Acute and Subacute Toxicity and Cytotoxicity of Opuntia Dillenii (Ker-Gawl) Haw. Seed Oil and Its Impact on the Isolated Rat Diaphragm Glucose Absorption

Boutahiri, Salima; Kharchoufa, Loubna; Mechchate, Hamza; Kamaly, Omkulthom Al; Berraaouan, Ali; Eto, Bruno; Ziyyat, Abderrahim; Mekhfi, Hassane; Legssyer, Abdelkhaleq; Aziz, Mohammed; Bnouham, Mohamed

doi:10.3390/molecules26082172

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…It also discussed the molecular mechanism underlying cytotoxicity, which involves a complex series of events, including cell cycle arrest, the formation of apoptotic bodies, nuclear condensation, exposure to phosphatidylserine, and mitochondrial dysfunction. 17 Another study investigating the protective effects of cactus seed oil on gentamicin-induced renal toxicity demonstrated that the cactus seed oil extract had no significant effect on weight changes in study groups, 11 which conforms to the results of the present study.…”

Section: Discussionsupporting

confidence: 90%

Hepatoprotective Effects of Opuntia dillenii Haw Fruit in a Mice Model of Lung Cancer

Shirazinia,

Sadeghi Hashjin,

Muhammadnejad

2023

Int J Basic Sci Med

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Introduction: Lung cancer is an important burden, causing a massive rate of deaths every year. Using a specialized treatment regimen can improve treatment outcomes and reduce treatment-related adverse events. This study aimed to evaluate the protective effects of the Opuntia dillenii fruit hydroalcoholic extract (ODHAE) in a mouse model of lung cancer. Methods: Eight groups of lung cancer-induced BALB/c mice (each containing twelve animals) were included in this study. They were the control group, groups receiving the ODHAE extract at doses of 50, 100, and 200 mg/kg by oral gavage, the cisplatin group receiving cisplatin intraperitoneal injection, and groups receiving cisplatin and different doses of ODHAE (50, 100, and 200 mg/kg). Weight and tumor changes were evaluated in the short and long phases of the study, including 30 and 90 days, respectively. Liver transaminase and survival time were evaluated in different groups. Malondialdehyde (MDA) was evaluated in different groups as an indicator of lipid peroxidation. Statistical tests were performed using GraphPad Prism 8. Graphs were designed using GraphPad Prism 8 as well. Results: The observed weight changes were not statistically significant across all groups, except for group 8. However, in groups that did not receive cisplatin treatment, there was a significant increase in tumor volume. Conversely, tumor volume change did not reach statistical significance in all groups receiving cisplatin. The administration of ODHAE, along with cisplatin, demonstrated a dose-dependent increase in the survival time among the relevant groups. Furthermore, oral administration of ODHAE exhibited a significant reduction in transaminase levels, serving as a reliable biomarker for assessing the hepatoprotective effect of the ODHAE extract. Additionally, ODHAE displayed a dose-dependent reduction in MDA levels, indicating its potential as a therapeutic agent for mitigating oxidative stress. Conclusion: The administration of ODHAE was not effective in reducing tumor growth but significantly increased survival time and healed the liver injury induced by cisplatin.

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Section: Discussionsupporting

confidence: 90%

Hepatoprotective Effects of Opuntia dillenii Haw Fruit in a Mice Model of Lung Cancer

Shirazinia,

Sadeghi Hashjin,

Muhammadnejad

2023

Int J Basic Sci Med

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“…Additionally, the daily intake of the O. dillenii seed oil during four weeks does not induce a significant variation in the biochemical parameters and the body weight of rats while compared with the control group. Besides, the cell viability of HepG2 did not change in the presence of O. dillenii seed oil [59].…”

Section: Toxicology and Safety Of Opuntia Seed Oilsmentioning

confidence: 87%

Phytochemistry and biological activities of Opuntia seed oils: Opuntia dillenii (Ker Gawl.) Haw. and Opuntia ficus-indica (L.) Mill. A review

Bouknana

Ouassou

Boutahiri³

et al. 2021

Herba Polonica

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Summary Opuntia species belong to semi-arid and arid regions of Mexico and the United States. O. ficus-indica and O. dillenii are commonly used in alternative medicine to treat various diseases. Up to date, several scientific works have been carried out on the different parts of these plants. However, over the last few years, studies have been focusing on the oil obtained from the fruit seeds of these species. For this reason, this study aims to draw the attention of researchers toward the phytochemical and the pharmacological effects of these two Opuntia oils, which would help set up other scientific projects that promote these products. Phytochemical studies have shown that these oils are rich in biologically active molecules, such as unsaturated fatty acids and phytosterols (mainly linoleic acid and β-sitosterol), as well as vitamin E, which is represented only by the γ-tocopherol. Besides, these oils are rich in polyphenols that protect them from photo-oxidation. Moreover, several studies have shown their antioxidant, anti-diabetic, antibacterial, antifungal, anti-inflammatory, hepatoprotective, and gastroprotective activities, as well as their hypolipidemic properties. The beneficial effects of these oils include also their ability to block the weight loss, and what makes them more interesting is their safety, according to the literature.

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Opuntia dillenii (Ker Gawl.) Haw

Bastola

Poudel

Lamichhane

et al. 2023

Himalayan Fruits and Berries

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Acute and Subacute Toxicity and Cytotoxicity of Opuntia Dillenii (Ker-Gawl) Haw. Seed Oil and Its Impact on the Isolated Rat Diaphragm Glucose Absorption

Cited by 6 publications

References 26 publications

Hepatoprotective Effects of Opuntia dillenii Haw Fruit in a Mice Model of Lung Cancer

Hepatoprotective Effects of Opuntia dillenii Haw Fruit in a Mice Model of Lung Cancer

Phytochemistry and biological activities of Opuntia seed oils: Opuntia dillenii (Ker Gawl.) Haw. and Opuntia ficus-indica (L.) Mill. A review

Opuntia dillenii (Ker Gawl.) Haw

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