Acute and short-term toxicity studies on di-n-butyltin dichloride in rats

n‐Butylzinnverbindungen [MAK Value Documentation in German language, 2008]

“…Zudem trat eine signifikante Verringerung der Körpergewichtsentwicklung auf (Penninks und Seinen 1982;Seinen et al 1977 b). Mäuse zeigten diese DBTC-Wirkungen nicht gehaltes im Serum (Gaunt et al 1968). DBTL führte ab ca.…”

Immune Suppression as Related to Toxicology

“…108 To date, DOTC and DBTC have similar in vitro actions on human and rat thymocytes and, thus, could produce immunosuppression in man. Therefore, it is relevant (as discussed by Seinen et al 56 ) to reconsider the no-effect level (established for DBTC at 40 ppm in diet, but not based on thymus effects) 109 by taking into account the atrophy of the thymus, since this parameter is of functional significance as shown in the function studies.…”

Organotin Compounds: Industrial Applications and Biological Investigation

“…Chronic toxicity studies on di-n-butyltin dichloride in rats were conducted by Gaunt et al (31). The compound was fed to rats for 90 days at dietary levels of 0 (control), 10, 20, 40, and 80 ppm.…”