxicity impact scores

Pharmaceuticals, illicit drugs and their metabolites in fish from Argentina: Implications for protected areas influenced by urbanization

Contact Info

Product

Resources

About