Acute Disseminated Lymphosarcoma with B Cell Markers in a Child

Abstract

A case of a 4-year-old child with disseminated lymphosarcoma with meningeal involvement is described. Immunological investigations of the blast cells in the cerebrospinal fluid were carried out and in most of them Ig determinants and no response to PHA stimulation were found. So the B-dependent nature of these cells was ascertained. This observation is a contribution to the diagnosis of lymphoid malignancies through the evaluation of the immunological nature of the blast cells. The data of the literature are still scarce and inconclusive.

Correlation of surface receptors with histological appearance in 29 cases of non-Hodgkin lymphoma

“…The plasma cells, or mature secretory B cells, have inconsistent surface markers, but contain intracytoplasmic Ig (Corte et al, 1976). We and others have found identical variations in the pattern of surface Ig, Fe and C3 receptors in human material such as normal peripheral blood (Habeshaw and Young, 1975), tonsil (Siegel, Grieco and Gupta, 1974), and in lymphomas (Brouet et al, 1975;Dorfman, 1975;Jaffe et al, 1975;Stuart and Habeshaw, 1976;Habeshaw and Stuart, 1975;Moscatelli, Bricarelli and Quartino, 1976). It therefore seems likely that the sequence of phenotype change seen in mature mouse B-lymphoid populations also occurs in man.…”

Nutrition, immunity and infection: From basic knowledge of dietary manipulation of immune responses to practical application of ameliorating suffering and improving survival

“…Would the immunologic abnormalities be reversible in young animals whose mothers had been subjected to a chronic nutritional insult before and͞or during gestation? Both in small-for-gestation low-birth-weight infants (26,27) and in animal models of intrauterine undernutrition or zinc deficiency (28,29), the immunologic impairment is profound and long lasting. What is the status of other immunologic mechanisms that play an important role in defense against intracellular pathogens, e.g., CD4…”

The Immunity of the Human Foetus and Newborn Infant

“…Ferguson et al (1974) found in these infants a significant decrease in the number of lymphocytes forming spontaneous rosettes (49.2 % ± 2.0 SD) as compared with normal neonates (65.1 % ± 1.4) and Chandra (1975) found, in their umbilical blood, T--lymphocyte suppression persisting up to the age of 3 months. Moscatelli et al ( 1976) also demonstrated a reduced relative and absolute T -lymphocyte count in the blood of low birthweight neonates (Fig. 65); in some cases they found that it was normalized during the first 3 -4 weeks of life, but in others, as mentioned above, it persisted for several months, indicating that deficient cellular immunity can be of a lasting nature in small-for-dates infants.…”

“…Some studies of cord blood B lymphoyctes with membrane immunoglobulins draw attention to their higher relative number compared with the blood of adults (Papamichail et al 1971, Moscatelli et al 1973 Immunol. In other words, neonates are presumably born with a full complement of this type of peripheral lymphocytes.…”

“…Recent studies unequivocally demonstrate T-lymphocyte deficiency in the peripheral blood of small-for-dates neonates, manifested in a decrease in both the relative (percentual) and the absolute count (Ferguson et al 1974, Chandra 1975, Moscatelli et al 1976, Hallberg and Hallberg 1977, Ferguson 1978. Ferguson et al (1974) found in these infants a significant decrease in the number of lymphocytes forming spontaneous rosettes (49.2 % ± 2.0 SD) as compared with normal neonates (65.1 % ± 1.4) and Chandra (1975) found, in their umbilical blood, T--lymphocyte suppression persisting up to the age of 3 months.…”