Acute and sub-chronic toxicities assessment of methanol bark extract of Hypericum roeperianum in rats

Guefack, Michel-Gael F.; Damen, François; Ngaffo, Carine M.N.; Kuete, Victor

doi:10.1016/j.sajb.2022.08.006

Cited by 7 publications

(2 citation statements)

References 28 publications

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“…Hematological and serum biochemical parameters can intuitively reveal whether MRP is toxic to induce hemolysis (Guefack et al, 2022). Our results showed that LDG and MDG of MRP were not significantly different in terms of hematological and serum biochemical parameters (p > 0.05); compared with the control group, the difference of red blood cells in HDG group was significant (p < 0.05).…”

Section: Macroscopic and Histopathological Examinationmentioning

confidence: 61%

Insights into sub-chronic toxicity effects of enzymatic hydrolysate of peony seed meal derived Maillard reaction products in SD rats

et al. 2023

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Despite the use of Maillard reaction products (MRPs) as food flavoring and coloring agents, they are also known to constitute acrylamide, heterocyclic amines, advanced glycosylation end products, and precursors of low molecular weight compounds. The very little is known about the toxicology of peony seed meal-derived MRPs. In this study, sub-chronic toxicity of peony seed meal derived MRPs was evaluated in Sprage-Dawley (SD) rats. Results showed that the body weight, hematology and serum biochemistry, organ coefficient and histopathology of SD rats with daily intake of peony seed meal-derived MRPs lower than 0.45 g/kg were not affected. After feeding with peony seed meal-derived MRPs for 13-weeks, there were no significant toxic effect on either male or female rats. This study provides a theoretical basis for the safety of MRPs derived from the reactants of enzymatic hydrolysis of peony seed meal.

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Section: Macroscopic and Histopathological Examinationmentioning

confidence: 61%

Insights into sub-chronic toxicity effects of enzymatic hydrolysate of peony seed meal derived Maillard reaction products in SD rats

et al. 2023

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“…At both the mid-term (Day 45) and the end of the experiment (Day 90), five rats from each group were euthanized by cervical dislocation for necropsy. The hearts, livers, spleens, lungs, and kidneys of the rats were embedded in paraffin, stained with eosin and hematoxylin, and observed under a microscope to assess the impact of the treatment on their organs ( OECD, 2018 ; Guefack et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Safety and efficacy evaluation of halicin as an effective drug for inhibiting intestinal infections

Zhang,

Lin,

Han

et al. 2024

Front. Pharmacol.

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Halicin, the first antibacterial agent discovered by artificial intelligence, exerts broad-spectrum antibacterial effects and has a unique structure. Our study found that halicin had a good inhibitory effect on clinical isolates of drug-resistant strains and Clostridium perfringens (C. perfringens). The safety of halicin was evaluated by acute oral toxicity, genotoxicity and subchronic toxicity studies. The results of acute toxicity test indicated that halicin, as a low-toxicity compound, had an LD50 of 2018.3 mg/kg. The results of sperm malformation, bone marrow chromosome aberration and cell micronucleus tests showed that halicin had no obvious genotoxicity. However, the results of the 90-day subchronic toxicity test indicated that the test rats exhibited weight loss and slight renal inflammation at a high dose of 201.8 mg/kg. Teratogenicity of zebrafish embryos showed that halicin had no significant teratogenicity. Analysis of intestinal microbiota showed that halicin had a significant effect on the intestinal microbial composition, but caused a faster recovery. Furthermore, drug metabolism experiments showed that halicin was poorly absorbed and quickly eliminated in vivo. Our study found that halicin had a good therapeutic effect on intestinal infection model of C. perfringens. These results show the feasibility of developing oral halicin as a clinical candidate drug for treating intestinal infections.

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Hypericum roeperianum bark extract suppresses breast cancer proliferation via induction of apoptosis, downregulation of PI3K/Akt/mTOR signaling cascade and reversal of EMT

Guefack,

Talukdar,

Mukherjee

et al. 2024

Journal of Ethnopharmacology

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Acute and sub-chronic toxicities assessment of methanol bark extract of Hypericum roeperianum in rats

Cited by 7 publications

References 28 publications

Insights into sub-chronic toxicity effects of enzymatic hydrolysate of peony seed meal derived Maillard reaction products in SD rats

Insights into sub-chronic toxicity effects of enzymatic hydrolysate of peony seed meal derived Maillard reaction products in SD rats

Safety and efficacy evaluation of halicin as an effective drug for inhibiting intestinal infections

Hypericum roeperianum bark extract suppresses breast cancer proliferation via induction of apoptosis, downregulation of PI3K/Akt/mTOR signaling cascade and reversal of EMT

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