Actual memory as a mediator of the amyloid‐subjective cognitive decline relationship

Chen, Xi; Farrell, Michelle E.; Moore, William; Park, Denise C.

doi:10.1016/j.dadm.2018.12.007

Cited by 18 publications

(21 citation statements)

References 44 publications

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“…SCD was assessed in the DLBS using the Metamemory in Adulthood questionnaire (Chen, Farrell, Moore, & Park, 2019), however, this data has yet to be released. SCD was assessed in the DLBS using the Metamemory in Adulthood questionnaire (Chen, Farrell, Moore, & Park, 2019), however, this data has yet to be released.…”

Section: Discussionmentioning

confidence: 99%

“…A potential limitation to this study is that we were unable to control for SCD. SCD was assessed in the DLBS using the Metamemory in Adulthood questionnaire (Chen, Farrell, Moore, & Park, 2019), however, this data has yet to be released. SCD has been related to mesiotemporal atrophy, functional connectivity alterations, decreased task-directed attention, and increased white matter hyperintensities (Fan et al, 2018;Hayes et al, 2017;Van Rooden et al, 2018;Verfaillie et al, 2018;Viviano et al, 2019), and might thus have been an interesting variable to relate to neocortical and hippocampal measures in the newly proposed gradient space.…”

Section: Discussionmentioning

confidence: 99%

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Targeting age‐related differences in brain and cognition with multimodal imaging and connectome topography profiling

Lowe

Paquola

Wael

et al. 2019

Human Brain Mapping

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Aging is characterized by accumulation of structural and metabolic changes in the brain. Recent studies suggest transmodal brain networks are especially sensitive to aging, which, we hypothesize, may be due to their apical position in the cortical hierarchy. Studying an open-access healthy cohort (n = 102, age range = 30-89 years) with MRI and Aβ PET data, we estimated age-related cortical thinning, hippocampal atrophy and Aβ deposition. In addition to carrying out surface-based morphological and metabolic mapping experiments, we stratified effects along neocortical and hippocampal resting-state functional connectome gradients derived from independent datasets. The cortical gradient depicts an axis of functional differentiation from sensory-motor regions to transmodal regions, whereas the hippocampal gradient recapitulates its long-axis. While age-related thinning and increased Aβ deposition occurred across the entire cortical topography, increased Aβ deposition was especially pronounced toward higher-order transmodal regions. Age-related atrophy was greater toward the posterior end of the hippocampal long-axis. No significant effect of age on Aβ deposition in the hippocampus was observed. Imaging markers correlated with behavioral measures of fluid intelligence and episodic memory in a topography-specific manner, confirmed using both univariate as well as multivariate analyses. Our results strengthen existing evidence of structural and metabolic change in the aging brain and support the use of connectivity gradients as a compact framework to analyze and conceptualize brain-based biomarkers of aging.aging, amyloid, atrophy, cognition, hippocampus, neocortex Alexander J. Lowe and Casey Paquola authors are contributed equally to this work.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Targeting age‐related differences in brain and cognition with multimodal imaging and connectome topography profiling

Lowe

Paquola

Wael

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Several studies have shown that worried individuals with SCD have an increased risk of developing objective cognitive decline [6,28,29,77]. However, Chen, et al [62] recently showed that individuals with amyloid plaques, self-reported memory difficulties or memory concerns and not depression or anxiety, were associated with self-awareness of actual worsening in memory function [62]. In our sample, memory was the most frequent SCD complaint, regardless of help-seeking status.…”

Section: Discussionmentioning

confidence: 50%

“…As most SCD cases are benign, or not caused by degenerative brain disease [17], it has been suggested that SCD may be associated with depression, rather than preclinical AD [58,59]. While it has been reported that presentation of SCD may correlate with depression rather than objective cognitive decline [60,61], the link between SCD and depressive symptoms has not been universally supported [62,63].…”

Section: Discussionmentioning

confidence: 99%

Amyloid Plaques and Symptoms of Depression Links to Medical Help-Seeking due to Subjective Cognitive Decline

Espenes

Kirsebom

Eriksson

et al. 2020

JAD

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Background: Subjective cognitive decline (SCD) is associated with an increased risk of Alzheimer's disease (AD). However, patients reporting SCD to their general practitioner are not always referred to a memory clinic. Objective: To investigate whether prior history of medical help-seeking is associated with AD biomarker abnormality, worse cognitive performance, and/or depressive symptoms in SCD. Methods: We compared levels of cerebrospinal fluid (CSF) A␤ 1-42 , cognitive performance, and depressive symptoms (15item Geriatric Depression Scale, GDS-15) between healthy controls (n = 88), SCD with a history of medical help seeking (SCD-HS, n = 67), and SCD non help-seekers (SCD-NHS, n = 44). Cases with evidence of amyloid plaques (CSF A␤ 1-42 ≤708 ng/l) and symptoms of depression (GDS-15≥6) were determined in both SCD groups. Results: The SCD-HS group had lower CSF A␤ 1-42 (p < 0.01), lower word list learning and memory recall (p < 0.0001), and an increased level of depressive symptoms (p < 0.0001) compared to controls and SCD-NHS cases. The SCD-HS group had more cases with symptoms of depression (n = 12, 18%) and amyloid plaques (n = 18, 27%) compared to SCD-NHS (n = 1, 2% and n = 7, 16%, respectively). None of the SCD-HS cases and only one SCD-NHS case had concurrent symptoms of depression and amyloid plaques. The SCD-HS cases showed equal word list learning and memory performance regardless of amyloid status or symptoms of depression. Conclusion: Medical help-seeking in SCD is associated with an increased risk of AD pathology or symptoms of depression. However, subtle memory deficits are seen in SCD help-seekers, also without amyloid plaques or symptoms of depression.

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“…A potential limitation to this study is that we were unable to control for subjective cognitive decline (SCD). SCD was assessed in the DLBS using the Metamemory in Adulthood questionnaire (Chen, Farrell, Moore, & Park, 2019), however, this data has yet to be released. SCD has been related to mesiotemporal atrophy and functional connectivity changes (Fan et al, 2018;Verfaillie et al, 2018), and might thus have been an interesting variable to relate to neocortical and hippocampal measures in the newly proposed gradient space.…”

Section: Discussionmentioning

confidence: 99%

Targeting Age-Related Differences in Brain and Cognition with Multimodal Imaging and Connectome Topography Profiling

Lowe

Paquola

Wael

et al. 2019

Preprint

View full text Add to dashboard Cite

Aging is characterized by accumulation of structural and metabolic changes in the brain. Recent studies suggest transmodal brain networks are especially sensitive to aging, which, we hypothesize, may be due to their apical position in the cortical hierarchy. Studying an open‐access healthy cohort (n = 102, age range = 30–89 years) with MRI and Aβ PET data, we estimated age‐related cortical thinning, hippocampal atrophy and Aβ deposition. In addition to carrying out surface‐based morphological and metabolic mapping experiments, we stratified effects along neocortical and hippocampal resting‐state functional connectome gradients derived from independent datasets. The cortical gradient depicts an axis of functional differentiation from sensory‐motor regions to transmodal regions, whereas the hippocampal gradient recapitulates its long‐axis. While age‐related thinning and increased Aβ deposition occurred across the entire cortical topography, increased Aβ deposition was especially pronounced toward higher‐order transmodal regions. Age‐related atrophy was greater toward the posterior end of the hippocampal long‐axis. No significant effect of age on Aβ deposition in the hippocampus was observed. Imaging markers correlated with behavioral measures of fluid intelligence and episodic memory in a topography‐specific manner, confirmed using both univariate as well as multivariate analyses. Our results strengthen existing evidence of structural and metabolic change in the aging brain and support the use of connectivity gradients as a compact framework to analyze and conceptualize brain‐based biomarkers of aging.

show abstract

Actual memory as a mediator of the amyloid‐subjective cognitive decline relationship

Cited by 18 publications

References 44 publications

Targeting age‐related differences in brain and cognition with multimodal imaging and connectome topography profiling

Targeting age‐related differences in brain and cognition with multimodal imaging and connectome topography profiling

Amyloid Plaques and Symptoms of Depression Links to Medical Help-Seeking due to Subjective Cognitive Decline

Targeting Age-Related Differences in Brain and Cognition with Multimodal Imaging and Connectome Topography Profiling

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