Acute electrophysiologic effects of the polyphenols resveratrol and piceatannol in rabbit atria

Abstract

The natural polyphenol resveratrol and its analogue piceatannol have various beneficial effects including antiarrhythmic properties. The aim of the present study was to examine potential electrophysiologic effects in an experimental whole-heart model of atrial fibrillation (AF). Simultaneous infusion of resveratrol (50μM) or piceatannol (10μM) in rabbit hearts resulted in an increase of atrial refractory period. Both agents induced a significant slowing of atrial conduction and of intrinsic heart rate. In both groups, a trend towards a reduction of AF and a regularization of AF was observed. This article is protected by copyright. All rights reserved.

Resveratrol: an effective pharmacological agent to prevent inflammation-induced atrial fibrillation?

“…Resveratrol is a natural polyphenol derivative that has been widely investigated and is believed to have cardioprotective and antiarrhythmic properties (Baczko and Light 2015;Baczko et al 2014;Frommeyer et al 2018;Liu et al 2017;Trevino-Saldana and Garcia-Rivas 2017). Consistent with the findings by Zhang et al (2018), several studies have shown that resveratrol is also a promising pharmacological agent for the treatment of AF (Baczko and Light 2015).…”

“…It also inhibits phosphodiesterases, enhancing the inotropic effect of sympathomimetic agents, while inhibiting their proarrhythmic effects (Hernandez-Cascales 2017). Acute resveratrol treatment reduces the number of inducible AF episodes in an ex vivo rabbit AF model, without significant reduction in AF susceptibility (Frommeyer et al 2018). In this model, resveratrol induces slowing of intrinsic heart rate, Fig.…”

“…Resveratrol can alter cardiac electrophysiology and arrhythmogenesis through a direct effect on cardiac ion channels, including inhibition of the peak and late components of cardiac voltage-gated Na + channels (Baczko and Light 2015;Frommeyer et al 2018). Resveratrol increases myofilament Ca 2+ sensitivity but inhibits L-type Ca 2+ currents, resulting in a decreased Ca 2+ transient amplitude (Liu et al 2017).…”

Antioxidants in Arrhythmia Treatment—Still a Controversy? A Review of Selected Clinical and Laboratory Research

“…RSV induced a prolongation of the atrial effective refractory period and slowed conduction velocity, which is a critical antiarrhythmic mechanism. A study on rabbit hearts demonstrated that RSV and piceatannol (a derivative of RSV) reduce AF incidence after administration of acetylcholine and isoproterenol [ 59 ]. Thus, RSV and vitamins C and E can improve the outcomes of patients with supraventricular and ventricular arrhythmias, including those in a critical condition, with risk factors and with diseases resulting in myocardial remodelling and structural changes.…”

A Novel Computational Model of the Rabbit Atrial Cardiomyocyte With Spatial Calcium Dynamics

“…While animal models remain the primary source of experimental data on ion channels and electrical activity in the heart, computational models of different animal species constitute an important tool for knowledge extraction and translation between species. The rabbit has been a particularly useful animal model to study different aspects of cardiac electrophysiology and arrhythmia, given the similarities of their electrophysiological properties to the human (Ravelli and Allessie, 1997 ; Eijsbouts et al, 2003 ; Rouge et al, 2006 ; Greiser et al, 2014 ; Li et al, 2014 ; Wang et al, 2017 ; Frommeyer et al, 2019 ). The wide application of the experimental rabbit model has motivated the development of rabbit-specific mathematical models of cardiomyocyte (CM) electrophysiology (see e.g., Hilgemann and Noble, 1987 ; Demir et al, 1994 , 1999 ; Lindblad et al, 1996 ; Kurata et al, 2002 ; Shannon et al, 2004 ; Mahajan et al, 2008 ; Aslanidi et al, 2009 ; Maltsev and Lakatta, 2009 ), which incorporate rabbit-specific formulations of ionic currents.…”