Abstract:Abstracf. The effect of two different single doses of a sustained release preparation of pyridyl carbinol, Ronicol Retard" taken by mouth, was studied in eleven patients. The results were compared to previously obtained data, with identical experimental procedures, for nicotinic acid and placebo.The concentration of free nicotinic acid in plasma rose slowly after 0.45 and 1.05 g of Ronicol Retard@ to reach a maximum level after 2 to 3 h and then declined to basal levels after 6 or more h.The concentration of F… Show more
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