Activity changes and marked stereotypic behavior precede Aβ pathology in TgCRND8 Alzheimer mice

Ambrée, Oliver; Touma, Chadi; Görtz, Nicole; Keyvani, Kathy; Paulus, Werner; Palme, Rupert; Sachser, Norbert

doi:10.1016/j.neurobiolaging.2005.05.009

Cited by 92 publications

(64 citation statements)

References 73 publications

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“…Transgenic mice did not differ from the wild types with regard to numbers of antenna contacts, indicating that daily activity was not affected by genotype. This result contrasts with previous observations from our own lab showing that transgenic CRND8 mice were more active and showed more stereotypic behavior when they were housed in standard-sized cages (Ambrée et al, 2006;Touma et al, 2004). In line with another recent study conducted in an SNE (Lewejohann et al, 2009), no stereotypic behavior was observed at all within the study period.…”

Section: Resultscontrasting

confidence: 97%

Behavioral phenotyping of a murine model of Alzheimer’s disease in a seminaturalistic environment using RFID tracking

Lewejohann

Hoppmann

Kegel

et al. 2009

Behavior Research Methods

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Neurodegenerative disorders such as Alzheimer's disease (AD) are increasingly threatening public health. Most animal models of AD consist of transgenic mice that are usually housed singly or in unisexual groups in small barren cages. Such restricted environments, however, prevent the mice from showing a variety of speciesspecific behaviors and consequently may constrain comprehensive behavioral phenotyping. On the other hand, allowing the animals to freely organize their lives in a spacious physically and socially enriched environment makes behavioral phenotyping laborious and time consuming. Radio frequency identification (RFID) using a network of antennae and small glass-coated transponders labeling each individual allows for gathering spatiotemporal information about a large number of individuals in parallel. The aim of this project was to use the RFID technique to facilitate the characterization of mice carrying a genetic disposition to develop AD-like pathology and of their wild-type conspecifics in a spacious seminaturalistic environment.

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Section: Resultscontrasting

confidence: 97%

Behavioral phenotyping of a murine model of Alzheimer’s disease in a seminaturalistic environment using RFID tracking

Lewejohann

Hoppmann

Kegel

et al. 2009

Behavior Research Methods

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“…These data indicate that APPSwe/PS1dE9 mice show locomotor hyperactivity, a finding consistent with a number of previous studies (23,(40)(41)(42). This hyperactivity was manifest particularly at night as expected in Figure 4A for illustration).…”

Section: Discussionsupporting

confidence: 92%

Abnormal Clock Gene Expression and Locomotor Activity Rhythms in Two Month-Old Female APPSwe/PS1dE9 Mice

Oyegbami

Collins

Pardon

et al. 2017

CAR

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“…Since the development of amyloid pathology has been associated with hyperactivity and stereotypic behavior in previous studies (Ambrée et al, 2006, Richter et al, 2008, the sensorimotor activity of rats in the experimental area was analyzed during the learning course (during baseline, days 1, 7, 15, and 21). Episodes of rearing for item exploration were defined as the completion of the following exploratory movement pattern: initiation of climbing, climbing, rearing (in which the rat "stands" on its back feet with its forepaws contacting the wall, its body extended and its nose directed toward the stimulus at a maximum distance of 2 cm from it), and descent.…”

Section: Methodsmentioning

confidence: 99%

Decreased Rhythmic GABAergic Septal Activity and Memory-Associated θ Oscillations after Hippocampal Amyloid-β Pathology in the Rat

Villette¹,

Poindessous‐Jazat²,

Simon³

et al. 2010

J. Neurosci.

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The memory deficits associated with Alzheimer's disease result to a great extent from hippocampal network dysfunction. The coordination of this network relies on theta () oscillations generated in the medial septum. Here, we investigated in rats the impact of hippocampal amyloid ␤ (A␤) injections on the physiological and cognitive functions that depend on the septohippocampal system. Hippocampal A␤ injections progressively impaired behavioral performances, the associated hippocampal power, and frequency response in a visuospatial recognition test. These alterations were associated with a specific reduction in the firing of the identified rhythmic bursting GABAergic neurons responsible for the propagation of the rhythm to the hippocampus, but without loss of medial septal neurons. Such results indicate that hippocampal A␤ treatment leads to a specific functional depression of inhibitory projection neurons of the medial septum, resulting in the functional impairment of the temporal network.

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Activity changes and marked stereotypic behavior precede Aβ pathology in TgCRND8 Alzheimer mice

Cited by 92 publications

References 73 publications

Behavioral phenotyping of a murine model of Alzheimer’s disease in a seminaturalistic environment using RFID tracking

Behavioral phenotyping of a murine model of Alzheimer’s disease in a seminaturalistic environment using RFID tracking

Abnormal Clock Gene Expression and Locomotor Activity Rhythms in Two Month-Old Female APPSwe/PS1dE9 Mice

Decreased Rhythmic GABAergic Septal Activity and Memory-Associated θ Oscillations after Hippocampal Amyloid-β Pathology in the Rat

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