Activity changes following sulcal, but not medial, ablation of the prefrontal cortex of the guinea pig

Markowitsch, Hans J.; Guldin, Wolfgang O.; Kessler, Josef; Riess, Rudolf

doi:10.3758/bf03337465

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…Eichenbaum, Clegg, & Feeley, 1983; Shipley & Kolb, 1977). A similar dissociation has been described for the guinea pig (Markowitsch, Guldin, Kessler, & Riess, 1980; Markowitsch & Riess, 1981) and also appears to be true for the hamster (current study; Sapolsky & Eichenbaum, 1980; Shipley & Kolb, 1977). Thus, hamsters with medial frontal removals are impaired at species-typical behaviors such as nest-building and hoarding behavior as well as at the acquisition of a spatial reversal problem (Kolb, 1980).…”

Section: Discussionsupporting

confidence: 88%

Neonatal frontal lesions in hamsters impair species-typical behaviors and reduce brain weight and neocortical thickness.

Kolb¹,

Whishaw²

1985

Behavioral Neuroscience

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Syrian golden hamsters with removals of the medial or ventral subfields of the frontal cortex at 4 days of age were compared behaviorally and neuroanatomically with hamsters with similar removals in adulthood. The behavioral results showed that hamsters with neonatal lesions show little sparing of species-typical behaviors such as hoarding and nest building. Study of the development of animals with early lesions showed that although as young juveniles the operated hamsters did not appear to be different from their littermate controls, as they developed they failed to improve in their performance as their littermates did. As adults these early operates were thus severely impaired relative to their littermates. Nonetheless, under certain environmental conditions it was possible to show that the animals were capable of performing the behaviors nearly as proficiently as normal animals. Thus, in order to thoroughly assess the extent of behavioral sparing following early neonatal lesions, it is necessary to test animals under widely varying stimulus conditions. Finally, when the brains of neonatally operated hamsters were compared with those of animals operated on in adulthood, there were striking differences; although the area of cavity appeared smaller in the neonatal operates, their brains weighed less and the remaining neocortex was thinner.

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Section: Discussionsupporting

confidence: 88%

Neonatal frontal lesions in hamsters impair species-typical behaviors and reduce brain weight and neocortical thickness.

Kolb¹,

Whishaw²

1985

Behavioral Neuroscience

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Behavioural changes following lesions of the orbital prefrontal cortex in male rats

Bruin

Oyen

Poll

1983

Behavioural Brain Research

120

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Efferent connections of dorsal and ventral agranular insular cortex in the hamster, Mesocricetus auratus

1982

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The anterior portion of rodent agranular insular cortex consists of a ventral periallocortical region (AIv) and a dorsal proisocortical region (AId). Each of these two cortical areas has distinct efferent connections, but in certain brain areas their projection fields are partially or wholly overlapping. Bilateral projections to layers I, III and VI of medial frontal cortex originate in the dorsal agranular insular cortex and terminate in the prelimbic, anterior cingulate and medial precentral areas; those originating in ventral agranular insular cortex terminate in the medial orbital, infralimbic and prelimbic areas. The dorsal and ventral regions of the agranular insular cortex project topographically to the ipsilateral cortex bordering the rhinal fissure, which includes the posterior primary olfactory, posterior agranular insular, perirhinal and lateral entorhinal areas. Fibers to these lateral cortical areas were found to travel in a cell-free zone, between cortical layer VI and the claustrum, which corresponds to the extreme capsule. The dorsal and ventral regions send commissural projections to layer I, lamina dissecans and outer layer V, and layer VI of the contralateral homotopical cortex, via the corpus callosum. Projections from the ventral and dorsal regions of the agranular insular cortex to the caudatoputamen are topographically arranged and terminate in finger-like patches. The ventral, but not the dorsal region, projects to the ventral striatum and ventral pallidum. The thalamic projections of the ventral and dorsal regions are largely overlapping, with projections from both to the ipsilateral reticular nucleus and bilaterally to the rhomboid, mediodorsal, gelatinosus and ventromedial nuclei. The heaviest projection is that to the full anteroposterior extent of the medial segment of the mediodorsal nucleus. Brainstem areas receiving projections from the ventral and dorsal regions include the lateral hypothalamus, substantia nigra pars compacta, ventral tegmental area and dorsal raphe nucleus. In addition, the ventral region projects to the periaqueductal gray and the dorsal region projects to the parabrachial and ventral pontine nuclei. These efferent connections largely reciprocate the afferent connections of the ventral and dorsal agranular insular cortex, and provide further support for the concept that these regions are portions of an outer ring of limbic cortex which plays a critical role in the expression of motivated, species-typical behaviors.

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Activity changes following sulcal, but not medial, ablation of the prefrontal cortex of the guinea pig

Cited by 4 publications

References 34 publications

Neonatal frontal lesions in hamsters impair species-typical behaviors and reduce brain weight and neocortical thickness.

Neonatal frontal lesions in hamsters impair species-typical behaviors and reduce brain weight and neocortical thickness.

Behavioural changes following lesions of the orbital prefrontal cortex in male rats

Efferent connections of dorsal and ventral agranular insular cortex in the hamster, Mesocricetus auratus

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