Acute Anaerobic Exercise Affects the Secretion of Asprosin, Irisin, and Other Cytokines – A Comparison Between Sexes

Abstract

Objective: The new adipokine, which is asprosin, affects glucose release from the liver to the blood, and thus, influences exercise metabolism. This is the first study assessing whether single anaerobic exercise affects asprosin secretion in women and men.Methods: 10 men and 10 women (aged 21.64 ± 1.22 and 22.64 ± 1.49, respectively) performed a single 20-s bicycle sprint. Blood samples were collected before exercise and in the 3′, 15′, 30′, and 60′ of recovery, and 24 h after competition.Results: Only in women did asprosin (P = 0.001) (15′, 30′, 60′, and 24 h after exercise) and irisin (P < 0.001) (15′, 30′, and 60′) concentrations increase. Leptin, however, decreased (P = 0.001) at 3′, 15′, and 30′ in women. There was an increase in interleukin-6 (P < 0.001) at 3′, 15′, 30′, and 60′ of recovery in men, at 15′, 30′, 60′, and 24 h of recovery in women, along with a simultaneous decrease in interleukin-1β (P < 0.001) at 15′, 30′, and 60′ of recovery in men, and at 15′ and 30′ of recovery in women (r = -0.35, P < 0.001). There was a positive correlation between asprosin and adiponectin and a negative one between asprosin and leptin. The increase in irisin concentration at 30′ of recovery was positively correlated with the increase in asprosin concentration and percentage fat content, while being negatively correlated with total and lean body mass (LBM).Conclusion: The single anaerobic effort induced an increase in asprosin and irisin secretion while reducing leptin secretion in women. Adipocytokine concentration changes are inter-related. Regardless of sex, anaerobic efforts induce anti-inflammatory effects.

Increased serum level and impaired response to glucose fluctuation of asprosin is associated with type 2 diabetes mellitus

“…Second, the present study contained only Chinese participants, and the samples were relatively limited; therefore, the present study should be replicated in other ethnicities with larger samples. Third, we could not fully exclude other potential confounding factors, including exercise, as asprosin might be induced by acute anaerobic exercise. In addition, as asprosin was mainly produced by adipose tissue, body percentage of fat mass should also be assessed and adjusted in statistical analyses.…”

Increased serum circulating asprosin levels in children with obesity

“…Some studies have identified asprosin as a biomarker in angina pectoris, as being increased in individuals with glucose dysregulation, as a novel peptide hormone in patients with polycystic ovary syndrome, and related to glucose metabolism and lipid and sex hormone profiles in female patients with metabolic related diseases . Additionally, there have been studies that showed both decreasing and increasing levels of asprosin after exercise . Although some of studies reported conflicting results, it is well established that serum asprosin levels are closely associated with metabolism.…”

Aerobic Exercise Training Decreases Hepatic Asprosin in Diabetic Rats

“…After confirming the fasting glucose levels, the rats were mad to run on a treadmill at 20 m/min for 60 min per day, 4 days per week, for 8 weeks (Eco 3/6 treadmill; Columbus Instruments, Columbus, OH, USA) [16] (Figure 1). On the day after the final aerobic exercise training, all sampling procedures were performed under anesthesia using intraperitoneal injections of alfaxan (25 mg/kg).…”