Acute Bacterial Meningitis

VanDemark, Michelle

doi:10.1016/j.ccell.2013.04.004

Cited by 18 publications

(12 citation statements)

References 31 publications

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“…Apparently, the entire original articles presenting cross-sectional studies on the prevalence and etiology of ABM in patients with suspected meningitis in Iran were considered. Diagnosis of meningitis in the included studies were performed by abnormal CSF findings, including: increased polymorphonuclear leukocytes counts, protein concentration more than 100 mg/dl and hypoglycorrhachia, and CSF culture as the gold standard method for detecting and identifying meningeal isolates [ 15 ]. Evidently, numerous studies were excluded from the analysis because of the following reasons: articles which only focused on individual etiological agent for meningitis; article which only considered sub-acute or chronic meningitis, those which only considered individual groups of patients such as HIV positive or immunocompromised patients, surveys which contained other infectious meningitis besides bacterial infections; such as, viral, fungal, and those papers which did not utilize the mentioned methods above; furthermore, reviews and systematic review articles, case reports, and articles which were only available in abstract form were excluded.…”

Section: Methodsmentioning

confidence: 99%

Acute bacterial meningitis in Iran: Systematic review and meta-analysis

et al. 2017

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IntroductionBacterial meningitis persists in being a substantial cause of high mortality and severe neurological morbidity, despite the advances in antimicrobial therapy. Accurate data has not been available regarding the epidemiology of bacterial meningitis particularly in developing countries, yet. Indeed, the present systematic review provides a comprehensive data analysis on the prevalence and epidemiology of bacterial meningitis in Iran.MethodsWe systematically reviewed articles from 1994 to 2015. The reports which contained the prevalence and etiology of acute bacterial meningitis by valid clinical and laboratory diagnosis were comprised in the present study.ResultsOur analysis indicated that Streptococcus pneumoniae (30% [I2 = 56% p < 0.01]), Haemophilus influenza type b (15% [I2 = 82.75% p < 0.001]), coagulase negative staphylococci (CoNS) (14% [I2 = 60.5% p < 0.06]), and Neisseria meningitidis (13% [I2 = 74.16% p < 0.001]) were the most common cause of acute bacterial meningitis among meningitis cases in Iran. Notably, high frequency rates of nosocomial meningitis pathogens were detected in the present analysis.ConclusionsIt was magnificently attained that the majority of cases for bacterial meningitis in Iran could be avertable by public immunization schemes and by preventive care to inhibit the broadening of hospital acquired pathogens.

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Section: Methodsmentioning

confidence: 99%

Acute bacterial meningitis in Iran: Systematic review and meta-analysis

et al. 2017

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“…NSC 34 38 and U251 39 cell-lines were used due to their neural origin. S. pneumoniae , Neisseria meningitidis and Haemophilus influenzae are the major bacterial pathogens causing meningitis, with S. pneumoniae being responsible for two thirds of meningitis cases in the developed world 54,55 . NSC 34 is a mouse neuroblastoma-spinal cord hybrid immortalized cell-line 38 , which has been used to study differentiation and characteristics of motor neuron 56,57 .…”

Section: Discussionmentioning

confidence: 99%

Streptococcus pneumoniae Cell Wall-Localized Trigger Factor Elicits a Protective Immune Response and Contributes to Bacterial Adhesion to the Host

Cohen

Troib

Dotan³

et al. 2019

Sci Rep

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Trigger factor (TF) has a known cytoplasmic function as a chaperone. In a previous study we showed that pneumococcal TF is also cell-wall localized and this finding combined with the immunogenic characteristic of TF, has led us to determine the vaccine potential of TF and decipher its involvement in pneumococcal pathogenesis. Bioinformatic analysis revealed that TF is conserved among pneumococci and has no human homologue. Immunization of mice with recombinant (r)TF elicited a protective immune response against a pneumococcal challenge, suggesting that TF contributes to pneumococcal pathogenesis. Indeed, rTF and an anti-rTF antiserum inhibited bacterial adhesion to human lung derived epithelial cells, indicating that TF contributes to the bacterial adhesion to the host. Moreover, bacteria lacking TF demonstrated reduced adhesion, in vitro, to lung-derived epithelial cells, neural cells and glial cells. The reduced adhesion could be restored by chromosomal complementation. Furthermore, bacteria lacking TF demonstrated significantly reduced virulence in a mouse model. Taken together, the ability of rTF to elicit a protective immune response, involvement of TF in bacterial adhesion, conservation of the protein among pneumococcal strains and the lack of human homologue, all suggest that rTF can be considered as a future candidate vaccine with a much broader coverage as compared to the currently available pneumococcal vaccines.

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“…( 5 ) Listeria monocytogenes is another etiologic agent, but its role in CABM is usually restricted to extremes of age and immunocompromised patients. ( 6 )…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors among critically ill patients with community-acquired acute bacterial meningitis and acute kidney injury

Filho¹,

Lima²,

Dantas³

et al. 2018

Revista Brasileira De Terapia Intensiva

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ObjectiveTo investigate prognostic factors among critically ill patients with community-acquired bacterial meningitis and acute kidney injury.MethodsA retrospective study including patients admitted to a tertiary infectious disease hospital in Fortaleza, Brazil diagnosed with community-acquired bacterial meningitis complicated with acute kidney injury. Factors associated with death, mechanical ventilation and use of vasopressors were investigated.ResultsForty-one patients were included, with a mean age of 41.6 ± 15.5 years; 56% were males. Mean time between intensive care unit admission and acute kidney injury diagnosis was 5.8 ± 10.6 days. Overall mortality was 53.7%. According to KDIGO criteria, 10 patients were classified as stage 1 (24.4%), 18 as stage 2 (43.9%) and 13 as stage 3 (31.7%). KDIGO 3 significantly increased mortality (OR = 6.67; 95%CI = 1.23 - 36.23; p = 0.028). Thrombocytopenia was not associated with higher mortality, but it was a risk factor for KDIGO 3 (OR = 5.67; 95%CI = 1.25 - 25.61; p = 0.024) and for mechanical ventilation (OR = 6.25; 95%CI = 1.33 - 29.37; p = 0.02). Patients who needed mechanical ventilation by 48 hours from acute kidney injury diagnosis had higher urea (44.6 versus 74mg/dL, p = 0.039) and sodium (138.6 versus 144.1mEq/L; p = 0.036).ConclusionMortality among critically ill patients with community-acquired bacterial meningitis and acute kidney injury is high. Acute kidney injury severity was associated with even higher mortality. Thrombocytopenia was associated with severer acute kidney injury. Higher urea was an earlier predictor of severer acute kidney injury than was creatinine.

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Acute Bacterial Meningitis

Cited by 18 publications

References 31 publications

Acute bacterial meningitis in Iran: Systematic review and meta-analysis

Acute bacterial meningitis in Iran: Systematic review and meta-analysis

Streptococcus pneumoniae Cell Wall-Localized Trigger Factor Elicits a Protective Immune Response and Contributes to Bacterial Adhesion to the Host

Prognostic factors among critically ill patients with community-acquired acute bacterial meningitis and acute kidney injury

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