Active secretion of IL-33 from astrocytes is dependent on TMED10 and promotes central nervous system homeostasis

Jiao, Mengya; Wang, Chenchen; Tang, Xuhuan; Dai, Chan; Zhang, Na; Fan, Anqi; Qian, Zhigang; Liu, Shiwang; Zhang, Feng; Li, Bin; Xu, Yong; Tan, Zheng; Gong, Feili; Lu, Yisheng; Zheng, Fang

doi:10.1016/j.bbi.2024.04.028

Brain, Behavior, and Immunity

2024

DOI: 10.1016/j.bbi.2024.04.028

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Active secretion of IL-33 from astrocytes is dependent on TMED10 and promotes central nervous system homeostasis

Mengya Jiao,

Chenchen Wang,

Xuhuan Tang

et al.

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Cited by 3 publications

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IL-33 in Ischemic Stroke: Brain vs. Periphery

Mathias,

Machado,

Tiscoski

et al. 2024

Inflammation

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IL-33 in Ischemic Stroke: Brain vs. Periphery

Mathias,

Machado,

Tiscoski

et al. 2024

Inflammation

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The IL-33/ST2 Axis Protects Retinal Ganglion Cells by Modulating the Astrocyte Response After Optic Nerve Injury

Qian,

Jiao,

Zhang

et al. 2024

Neurosci. Bull.

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The endolysosomal system in conventional and unconventional protein secretion

Néel,

Chiritoiu-Butnaru,

Fargues

et al. 2024

Journal of Cell Biology

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Most secreted proteins are transported through the “conventional” endoplasmic reticulum–Golgi apparatus exocytic route for their delivery to the cell surface and release into the extracellular space. Nonetheless, formative discoveries have underscored the existence of alternative or “unconventional” secretory routes, which play a crucial role in exporting a diverse array of cytosolic proteins outside the cell in response to intrinsic demands, external cues, and environmental changes. In this context, lysosomes emerge as dynamic organelles positioned at the crossroads of multiple intracellular trafficking pathways, endowed with the capacity to fuse with the plasma membrane and recognized for their key role in both conventional and unconventional protein secretion. The recent recognition of lysosomal transport and exocytosis in the unconventional secretion of cargo proteins provides new and promising insights into our understanding of numerous physiological processes.

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Active secretion of IL-33 from astrocytes is dependent on TMED10 and promotes central nervous system homeostasis

Cited by 3 publications

References 68 publications

IL-33 in Ischemic Stroke: Brain vs. Periphery

IL-33 in Ischemic Stroke: Brain vs. Periphery

The IL-33/ST2 Axis Protects Retinal Ganglion Cells by Modulating the Astrocyte Response After Optic Nerve Injury

The endolysosomal system in conventional and unconventional protein secretion

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