Active vs. sedentary lifestyle from weaning to adulthood and susceptibility to ozone in rats

Abstract

The prevalence of a sedentary (SED) life style combined with calorically rich diets has spurred the rise in childhood obesity, which, in turn, translates to adverse health effects in adulthood. Obesity and lack of active (ACT) lifestyle may increase susceptibility to air pollutants. We housed 22-day-old female Long-Evans rats in a cage without (SED) or with a running wheel (ACT). After 10 wk the rats ran 310 ± 16.3 km. Responses of SED and ACT rats to whole-body O (0, 0.25, 0.5, or 1.0 ppm; 5 h/day for 2 days) was assessed. Glucose tolerance testing (GTT) was performed following the first day of O ACT rats had less body fat and an improved glucose GTT. Ventilatory function (plethysmography) of SED and ACT groups was similarly impaired by O Bronchoalveolar lavage fluid (BALF) was collected after the second O exposure. SED and ACT rats were hyperglycemic following 1.0 ppm O GTT was impaired by O in both groups; however, ACT rats exhibited improved recovery to 0.25 and 1.0 ppm O BALF cell neutrophils and total cells were similarly increased in ACT and SED groups exposed to 1.0 ppm O O-induced increase in eosinophils was exacerbated in SED rats. Chronic exercise from postweaning to adulthood improved some of the metabolic and pulmonary responses to O (GTT and eosinophils) but several other parameters were unaffected. The reduction in O-induced rise in BALF eosinophils in ACT rats suggests a possible link between a SED lifestyle and incidence of asthma-related symptoms from O.

Advanced Role of Neutrophils in Common Respiratory Diseases

“…But the persistent inflammation in respiratory system frequently leads to some adverse diseases such as asthma, COPD, and pulmonary fibrosis. In addition, neutrophils can synergize with lymphocytes and other granulocytes, such as Th2/Th17 and eosinophils, to participate in not only innate but also adaptive immune process and promote airway inflammation [22, 23]. The interaction between neutrophils and other immune cells, endogenous composition, and foreign matter is very complex and being clarified thoroughly.…”

Interaction of Diet and Ozone Exposure on Oxidative Stress Parameters within Specific Brain Regions of Male Brown Norway Rats

“…In either case, the organism’s physiological endpoints (i.e., behavioral, pulmonary, cardiac, metabolism, etc.) are the main focus [18,19]. There are few, if any, studies related to the possible interaction between diet and O 3 , especially on brain neurochemistry.…”

Wireless non-invasive motion tracking of functional behavior

“…In women, sedentary behavior can lead to premature menopause [8]. It can also lead to obesity in children, with negative carry-over effects on their adult health [9]. Studies have found that older adults who exercise regularly will have healthier breathing systems than those who display more sedentary behavior [10].…”