Acute and chronic toxicological studies of Ajuga iva in experimental animals

El-Hilaly, Jaouad; Israili, Zafar H.; Lyoussi, Badiaâ

doi:10.1016/j.jep.2003.11.009

Cited by 348 publications

(234 citation statements)

References 45 publications

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“…These results are comparable to the work [10] in the study of the sub-chronic toxicity of Argemone mexicana. In addition, variation in body weight is used as an indicator of the adverse effects of chemical compounds [11].…”

Section: Effect Of Eear On the Weight Of Wistar Rats And Their Organsmentioning

confidence: 99%

Acute Toxicity Evaluation of Ethanolic Extract of Aristolochia Albida Duch. Leaves on Wistar Rats Liver and Kidney Functions

Guinnin

Klotoé

Atègbo

2017

Int J Pharm Pharm Sci

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Objective: Aristolochia albida Duch is frequently used by alternative medicine to treat some pathologies like hepatitis. Our main objective was to evaluate the acute oral toxicity of the ethanolic extract of this plant.Methods: Exploratory tests for acute oral toxicity are performed in vivo on Wistar albino rats in a limit test of 2000 mg/kg for 14 d in accordance with the OECD Guidelines 423. The clinical signs were observed every day, followed by measurement of body weight change, the haematological and biochemical examinations were executed and statistical analysis was performed. Results:The various clinical signs observed after administration and for 14 d were recorded and no mortality was observed. With the exception of white blood cells, mean cell volume and platelets with statistically significant difference in control (p<0.05), all the haematological parameters showed an insignificant statistical difference to the control ratio (p>0.05). For biochemical parameters, except blood glucose and total protein of control batches, which show a significant statistical difference after 14 d (p>0.05), all the biochemical parameters show the statistically insignificant difference for test and controls batches (p>0.05) as well as the weight variation of the animals. Conclusion:The ethanolic extract of the leaves of A. albida Duch (EEAr) had not toxic effect on the biochemical and hematological parameters studied at a dose of 2000 mg/kg. The lethal dose is therefore over 2000 mg/kg.

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Section: Effect Of Eear On the Weight Of Wistar Rats And Their Organsmentioning

confidence: 99%

Acute Toxicity Evaluation of Ethanolic Extract of Aristolochia Albida Duch. Leaves on Wistar Rats Liver and Kidney Functions

Guinnin

Klotoé

Atègbo

2017

Int J Pharm Pharm Sci

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“…The kidney function parameters such as urea and creatinine did not reveal any significant changes following 28 day oral administration of extract. The lack of significant alterations in the levels of ALT, AST, creatinine, and BUN are good indicators of liver and kidney functions [24], which suggests that sub-chronic administration of G. mollis stem bark extract did not alter the hepatocytes and kidneys of the animals.…”

Section: Discussionmentioning

confidence: 99%

Acute and sub-chronic toxicity evaluations of aqueous extract from stem bark of Grewia mollis (Malvaceae) in rats

Pongri

Igbe

2017

Herba Polonica

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“…The methods described by Hilaly et al [26] and Lorke [27] and modified by Ojewole [28] were used for the acute toxicity study of T. violacea. The acute of physiological saline by means of a bulbed steel needle.…”

Section: Acute Toxicity Studymentioning

confidence: 99%

Investigation of Some Possible Mechanisms Involved in the Anticonvulsant Activity of Tulbaghia violacea Harv

Masoud¹

2017

JPP

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Even though Tulbaghia violacea has been used to treat and manage epilepsy in South Africa by traditional medicine practitioners, no evidence in any literature has shown any scientific scrutiny of the effectiveness of the plant species in therapy. This study was intended, therefore, to investigate the anticonvulsant effect of the leaf methanol extract of Tulbaghia violacea by studying its effect against tonic convulsion induced by either PTZ (pentylenetetrazole), bicuculline, picrotoxin, strychnine or NMDLA (N-methyl-DL-aspartic acid) in mice. Qualitative phytochemical analysis, acute toxicity and HPLC studies were also carried out on the plant species. Leaf methanol extract of Tulbaghia violacea, phenobarbitone, diazepam or muscimol significantly antagonised PTZ, bicuculline or picrotoxin-induced convulsion. Combined treatment of sub-effective doses of T. violacea and muscimol significantly antagonised tonic convulsion induced by PTZ. T. violacea or phenobarbitone significantly antagonised strychnine-induced tonic convulsion. T. violacea or LY233053 significantly antagonised NMDLA-elicited tonic convulsion. Phenytoin or DMSO (dimethylsulfoxide) did not significantly affect the tonic convulsion produced by PTZ, bicuculline, picrotoxin, strychnine or NMDLA. The phytochemical qualitative analysis of the plant species showed the presence of alkaloids, saponins, reducing sugars, flavonoids, cardiac glycosides, triterpene steroids, quinones and tannins. The LD50 value obtained following oral administration of the plant extract was over 4000 mg/kg. The data in the present study indicate that the leaf methanol extract of T. violacea has anticonvulsant activity which is probably underpinned by GABAergic, glutaminergic and glycinergic mechanisms.

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Acute and chronic toxicological studies of Ajuga iva in experimental animals

Cited by 348 publications

References 45 publications

Acute Toxicity Evaluation of Ethanolic Extract of Aristolochia Albida Duch. Leaves on Wistar Rats Liver and Kidney Functions

Acute Toxicity Evaluation of Ethanolic Extract of Aristolochia Albida Duch. Leaves on Wistar Rats Liver and Kidney Functions

Acute and sub-chronic toxicity evaluations of aqueous extract from stem bark of Grewia mollis (Malvaceae) in rats

Investigation of Some Possible Mechanisms Involved in the Anticonvulsant Activity of Tulbaghia violacea Harv

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