Acute challenge ERP as a prognostic of stimulant therapy outcome in attention-deficit hyperactivity disorder

Effect of methylphenidate on auditory event related potential in boys with attention deficit hyperactivity disorder

“…Most of these studies reported decreased P3 amplitude in ADHD children in comparison to controls [8,11,12]. A number of these studies have also demonstrated increment or normalization of P3 amplitude with stimulant medication [13,14]. P3, latency on the other hand, has to some extent been less consistent [15].…”

Effects of Methylphenidate in Children with Attention Deficit Hyperactivity Disorder: A Comparison of Behavioral Results and Event–Related Potentials

“…Young ES, et al [13] used an auditory oddball P300 paradigm to compare the ERP changes preadministration and 2 hours post-administration of MPH. A prediction of the long-term benefit of medication was then made, based on the magnitude of the acute changes in P3b amplitude.…”

“…ERP analysis has been employed in efforts to gain knowledge about stimulant mechanisms and their relationship to appropriate effect, and studies have suggested that ERPs may predict the clinical response of children with ADHD to MPH [13]. Low dose MPH has been associated with reduced impulsivity (fewer false alarms) and decreased P3 latencies, whereas the higher doses have been associated with reduced impulsivity and less inattention (more hits), in addition to increased P2 and N2 latencies and decreased P3 latencies [14].…”

The Effects of Methylphenidate on Transcranial Magnetic Stimulation Parameters in Children with Attention Deficit Hyperactivity Disorder

“…Since MPH can not affect the axonal myelination such a short time, and since MPH did not affect CL, we speculate that the decrease in the CMCT may be imputed to increased information processing of cortical cells following MPH administration. Although previous studies suggested that information processing may be increased by MPH (28,31,32), further studies are warranted invastigating relationship between information processing and CMCT under the effect of MPH.…”

“…Since inhibitory responses were mostly induced by dopamine (26), we hypothesized that the MPH would increase the CSP in children with ADHD. Since it is believed that ADHD is associated with decreased information processing rate (27)(28)(29)(30) and MPH may be effective on impaired information processing in ADHD (28,31,32), we also hypothesized that MPH would decrease the CMCT in children with ADHD.…”