Activity of poly(methacrylic acid)-silver nanoparticles on fluconazole-resistant Candida albicans strains: Synergistic and cytotoxic effects

Falcão, Cecília Maria Cruz; Andrade, Audrey Nunes de; Holanda, Vanderlan Nogueira; Figueiredo, Regina Célia Bressan Queiroz de; Ximenes, Eulália Azevedo; Gomes, Anderson S. L.

doi:10.1111/jam.15542

Cited by 6 publications

(8 citation statements)

References 37 publications

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“…Based on these properties, metal nanoparticles have broad applications in the drug delivery of antimicrobial agents [ 29 , 35 , 36 , 37 ]. The use of metal nanoparticles in combination with amphotericin B (AMB), caspofungin (CAS) and fluconazole (FCZ) may enhance its effectiveness against C. albicans [ 14 , 38 , 39 ]. Metal nanoparticles can play an important role in combating C. albicans strains resistant to antifungal drugs and biofilms formed on mucosa and medical devices [ 14 , 15 ].…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

“…The use of metal nanoparticles in combination with amphotericin B (AMB), caspofungin (CAS) and fluconazole (FCZ) may enhance its effectiveness against C. albicans [ 14 , 38 , 39 ]. Metal nanoparticles can play an important role in combating C. albicans strains resistant to antifungal drugs and biofilms formed on mucosa and medical devices [ 14 , 15 ]. Here, recent studies focused on the use of metal nanoparticles to combat C. albicans infections are highlighted, with a special focus on silver (Ag), gold (Au), and iron (Fe) nanoparticles.…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

“…Falcão et al [ 14 ] developed poly(methacrylic acid)-silver nanoparticles (PMAA-AgNPs) capped with FCZ and evaluated their in vitro effects on C. albicans and mammalian cells. PMAA-AgNPs had a spherical shape, mean diameter of 15 nm, and a Zeta potential of −41.83 mV.…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

“…PMAA-AgNPs and FCZ reportedly exhibited synergistic interactions against C. albicans strains resistant to FCZ, leading to a reduction in MIC values and inhibition of germ tube formation. PMAA-AgNPs were toxic in a dose-dependent manner to J774.A1 macrophages and fibroblasts, but the concentrations required to decrease cell viability were higher than those that inhibited C. albicans growth [ 14 ]. This combination therapy provided a convincing way to reduce the amount of antifungal drugs compared to antifungal monotherapy, and most importantly, overcome antifungal drug resistance in C. albicans [ 25 , 50 ].…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

“…C. albicans forms biofilms under different environmental conditions, and on biotic and abiotic surfaces that include host tissues, medical devices, dentures, and catheters [ 14 , 15 ]. Biofilms are communities of yeast, pseudohyphae, and hyphae that are encapsulated in a self-secreted polymeric extracellular matrix [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Metal Nanoparticles to Combat Candida albicans Infections: An Update

et al. 2023

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Candidiasis is an opportunistic mycosis with high annual incidence worldwide. In these infections, Candida albicans is the chief pathogen owing to its multiple virulence factors. C. albicans infections are usually treated with azoles, polyenes and echinocandins. However, these antifungals may have limitations regarding toxicity, relapse of infections, high cost, and emergence of antifungal resistance. Thus, the development of nanocarrier systems, such as metal nanoparticles, has been widely investigated. Metal nanoparticles are particulate dispersions or solid particles 10–100 nm in size, with unique physical and chemical properties that make them useful in biomedical applications. In this review, we focus on the activity of silver, gold, and iron nanoparticles against C. albicans. We discuss the use of metal nanoparticles as delivery vehicles for antifungal drugs or natural compounds to increase their biocompatibility and effectiveness. Promisingly, most of these nanoparticles exhibit potential antifungal activity through multi-target mechanisms in C. albicans cells and biofilms, which can minimize the emergence of antifungal resistance. The cytotoxicity of metal nanoparticles is a concern, and adjustments in synthesis approaches or coating techniques have been addressed to overcome these limitations, with great emphasis on green synthesis.

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Section: Metal Nanoparticlesmentioning

confidence: 99%

Section: Metal Nanoparticlesmentioning

confidence: 99%

Section: Metal Nanoparticlesmentioning

confidence: 99%

Section: Metal Nanoparticlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metal Nanoparticles to Combat Candida albicans Infections: An Update

et al. 2023

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Atividade antifúngica da madeira de Pinus elliottii tratada com nanopartículas de prata

Ferreira,

Tamashiro,

Paiva

et al. 2024

FAAP

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A madeira é um material versátil e sustentável que tem ampla utilização na construção civil, cumprindo funções estruturais e de acabamento. No entanto, é suscetível ao crescimento de fungos filamentosos, incluindo bolores. Este estudo avalia a eficácia das nanopartículas de prata no combate ao Aspergillus niger, uma cepa fúngica comum na madeira de Pinus elliottii. Amostras padronizadas de madeira esterilizados foram tratados com concentrações variadas de nanopartículas de prata para avaliar sua atividade antifúngica. Tanto as amostras tratadas como as não tratadas foram inoculadas com Aspergillus niger para promover a formação de biofilme. As unidades formadoras de colônias presentes no biofilme aderido de cada amostra foram quantificadas e a atividade metabólica foi avaliada. Os resultados demonstraram que todas as amostras de madeira tratadas com nanopartículas de prata inibiram efetivamente o crescimento do biofilme e a atividade metabólica de Aspergillus niger. Consequentemente, pode-se concluir que o tratamento da madeira com nanopartículas de prata inibe efetivamente o crescimento do biofilme e a atividade metabólica do Aspergillus niger. Este tratamento inovador tem um potencial significativo para melhorar a qualidade e durabilidade das estruturas de madeira na construção. Além disso, a prevenção da formação de mofo contribui para melhorar a qualidade de vida dos moradores e do meio ambiente, pois reduz a necessidade de produtos de limpeza e minimiza a necessidade de reformas prediais que geram resíduos em aterros sanitários.

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Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives

Kaur

Kaur²,

Alyami

et al. 2023

Antibiotics

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The nature of microorganisms and the efficiency of antimicrobials have witnessed a huge co-dependent change in their dynamics over the last few decades. On the other side, metals and metallic compounds have gained popularity owing to their effectiveness against various microbial strains. A structured search of both research and review papers was conducted via different electronic databases, such as PubMed, Bentham, Springer, and Science Direct, among others, for the present review. Along with these, marketed products, patents, and Clinicaltrials.gov were also referred to for our review. Different microbes such as bacteria, fungi, etc., and their diverse species and strains have been reviewed and found to be sensitive to metal-carrying formulations. The products are observed to restrict growth, multiplication, and biofilm formation effectively and adequately. Silver has an apt use in this area of treatment and recovery, and other metals like copper, gold, iron, and gallium have also been observed to generate antimicrobial activity. The present review identified membrane disruption, oxidative stress, and interaction with proteins and enzymes to be the primary microbicidal processes. Elaborating the action, nanoparticles and nanosystems are shown to work in our favor in well excelled and rational ways.

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Activity of poly(methacrylic acid)-silver nanoparticles on fluconazole-resistant Candida albicans strains: Synergistic and cytotoxic effects

Cited by 6 publications

References 37 publications

Metal Nanoparticles to Combat Candida albicans Infections: An Update

Metal Nanoparticles to Combat Candida albicans Infections: An Update

Atividade antifúngica da madeira de Pinus elliottii tratada com nanopartículas de prata

Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives

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