Active smoking and a history of smoking are associated with enhanced prostaglandin F2α, interleukin-6 and F2-isoprostane formation in elderly men

Helmersson, Johanna; Larsson, Anders; Vessby, Bengt; Basu, Samar

doi:10.1016/j.atherosclerosis.2004.11.026

Cited by 156 publications

(138 citation statements)

References 33 publications

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“…Our data support previous findings that certain biomarkers are increased with cigarette smoke exposure, specifically, CRP, fibrinogen, 42 ICAM-1, 11 IL-6, 9 urinary isoprostanes, 43 and Pselectin. 17 The pattern of marker elevation did not localize to a particular inflammatory pathway thereby confirming the complexity of biochemical events that occur in smokers.…”

Section: Resultssupporting

confidence: 91%

Relation of smoking status to a panel of inflammatory markers: The Framingham offspring

et al. 2008

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Aims-We sought to investigate the hypothesis that smoking is accompanied by systemic inflammation.Methods and Results-We examined the relation of smoking to 11 systemic inflammatory markers in Framingham Study participants (n=2944, mean age 60 years, 55% women, 12% ethnic minorities) examined from 1998-2001. The cohort was divided into never (n=1149), former (n=1424), and current smokers with last cigarette >6 hours (n=134) or ≤6 hours (n=237) prior to phlebotomy. In multivariable-adjusted models there were significant overall between-smoking group differences (defined as p<0.0045 to account for multiple testing) for every inflammatory marker tested, except for serum CD40 ligand (CD40L), myeloperoxidase (MPO) and tumor necrosis factor receptor-2 (TNFR2). With multivariable-adjustment, pair-wise comparisons with never smokers revealed that former smokers had significantly lower concentrations of plasma CD40L (p<0.0001) and higher concentrations of C-reactive protein (p=0.002).Conclusions-As opposed to never smokers, those with acute cigarette smoke exposure (≤6 hours) had significantly higher concentrations of all markers (p<0.0001) except serum CD40L, MPO, and TNFR2; plasma CD40L were significantly lower. Compared with never smokers, cigarette smokers have significantly elevated concentrations of most circulating inflammatory markers, consistent with the hypothesis that smoking is associated with a systemic inflammatory state.

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Section: Resultssupporting

confidence: 91%

Relation of smoking status to a panel of inflammatory markers: The Framingham offspring

et al. 2008

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“…Inflammatory changes may increase turnover of micronutrients so that blood concentrations are lower in smokers than non-smokers [57]. Unlike the majority of previous studies such as [58,59], we did not see significantly higher baseline CRP levels among smokers within this study; although a current meta-analysis should confirm the relationship between smoking status and CRP [60], as results have not always been consistent [61]. However, we did show that smokers had significantly higher baseline ADMA levels than non-smokers within this population, which has been previously reported in some [62][63][64], although not all [65,66] studies.…”

Section: Discussioncontrasting

confidence: 94%

Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and C-reactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trial

et al. 2010

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Woodside, J. (2010). Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and Creactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trial. European Journal of Nutrition, 49(8) AbstractPurpose Cardiovascular risk factors such as elevated levels of asymmetric dimethylarginine (ADMA)/C-reactive protein (CRP) and homocysteine are potentially related to essential micronutrients such as certain B vitamins and antioxidant vitamins. The aim of the present study was to investigate whether supplementation with moderate doses of B vitamins and/or antioxidants could alter either ADMA and/or CRP concentrations in middle-aged, apparently healthy men with mildly elevated homocysteine levels. Methods A randomised, double-blind, factorial design, intervention study was carried out on 132 men with mildly elevated homocysteine levels, allocated to four groups (a) B vitamins alone-1 mg folic acid, 7.2 mg pyridoxine, 0.02 mg cyanocobalamin daily, (b) antioxidants alone-150 mg ascorbic acid, 67 mg vitamin E, 9 mg b-carotene daily, (c) B vitamins with antioxidant vitamins, or (d) placebo. A total of 101 men completed the study to 8 weeks.Results When the percentage of baseline ADMA and CRP was examined at 8 weeks, no statistically significant differences were observed between the four groups (p = 0.21 and p = 0.90, respectively). Similar non-significant results were observed when analysis was stratified based on baseline CRP levels (\1.0 mg/L, p = 0.10; C1.0 mg/L, p = 0.64) and smoking status (all p C 0.05). Conclusions Supplementation with moderate doses of B vitamins and/or antioxidants did not alter either ADMA or CRP concentrations in these middle-aged, apparently healthy men with mildly elevated homocysteine levels.

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“…8-epiPGF 2a is an in vivo measurement of oxidative stress and its levels have been reported to be elevated in smokers (48). We found that 8-epiPGF 2a levels were inversely correlated with smoking duration and COHb.…”

Section: Discussionmentioning

confidence: 47%

Relationship between Biomarkers of Cigarette Smoke Exposure and Biomarkers of Inflammation, Oxidative Stress, and Platelet Activation in Adult Cigarette Smokers

Liu

Liang

Frost-Pineda

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Cigarette smoking is a risk factor for several diseases, including cardiovascular disease, chronic obstructive pulmonary disease, and lung cancer, but the role of specific smoke constituents in these diseases has not been clearly established.Methods: The relationships between biomarkers of potential harm (BOPH), associated with inflammation [white blood cell (WBC), high sensitivity C-reactive protein (hs-CRP), fibrinogen, and von Willebrand factor (vWF)], oxidative stress [8-epi-prostaglandin F 2a (8-epiPGF 2a )] and platelet activation [11-dehydro-thromboxin B 2 (11-dehTxB 2 )], and machine-measured tar yields (grouped into four categories), biomarkers of exposure (BOE) to cigarette smoke: nicotine and its five metabolites (nicotine equivalents), 4-methylnitrosamino-1-(3-pyridyl)-1-butanol (total NNAL), carboxyhemoglobin, 1-hydroxypyrene, 3-hydroxypropylmercapturic acid, and monohydroxybutenyl-mercapturic acid, were investigated in 3,585 adult smokers and 1,077 nonsmokers.Results: Overall, adult smokers had higher levels of BOPHs than nonsmokers. Body mass index (BMI), smoking duration, tar category, and some of the BOEs were significant factors in the multiple regression models. Based on the F value, BMI was the highest ranking factor in the models for WBC, hs-CRP, fibrinogen, and 8-epiPGF 2a , respectively, and gender and smoking duration for 11-dehTxB 2 and vWF, respectively.Conclusions: Although several demographic factors and some BOEs were statistically significant in the model, the R 2 values indicate that only up to 22% of the variability can be explained by these factors, reflecting

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Active smoking and a history of smoking are associated with enhanced prostaglandin F2α, interleukin-6 and F2-isoprostane formation in elderly men

Cited by 156 publications

References 33 publications

Relation of smoking status to a panel of inflammatory markers: The Framingham offspring

Relation of smoking status to a panel of inflammatory markers: The Framingham offspring

Effect of supplementation with B vitamins and antioxidants on levels of asymmetric dimethylarginine (ADMA) and C-reactive protein (CRP): a double-blind, randomised, factorial design, placebo-controlled trial

Relationship between Biomarkers of Cigarette Smoke Exposure and Biomarkers of Inflammation, Oxidative Stress, and Platelet Activation in Adult Cigarette Smokers

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