Acute and chronic cannabinoid extracts administration affects motor function in a CREAE model of multiple sclerosis

Buccellato, Elena; Carretta, Donatella; Utan, Anelì; Cavina, Chiara; Speroni, Ester; Grassi, Gianpaolo; Candeletti, Sanzio; Romualdi, Patrizia

doi:10.1016/j.jep.2010.11.035

Cited by 19 publications

(16 citation statements)

References 50 publications

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“…There is also an animal study that supports previous findings which report that chronic, but not acute, Δ 9 -THC-rich extracts are effective in reducing tremor and spasticity [95]. The Bcannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis^(CAMS) study, where 611 of 630 patients were followed, reported 48 %, 40 %, and 33 % recuperation in tremor of patients consuming cannabis extract, Δ 9 -THC, and placebo, respectively; however, the difference in perception of tremor improvement was not statistically significant [96].…”

Section: Cannabinoids and Ms-related Tremorsupporting

confidence: 86%

Cannabinoids and Tremor Induced by Motor-related Disorders: Friend or Foe?

et al. 2015

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Tremor arises from an involuntary, rhythmic muscle contraction/relaxation cycle and is a common disabling symptom of many motor-related diseases such as Parkinson disease, multiple sclerosis, Huntington disease, and forms of ataxia. In the wake of anecdotal, largely uncontrolled, observations claiming the amelioration of some symptoms among cannabis smokers, and the high density of cannabinoid receptors in the areas responsible for motor function, including basal ganglia and cerebellum, many researchers have pursued the question of whether cannabinoid-based compounds could be used therapeutically to alleviate tremor associated with central nervous system diseases. In this review, we focus on possible effects of cannabinoid-based medicines, in particular on Parkinsonian and multiple sclerosis-related tremors and the common probable molecular mechanisms. While, at present, inconclusive results have been obtained, future investigations should extend preclinical studies with different cannabinoids to controlled clinical trials to determine potential benefits in tremor.

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Section: Cannabinoids and Ms-related Tremorsupporting

confidence: 86%

Cannabinoids and Tremor Induced by Motor-related Disorders: Friend or Foe?

et al. 2015

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“…These 2 synthetic forms of THC have also been shown to have analgesic benefit . ‐ There have been other benefits of THC reported also, including antioxidant and neuroprotective, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), MS, ‐ autism, Parkinson's, Tourette's syndrome, Huntington's disease/chorea, depression, posttraumatic stress disorder (PTSD), sickle cell disease pain, traumatic brain injury (TBI), hypothermia, duodenal ulcers, anorexia and cachexia, inflammatory bowel disease, spinal cord injury, antispasmodic, muscle relaxation, and spasticity, antibacterial effects against methicillin‐resistant Staphylococcus aureus (MRSA) strains, anti‐proliferative/pro‐apoptotic against tumor cell lines of multiple organ systems including brain, breast, colon, and blood, psoriasis,…”

Section: The Cannabinoidsmentioning

confidence: 99%

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

2018

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There is accumulating evidence for various therapeutic benefits of cannabis/cannabinoids, especially in the treatment of pain, which may also apply to the treatment of migraine and headache. There is also supporting evidence that cannabis may assist in opioid detoxification and weaning, thus making it a potential weapon in battling the opioid epidemic. Cannabis science is a rapidly evolving medical sector and industry with increasingly regulated production standards. Further research is anticipated to optimize breeding of strain-specific synergistic ratios of cannabinoids, terpenes, and other phytochemicals for predictable user effects, characteristics, and improved symptom and disease-targeted therapies.

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“…MS is an immuno‐mediated demyelinating disease of the CNS, with a variable clinical course and prognosis . MS is associated with a wide range of disease signs and symptoms, including painful muscle spasms, tremor, ataxia, weakness or paralysis, difficulty in speaking, constipation, and bladder and sexual dysfunction that greatly diminish the quality of life of the affected individual .…”

Section: The Role Of Cannabinoids In Neurological Diseasesmentioning

confidence: 99%

The role of cannabinoids and leptin in neurological diseases

Ağar

2015

Acta Neurol Scand

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Cannabinoids exert a neuroprotective influence on some neurological diseases, including Alzheimer's, Parkinson's, Huntington's, multiple sclerosis and epilepsy. Synthetic cannabinoid receptor agonists/antagonists or compounds can provide symptom relief or control the progression of neurological diseases. However, the molecular mechanism and the effectiveness of these agents in controlling the progression of most of these diseases remain unclear. Cannabinoids may exert effects via a number of mechanisms and interactions with neurotransmitters, neurotropic factors and neuropeptides. Leptin is a peptide hormone involved in the regulation of food intake and energy balance via its actions on specific hypothalamic nuclei. Leptin receptors are widely expressed throughout the brain, especially in the hippocampus, basal ganglia, cortex and cerebellum. Leptin has also shown neuroprotective properties in a number of neurological disorders, such as Parkinson's and Alzheimer's. Therefore, cannabinoid and leptin hold therapeutic potential for neurological diseases. Further elucidation of the molecular mechanisms underlying the effects on these agents may lead to the development of new therapeutic strategies for the treatment of neurological disorders.

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Acute and chronic cannabinoid extracts administration affects motor function in a CREAE model of multiple sclerosis

Cited by 19 publications

References 50 publications

Cannabinoids and Tremor Induced by Motor-related Disorders: Friend or Foe?

Cannabinoids and Tremor Induced by Motor-related Disorders: Friend or Foe?

Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science

The role of cannabinoids and leptin in neurological diseases

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