Acute Abdomen: An Unusual Presentation of Disseminated Penicillium Marneffei Infection

George, IA; Sudarsanam, TD; Pulimood, AB; Mathews, MS

doi:10.1016/s0255-0857(21)01940-x

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…[4] Inside the immuno-compromised human body, it has been found to reside in fluid-filled or unfilled body cavities like the esophagus, bone marrow, abscesses, axial skeleton, and chylous ascites (a rare condition in which milky white lymphatic fluid known as chyle starts accumulating in the abdominal cavity). [5][6][7] This pathogenic fungus has been reported to cause Penicillosis, spreading throughout the body via the lymphatic system to the skin, liver, reticuloendothelial, digestive, and respiratory systems. Hence, the symptoms of P. marneffei are night sweats, chills, low or high-grade fever, skin lesions, fatigue, chest pain, shortness of breath, abdominal pain, hepatosplenomegaly, and lymphadenopathy in the neck particularly.…”

Section: Introductionmentioning

confidence: 99%

Penicillium marneffei infection involving liver

Afridi

Fatima

2023

DCC

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Penicillium marneffei (P. marneffei) is a pathogenic fungus that can cause fatal infections in humans, particularly immunocompromised hosts. It is prevalent only in the Southeast Asian region. A 5-year-old boy was presented with diagnosed Acute Lymphoblastic Leukemia undergoing chemotherapy and suffering from high-grade fever for 15 days positively responded to antibiotics on the initial day, but later he became unresponsive. He was found negative for blood cultures of bacterial growth. Ultrasound of the abdomen showed a borderline enlarged liver with multiple small hypoechoic areas of variable sizes seen scattered in both lobes of the liver. Morphological and microscopic analyses of liver tissues showed multiple septate hyphae of P. marneffei. Amphotericin B was found to be effective in treating the child. Appropriate identification is essential to treat the pathogen-causing disease, especially in immuno-compromised conditions like a leukemic patient, and determine underlying mechanisms behind the pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Penicillium marneffei infection involving liver

Afridi

Fatima

2023

DCC

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Epidemiology of Talaromycosis (Penicilliosis) Marneffei in India: An Update

Gugnani

Sood

2020

EJMED

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Talaromycosis marneffei (Penicilliosis marneffei) caused by a thermally dimorphic fungus, Talaromyces (Penicillium) marneffei is emerging as an important systemic opportunistic mycosis in HIV infected patients in several countries in Southeast Asia and in northeast India. This study presents an update on epidemiological and clinical aspects of talaromycosis marneffiei in India. A thorough search of literature was done in Medline, PubMed, and Google Scholar, for accessing relevant data. Fifty-three cases of this disease have originated from the Manipur State. Several cases have been reported from Assam, a few are also known from Meghalaya, Mizoram, Nagaland, Sikkim, Delhi and Maharashtra. Clinical manifestations of disseminated infection in AIDS patients are fever, anemia, weight loss, weakness, lymphadenopathy, hepatosplenomegaly, respiratory signs, and characteristic skin lesions. The bamboo rat (Cannomys badius) has been found to be a natural host of Talaromyces (Penicillium) marneffei in Manipur. It is noteworthy that one of the ten T. marneffei isolates from bamboo rats shared the genotype with a human isolate from that area providing evidence for common source of infection for the rats and humans and host to host transmission. Natural reservoir of T. marneffei has not been established, though it has been demonstrated that the fungus can survive in sterile soil for several weeks, but only for a few days in unsterile soil. There is need for comprehensive investigation of T. marneffei infection in humans, and for occurrence of the fungus in bamboo rats and in soils of the rat burrows in India employing conventional and molecular techniques.

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Acute Abdomen: An Unusual Presentation of Disseminated Penicillium Marneffei Infection

Cited by 2 publications

References 5 publications

Penicillium marneffei infection involving liver

Penicillium marneffei infection involving liver

Epidemiology of Talaromycosis (Penicilliosis) Marneffei in India: An Update

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