Acute central serous chorioretinopathy: a correlation study between fundus autofluorescence and spectral-domain OCT

Iacono, Pierluigi; Battaglia, Parodi Maurizio; Papayannis, Alessandro; Spina, Carlo La; Varano, Monica; Bandello, Francesco

doi:10.1007/s00417-014-2899-5

Cited by 53 publications

(40 citation statements)

References 48 publications

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“…Focal areas of hypo-autofluorescence at the level of the leakage points are indeed observed in 70e100% of eyes with acute CSCR (Fig. 2D), which supports the hypothesis of a focal RPE defect or detachment of RPE cells at this site (Ayata et al, 2009;Eandi et al, 2005;Iacono et al, 2015;. In recurrent CSCR, the leakage point is usually different from previous episodes but locates in the vicinity of the first one, reflecting a barrier weakness persisting in this area.…”

Section: Fundus Autofluorescencesupporting

confidence: 74%

“…It may either return to normal, as observed in a majority of cases after SRD resolution (Iacono et al, 2015), or be progressively replaced by an increased FAF, as observed in episodes persisting more than 4 months (Framme et al, 2005). While the masking produced by the SRD and the elongated photoreceptor outer segments could explain the initial decrease in FAF (Fig.…”

Section: Fundus Autofluorescencementioning

confidence: 90%

“…Hyper-reflective dots frequently accumulate in the subretinal space below the detached neurosensory retina (Kon et al, 2008;Maruko et al, 2011a;Spaide and Klancnik, 2005) and within several retinal layers (Ahlers et al, 2009;Kon et al, 2008;Yalcinbayir et al, 2014). These dots, identified on SD-OCT, co-localize with hyper-autofluorescent area on FAF (Iacono et al, 2015;Maruko et al, 2011a;Spaide and Klancnik, 2005). As disease persists over time, the number of dots located in the subretinal space tends to increase (Wang et al, 2005) and correlates with worse final visual acuity (Landa et al, 2013, p. 201;Yalcinbayir et al, 2014).…”

Section: Spectral-domain Optical Coherence Tomographymentioning

confidence: 99%

“…elongated outer segments may account for the subsequent increased patchy FAF in the SRD area of non-resolving cases (Matsumoto et al, 2011). In addition, a residual granular increased FAF may remain visible after resolution and correlates with intraretinal hyper-reflective dots on SD-OCT (Iacono et al, 2015). It has been recently proposed that this residual granular hyperautofluorescence after CSCR resolution could originate from a loss of photoreceptor outer segments.…”

Section: Fundus Autofluorescencementioning

confidence: 99%

See 3 more Smart Citations

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

Daruich

Matet

Dirani

et al. 2015

Progress in Retinal and Eye Research

819

996

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Central serous chorioretinopathy (CSCR) is a major cause of vision threat among middle-aged male individuals. Multimodal imaging led to the description of a wide range of CSCR manifestations, and highlighted the contribution of the choroid and pigment epithelium in CSCR pathogenesis. However, the exact molecular mechanisms of CSCR have remained uncertain. The aim of this review is to recapitulate the clinical understanding of CSCR, with an emphasis on the most recent findings on epidemiology, risk factors, clinical and imaging diagnosis, and treatments options. It also gives an overview of the novel mineralocorticoid pathway hypothesis, from animal data to clinical evidences of the biological efficacy of oral mineralocorticoid antagonists in acute and chronic CSCR patients. In rodents, activation of the mineralocorticoid pathway in ocular cells either by intravitreous injection of its specific ligand, aldosterone, or by over-expression of the receptor specifically in the vascular endothelium, induced ocular phenotypes carrying many features of acute CSCR. Molecular mechanisms include expression of the calcium-dependent potassium channel (KCa2.3) in the endothelium of choroidal vessels, inducing subsequent vasodilation. Inappropriate or over-activation of the mineralocorticoid receptor in ocular cells and other tissues (such as brain, vessels) could link CSCR with the known co-morbidities observed in CSCR patients, including hypertension, coronary disease and psychological stress.

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Section: Fundus Autofluorescencesupporting

confidence: 74%

Section: Fundus Autofluorescencementioning

confidence: 90%

Section: Spectral-domain Optical Coherence Tomographymentioning

confidence: 99%

Section: Fundus Autofluorescencementioning

confidence: 99%

See 2 more Smart Citations

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

Daruich

Matet

Dirani

et al. 2015

Progress in Retinal and Eye Research

819

996

View full text Add to dashboard Cite

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“…During the initial presentation of CSCR, 72–96 % of cases show hypo-autofluorescence corresponding to the focal leakage site on fluorescein angiogram and to the area of serous retinal detachment, due to blockage by subretinal fluid [111–113]. A subset of patients may show localized RPE detachment, corresponding with focal hyper-autofluorescence.…”

Section: Central Serous Chorioretinopathymentioning

confidence: 99%

Clinical applications of fundus autofluorescence in retinal disease

2016

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Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the retinal pigment epithelium. Multiple commercially available imaging systems, including the fundus camera, the confocal scanning laser ophthalmoscope, and the ultra-widefield imaging device, are available to the clinician. Each offers unique advantages for evaluating various retinal diseases. The clinical applications of FAF continue to expand. It is now an essential tool for evaluating age related macular degeneration, macular dystrophies, retinitis pigmentosa, white dot syndromes, retinal drug toxicities, and various other retinal disorders. FAF may detect abnormalities beyond those detected on funduscopic exam, fluorescein angiography, or optical coherence tomography, and can be used to elucidate disease pathogenesis, form genotype-phenotype correlations, diagnose and monitor disease, and evaluate novel therapies. Given its ease of use, non-invasive nature, and value in characterizing retinal disease, FAF enjoys increasing clinical relevance. This review summarizes common ocular fluorophores, imaging modalities, and FAF findings for a wide spectrum of retinal disorders.

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Central Serous Chorioretinopathy/Pachychoroid Eye Diseases

Lee

2020

Macular Disorders

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Acute central serous chorioretinopathy: a correlation study between fundus autofluorescence and spectral-domain OCT

Abstract: The simultaneous acquisition of FAF and SD-OCT provides detailed findings of retinal abnormalities of CSCR and may help to understand the evolving process linked to CSCR.

Cited by 53 publications

References 48 publications

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

Clinical applications of fundus autofluorescence in retinal disease

Central Serous Chorioretinopathy/Pachychoroid Eye Diseases

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