Acute cerebellar ataxia with abnormal MRI lesions after varicella vaccination

Sunaga, Yasuo; Hikima, Akio; Ostuka, Takayuki; Morikawa, Akihiro

doi:10.1016/0887-8994(95)00194-8

Cited by 45 publications

(17 citation statements)

References 10 publications

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“…Imaging plays a modest role in diagnosis; T2 signal change of the cerebellum is widely documented [60, 61] but structural MRI findings maybe normal if patients are imaged early in the course of the illness [62, 63]. While SPECT perfusion has been reported as a potential diagnostic biomarker in the course of the illness, reports vary with both increased and decreased perfusion demonstrated alongside normal MR appearances of the cerebellum [62, 63].…”

Section: Section 5: Imaging In Immune-mediated Ataxiasmentioning

confidence: 99%

Consensus Paper: Radiological Biomarkers of Cerebellar Diseases

et al. 2014

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Hereditary and sporadic cerebellar ataxias represent a vast and still growing group of diseases whose diagnosis and differentiation cannot only rely on clinical evaluation. Brain imaging including magnetic resonance (MR) and nuclear medicine techniques allows for characterization of structural and functional abnormalities underlying symptomatic ataxias. These methods thus constitute a potential source of radiological biomarkers, which could be used to identify these diseases and differentiate subgroups of them, and to assess their severity and their evolution. Such biomarkers mainly comprise qualitative and quantitative data obtained from MR including proton spectroscopy, diffusion imaging, tractography, voxel-based morphometry, functional imaging during task execution or in a resting state, and from SPETC and PET with several radiotracers. In the current article, we aim to illustrate briefly some applications of these neuroimaging tools to evaluation of cerebellar disorders such as inherited cerebellar ataxia, fetal developmental malformations, and immune-mediated cerebellar diseases and of neurodegenerative or early-developing diseases, such as dementia and autism in which cerebellar involvement is an emerging feature. Although these radiological biomarkers appear promising and helpful to better understand ataxia-related anatomical and physiological impairments, to date, very few of them have turned out to be specific for a given ataxia with atrophy of the cerebellar system being the main and the most usual alteration being observed. Consequently, much remains to be done to establish sensitivity, specificity, and reproducibility of available MR and nuclear medicine features as diagnostic, progression and surrogate biomarkers in clinical routine.

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Section: Section 5: Imaging In Immune-mediated Ataxiasmentioning

confidence: 99%

Consensus Paper: Radiological Biomarkers of Cerebellar Diseases

et al. 2014

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“…The case clearly showed typical symptoms of MFS, which are of ophthalmoplegia with ataxia and areflexia 3 4. Positive antibody against GQ1, present in 90% of MFS, and neurophysiological finding also suggested diagnosis of MFS 5–7.…”

Section: Discussionmentioning

confidence: 89%

Miller Fisher syndrome linked to Norovirus infection

Shimizu

Tokuda

2012

BMJ Case Reports

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“…1 Most cases occur in the second year of life. 3 The pathophysiology of postinfectious acute cerebellar ataxia is poorly under-388 About half of the patients will have nystagmus.…”

Section: Postinfectious Acute Cerebellar Ataxiamentioning

confidence: 99%