Actualizaciones Sobre "Irisina" La Nueva Mioquina

G, Luz María Trujillo; L, Daniela García; G, Astrid von Oetinger

doi:10.4067/s0717-75182016000300012

Cited by 2 publications

(3 citation statements)

References 52 publications

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“…However, in contrast to this, one of the studies used in this systematic review showed a significant reduction in the values of weight and abdominal fat within the HIIT group and T2D, but it did not show changes in any of the inflammatory biomarkers [ 54 ], and another study showed a significant increase in irisin within the HIIT group, but not in the values of body composition [ 53 ]. The results of the latter study are interesting, as irisin is in charge of converting white fat to brown fat [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have proved the close relationship existing between irisin, T2D and obesity. There are low concentrations of this biomarker in patients with T2D, showing a positive relationship between this biomarker and BMI, insulin sensitivity and weight loss, so this could play a key role in glucose intolerance existing in T2D [ 33 ]. Concerning the adipokines, the function of both leptin and resistin is pro-inflammatory, they take part in the immune response, activate macrophages and lymphocytes [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of High-Intensity Interval Training on Inflammatory Biomarkers in Patients with Type 2 Diabetes. A Systematic Review

Leiva-Valderrama

Montes-de-Oca-Garcia

Opazo-Díaz

et al. 2021

IJERPH

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Background: Due to the prevalence and incidence worldwide of type 2 diabetes, and the significant role physical activity plays in these patients, a systematic review has been conducted to find out the effects that high-intensity interval training has on inflammatory biomarkers in subjects with type 2 diabetes. This project aims to determine the effect this training modality has on inflammatory biomarkers, in addition to observing its effects on the values of body composition and determining if this is a more effective, less effective or equally effective alternative to standard aerobic or resistance training. Methods: A search was conducted in the months of November and December 2020 on different databases: Pubmed, WoS and PEDro. A protocol for this systematic review was registered in PROSPERO (Registration number: CRD42021281186). The studies selected met the previously defined inclusion criteria, and the methodological quality of the papers used was evaluated according to the Downs and Black Checklist. Results: Out of 46 studies found, seven were included. The most relevant data concerning the characteristics of the clinical trials and HIIT characteristics, the values of body composition and the biomarkers under study were extracted from each study. Moreover, the results obtained from the different studies were described. Conclusions: HIIT could have an effect on inflammatory biomarkers. There is likely to be a relationship between changes in inflammatory profile and fat loss. A controlled diet may be a good complement to reduce the inflammatory profile. Further studies are required to determine whether HIIT is a better, worse or an equivalent alternative to medium-intensity aerobic exercise to improve the inflammatory profile.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of High-Intensity Interval Training on Inflammatory Biomarkers in Patients with Type 2 Diabetes. A Systematic Review

Leiva-Valderrama

Montes-de-Oca-Garcia

Opazo-Díaz

et al. 2021

IJERPH

View full text Add to dashboard Cite

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“…En 2012, Boström y colaboradores (3) descubrieron una nueva mioquina, la irisina, una hormona polipeptídica secretada por el músculo a la sangre que activa la función termogénica en los tejidos adiposos, lo que genera efectos en el pardeamiento de ciertos tejidos adiposos blancos (TAB). Se forma como producto de la fibronectina tipo III teniendo en su dominio la proteína 5 (FNDC5), y es inducida por el receptor activado por proliferador de peroxisomas γ (PPARγ) y el coactivador transcripcional 1 a (PGC-1α) en el músculo esquelético (4). Esta pasa a la circulación y actúa sobre los preadipocitos específicos dentro del TAB (que responderían a estímulos para UCP1, a diferencia de los que quedan blancos, sin posibilidad de responder), modifica su desarrollo y pardiza las células al activar la programación celular para desarrollar su capacidad termogénica (5).…”

Section: Introductionunclassified

¿es La Irisina Un Indicador Temprano De Diabetes Mellitus?

Gregori

2024

RAM

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La irisina es una hormona polipeptídica secretada por el músculo que activa la función termogénica en los tejidos adiposos. Su pardeamiento genera efectos que pueden afectar la homeostasis de la glucosa. Se realizó una revisión bibliográfica de estudios donde se midieron los niveles de irisina en sangre por ELISA en pacientes con prediabetes, diabetes mellitus u obesidad. Los términos clave fueron: “(irisin) AND (diabetes)”. La búsqueda se realizó en Pubmed, Lilacs yEpistemonikos. Se incluyeron 21 artículos. Los resultados obtenidos son dispares. No existe un valor de referencia de irisina estadificado como normal. Los datos de las investigaciones no se pudieron comparar entre sí. En los diabéticos tipo 2, el 80% obtuvo valores bajos en comparación con la población sana. No se consideran relevantes las conclusiones de los demás grupos. No es posible considerar esta hormona como predictora de diabetes. Se necesitan más estudios para evaluar esta función.Palabras clave. Irisina, músculo esquelético, prediabetes, diabetes, obesidad.

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Actualizaciones Sobre "Irisina" La Nueva Mioquina

Abstract: ABSTRACT

Cited by 2 publications

References 52 publications

Effects of High-Intensity Interval Training on Inflammatory Biomarkers in Patients with Type 2 Diabetes. A Systematic Review

Effects of High-Intensity Interval Training on Inflammatory Biomarkers in Patients with Type 2 Diabetes. A Systematic Review

¿es La Irisina Un Indicador Temprano De Diabetes Mellitus?

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