Acute generalized exanthematous pustulosis due to dextromethorphan

Rashid, Rabia Sofia; Ahmed, Imtiaz; Shim, Tang Ngee

doi:10.1111/cod.13633

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Cited by 4 publications

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“…Moreover, our observation is notable for the implication of dextromethorphan, a widely used opioid antitussive agent, as a culprit drug. To the best of our knowledge, only 1 case of AGEP induced by dextromethorphan and confirmed by patch testing has been previously reported [2]. marked neutrophilia and skin biopsy was consistent with AGEP.…”

Section: Discussionmentioning

confidence: 74%

Recurrent acute generalized exanthematous pustulosis to two different drugs: Oxacillin and Dextromethorphan confirmed by patch test

Kenani

Gammoudi

Fathallah³

et al. 2022

Dermatol Pract Concept

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Section: Discussionmentioning

confidence: 74%

Recurrent acute generalized exanthematous pustulosis to two different drugs: Oxacillin and Dextromethorphan confirmed by patch test

Kenani

Gammoudi

Fathallah³

et al. 2022

Dermatol Pract Concept

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Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management

et al. 2023

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Acute generalized exanthematous pustulosis (AGEP) is a rare, acute, severe cutaneous adverse reaction mainly attributed to drugs, although other triggers, including infections, vaccinations, ingestion of various substances, and spider bites, have also been described. AGEP is characterized by the development of edema and erythema followed by the eruption of multiple punctate, non-follicular, sterile pustules and subsequent desquamation. AGEP typically has a rapid onset and prompt resolution within a few weeks. The differential diagnoses for AGEP are broad and include infectious, inflammatory, and drug-induced etiologies. Diagnosis of AGEP depends on both clinical and histologic criteria, as cases of overlap with other disease processes have been reported. Management includes removal of the offending drug or treatment of the underlying cause, if necessary, and supportive care, as AGEP is a self-limited disease. This review aims to provide an overview and update on the epidemiology, pathogenesis, reported precipitating factors, differentials, diagnosis, and management of AGEP.

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Paracetamol/promethazine/dextromethorphan

2020

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Acute generalized exanthematous pustulosis due to dextromethorphan

Cited by 4 publications

References 1 publication

Recurrent acute generalized exanthematous pustulosis to two different drugs: Oxacillin and Dextromethorphan confirmed by patch test

Recurrent acute generalized exanthematous pustulosis to two different drugs: Oxacillin and Dextromethorphan confirmed by patch test

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management

Paracetamol/promethazine/dextromethorphan

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