Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.

Yamamoto, Masayuki; Ko, Linda J.; Leonard, Mark; Beug, Hartmut; Orkin, Stuart H.; Engel, James Douglas

doi:10.1101/gad.4.10.1650

Cited by 602 publications

(519 citation statements)

References 72 publications

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“…GATA-2 mRNA was also found in cells differentiating along the erythroid, megakaryocytic and mast cell lineage pathways (Yamamoto et al 1990;Zon et al 1991;Dorfman et al 1992). The unique and indispensable contribution of GATA-2 to these lineages was confirmed by targeted disruption of the mouse GATA-2 gene, wherein it was shown that the GATA-2-null mouse did not develop haematopoietic cells (Tsai et al 1995).…”

Section: Discussionmentioning

confidence: 99%

Differential roles of GATA‐1 and GATA‐2 in growth and differentiation of mast cells

Harigae¹,

Takahashi

Suwabe

et al. 1998

Genes to Cells

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Background: While mast cells have been previously shown to express both GATA-1 and GATA-2 mRNAs, individual functions for these related factors during their course of differentiation within the mast cell lineage have not yet been defined. To address this question, the expression of GATA-1 and GATA-2 mRNAs and proteins were examined in three mouse mast cell progenitor lines as well as in mast cells isolated from both wild-type and GATA-1-deficient mice.

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Section: Discussionmentioning

confidence: 99%

Differential roles of GATA‐1 and GATA‐2 in growth and differentiation of mast cells

Harigae¹,

Takahashi

Suwabe

et al. 1998

Genes to Cells

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“…The conditions for binding and electrophoresis were as described previously (Yamamoto et al 1990). Anti-MafK antibody (Igarashi et al 1995b) and anti-p45 antibody (Igarashi et al 1995a) were incubated with nuclear extracts for 3 h on ice before incubation with the probe.…”

Section: Electrophoretic Gel Mobility Shift Assay (Egmsa)mentioning

confidence: 99%

Mesodermal‐ vs. neuronal‐specific expression of MafK is elicited by different promoters

et al. 1996

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Background: Small members of the Maf family of transcriptional regulatory proteins share similar basic-leucine zipper domains but have no intrinsic ability to activate transcription. One member of the family (MafK) has been shown to mediate both negative and positive regulation: in addition to forming a homodimer which represses transcription, MafK can also form a heterodimer with p45 (the large subunit of erythroid transcription factor NF-E2) to activate transcription.

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“…Random site selection has suggested that additional nonconsensus sequences can bind GATA proteins with high affinity (32,42). Two of the GATA transcription factors (GATA-1 and GATA-3) are expressed in a tissuerestricted fashion and have been shown previously to regulate lineage-specific gene expression in erythroid cells and T lymphocytes, respectively (24,29,33,72,78). Moreover, homozygous disruption of the GATA-1 gene in mice results in a specific block in erythroid development (56,68).…”

mentioning

confidence: 99%

The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells.

Ip¹,

Wilson²,

Heikinheimo³

et al. 1994

Mol. Cell. Biol.

171

104

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The unique contractile phenotype of cardiac myocytes is determined by the expression of a set of cardiac muscle-specific genes. By analogy to other mammalian developmental systems, it is likely that the coordinate expression of cardiac genes is controlled by lineage-specific transcription factors that interact with promoter and enhancer elements in the transcriptional regulatory regions of these genes. Although previous reports have identified several cardiac muscle-specific transcriptional elements, relatively little is known about the lineage-specific transcription factors that regulate these elements. In this report, we demonstrate that the slow/cardiac muscle-specific troponin C (cTnC) enhancer contains a specific binding site for the lineagerestricted zinc finger transcription factor GATA-4. This (7, 10,27,35,48,65,81). Therefore, an understanding of muscle cell development must at some level be based upon elucidating the molecular mechanisms that control lineage-specific gene expression during myogenesis.The recent identification and characterization of the basic helix-loop-helix myogenic transcription factors, including MyoD, myogenin, Myf-5, and MRF-4/herculin/Myf-6, as well as the MEF-2 family of transcription factors has added significantly to our understanding of skeletal myogenesis (8, 9,12,15,18,40,41,43,58,59,76,80). These factors bind to and regulate the expression of many skeletal muscle-specific genes (47,48,64,70). In contrast, relatively little is currently understood about the molecular mechanisms that control cardiac muscle-specific gene expression during mammalian development. Despite the fact that overlapping sets of genes are expressed in the heart and skeletal muscle, several lines of evidence suggest that distinct transcriptional programs may regulate these processes. For example, basic helix-loop-helix myogenic transcription factors are not expressed in developing heart or precardiac mesoderm (49,63,64), and mice contain-* Corresponding author. Mailing address:

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Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.

Cited by 602 publications

References 72 publications

Differential roles of GATA‐1 and GATA‐2 in growth and differentiation of mast cells

Differential roles of GATA‐1 and GATA‐2 in growth and differentiation of mast cells

Mesodermal‐ vs. neuronal‐specific expression of MafK is elicited by different promoters

The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells.

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