Activity based evaluation of a traditional Ayurvedic medicinal plant: Saraca asoca (Roxb.) de Wilde flowers as estrogenic agents using ovariectomized rat model

Swar, Gauri; Shailajan, Sunita; Menon, Sasikumar

doi:10.1016/j.jep.2016.11.038

Cited by 19 publications

(12 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kaempferol promoted primordial follicle activation and cell proliferation through the PI3K/AKT pathway (Santos et al, 2019). In addition, kaempferol could regulate the level of serum estrogen and progesterone, resume the estrous cycle, and increase the weight of uterus in ovariectomized rats, which supported the estrogenic potency of kaempferol (Swar et al, 2017). Rutin could ameliorate ovarian injury in rats through its antioxidative effect (Lins et al, 2017;Nayki et al, 2018) and up-regulate the levels of ovarian steroidogenic enzymes (Hu et al, 2017).…”

Section: Discussionmentioning

confidence: 94%

Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats

et al. 2020

View full text Add to dashboard Cite

Backgrounds: Diminished ovarian reserve (DOR) contributes significantly to female infertility. Bushen Cuyun Recipe (BCR, Tradename Yueliang Yin), a product marketed in China, has shown effects in the treatment of female infertility in clinical practices of traditional Chinese medicine (TCM). In this study, we aimed to investigate the chemical compositions of BCR and its efficacy based on scientific evidence and pharmacological mechanisms in DOR treatments. Methods: The chemical compositions of BCR were determined by the UHPLC-LTQ-Orbitrap MS method. DOR was induced in a rat model by intraperitoneal injection of cyclophosphamide (CTX) 90 mg/kg once. After the CTX treatment for 14 days, rats were intragastrically administrated deionized water, dehydroepiandrosterone (DHEA), or BCR in low, middle, and high doses for 30 days. Ovarian index, ovarian morphology, follicle number, and anti-Müllerian hormone (AMH) in serum were determined to assess the effects of BCR. To investigate possible action mechanisms, network pharmacological analysis was used to predict possible pathways in the effects of BCR on female infertility. In experimental studies, the contents of hormones in the hypothalamic-pituitary-ovarian axis (HPOA, including estradiol (E 2), follicle-stimulating hormone (FSH), and gonadotropinreleasing hormone (GnRH)) and pyroptosis-related proteins, including gasdermin D (GSDMD), caspase-1, and interleukin-18 (IL-18), in ovarian were detected by ELISA, immunofluorescence and Western blot. Results: Chemical studies revealed a total 84 components in BCR, which included 43 flavonoids, 13 triterpenoids, 11 phenolic acids, 8 alkaloids, 1 coumarin, 1 anthraquinone, and 7 other components. After treatments with BCR, the ovarian morphology, ovarian index, estrous cycle, growing follicles and corpus luteum from last ovulation, and serum AMH in DOR rats were significantly improved. Network pharmacological analysis suggested that the NOD-like receptor signaling pathway ranked No. 1 among the mechanisms by which BCR affects female infertility. Experimental results demonstrated

show abstract

Section: Discussionmentioning

confidence: 94%

Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats

et al. 2020

View full text Add to dashboard Cite

show abstract

“…All 23 plants in the YPJ formula possess estrogenic and/or antioxidant activity. Therefore, gallic acid, a phenolic antioxidant compound, and quercetin, luteolin, myricetin, genistein, and coumestrol phytoestrogens were selected as markers for the phytochemical analysis of YPJ [5,[44][45][46]. Phytochemical investigation of the YPJ ethanolic extract by HPLC revealed the presence of flavonoids and phenolic acids as the major constituents.…”

Section: Discussionmentioning

confidence: 99%

Effect of Yakae-Prajamduen-Jamod Traditional Thai Remedy on Cognitive Impairment in an Ovariectomized Mouse Model and Its Mechanism of Action

et al. 2022

View full text Add to dashboard Cite

Cognitive impairment is a neurological symptom caused by reduced estrogen levels in menopausal women. The Thai traditional medicine, Yakae-Prajamduen-Jamod (YPJ), is a formula consisting of 23 medicinal herbs and has long been used to treat menopausal symptoms in Thailand. In the present study, we investigated the effects of YPJ on cognitive deficits and its underlying mechanisms of action in ovariectomized (OVX) mice, an animal model of menopause. OVX mice showed cognitive deficits in the Y-maze, the novel object recognition test, and the Morris water maze. The serum corticosterone (CORT) level was significantly increased in OVX mice. Superoxide dismutase and catalase activities were reduced, while the mRNA expression of IL-1β, IL-6, and TNF-α inflammatory cytokines were up-regulated in the frontal cortex and hippocampus of OVX mice. These alterations were attenuated by daily treatment with either YPJ or 17β-estradiol. HPLC analysis revealed that YPJ contained antioxidant and phytoestrogen constituents including gallic acid, myricetin, quercetin, luteolin, genistein, and coumestrol. These results suggest that YPJ exerts its ameliorative effects on OVX-induced cognitive deficits in part by mitigating HPA axis overactivation, neuroinflammation, and oxidative brain damage. Therefore, YPJ may be a novel alternative therapeutic medicine suitable for the treatment of cognitive deficits during the menopausal transition.

show abstract

“…One week after acclimatization, ovariectomy was made by performing bilateral ovariectomy under general anesthesia with i.p. injection of ketamine hydrochloride (100 mg/kg bw) (Swar et al, 2017).…”

Section: Experimental Designmentioning

confidence: 99%

“…Several plants are employed in various therapeutic formulations either directly or as crude extracts for healing of female reproductive disorders (Swar et al, 2017).…”

mentioning

confidence: 99%

Salvia officinalis mitigates uterus and liver damages induced by an estrogen deficiency in ovariectomized rats

et al. 2020

View full text Add to dashboard Cite

Estrogen, a steroid hormone, is a key regulator of the cellular process, involved in the maintenance of female reproductive function (Utian, 1999), and playing a crucial role in the sexual tract. Thus, the ovarian dysfunction during menopause explains several disturbances due to the reduction or the lack of estrogens. According to Karmakar et al. (2017), the hormonal deficit induces psychological and physiological perturbations affecting the health of menopausal women. This could be attributed to redox status imbalance. In fact, previous studies have shown that menopause is considered as a pro-oxidant factor involved in the development of diseases associated with oxidative stress (

show abstract

Activity based evaluation of a traditional Ayurvedic medicinal plant: Saraca asoca (Roxb.) de Wilde flowers as estrogenic agents using ovariectomized rat model

Cited by 19 publications

References 27 publications

Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats

Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats

Effect of Yakae-Prajamduen-Jamod Traditional Thai Remedy on Cognitive Impairment in an Ovariectomized Mouse Model and Its Mechanism of Action

Salvia officinalis mitigates uterus and liver damages induced by an estrogen deficiency in ovariectomized rats

Contact Info

Product

Resources

About