Acute Generalized Exanthematous Pustulosis due to Teicoplanin

Chu, Chia-Yu; Wu, June‐Tai; Jean, Shio Shin; Sun, Chee Ching

doi:10.1159/000051617

Cited by 18 publications

(6 citation statements)

References 14 publications

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“…Red man syndrome is very unusual with teicoplanin because this compound does not cause histamine release even at faster infusion rates than those of vancomycin. Immediate reactions [anaphylaxis86,87] and non-immediate reactions [rash,88 AGEP89 and DHS90] are infrequent. Although there have been reports of cross-reactivity between individuals with vancomycin and teicoplanin allergy,91-95 there have also been reports of patients with teicoplanin who tolerated vancomycin 96,97…”

Section: Vancomycin and Teicoplanin Allergymentioning

confidence: 99%

Update on the Management of Antibiotic Allergy

Thong

2010

Allergy Asthma Immunol Res

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Drug allergy to antibiotics may occur in the form of immediate or non-immediate (delayed) hypersensitivity reactions. Immediate reactions are usually IgE-mediated whereas non-immediate hypersensitivity reactions are usually non-IgE or T-cell mediated. The clinical manifestations of antibiotic allergy may be cutaneous, organ-specific (e.g., blood dyscracias, hepatitis, interstitial nephritis), systemic (e.g., anaphylaxis, drug induced hypersensitivity syndrome) or various combinations of these. Severe cutaneous adverse reactions manifesting as Stevens Johnson syndrome or toxic epidermal necrolysis (TEN) may be potentially life-threatening. The management of antibiotic allergy begins with the identification of the putative antibiotic from a detailed and accurate drug history, complemented by validated in-vivo and in-vitro allergological tests. This will facilitate avoidance of the putative antibiotic through patient education, use of drug alert cards, and electronic medical records with in-built drug allergy/adverse drug reaction prescription and dispensing checks. Knowledge of the evidence for specific antibiotic cross-reactivities is also important in patient education. Apart from withdrawal of the putative antibiotic, immunomodulatory agents like high-dose intravenous immunoglobulins may have a role in TEN. Drug desensitization where the benefits outweigh the risks, and where no alternative antibiotics can be used for various reasons, may be considered in certain situations. Allergological issues pertaining to electronic drug allergy alerts, computerized physician prescriptions and decision support systems, and antibiotic de-escalation in antimicrobial stewardship programmes are also discussed.

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Section: Vancomycin and Teicoplanin Allergymentioning

confidence: 99%

Update on the Management of Antibiotic Allergy

Thong

2010

Allergy Asthma Immunol Res

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“…described a case of teicoplanin‐induced toxicodermia in 1994 in the Spanish literature. Recently, Chu et al 7 . reported a case with acute generalized exanthematous pustulosis due to teicoplanin.…”

Section: Discussionmentioning

confidence: 99%

Teicoplanin‐induced skin eruption

Ünal¹,

İkizoğlu²,

Demirkan³

et al. 2002

Int J Dermatology

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“…SJS, exfoliative dermatitis, TEN, extensive drug fixed eruption, and leukocytoclastic vasculitis have all been described in association with vancomycin use in case reports. Other forms of hypersensitivity include DiHS syndrome/DRESS, AGEP, linear IgA bullous dermatosis and renal disorders [ 215 , 221 – 226 ].…”

Section: Vancomycinmentioning

confidence: 99%

Hypersensitivity reactions to non beta-lactam antimicrobial agents, a statement of the WAO special committee on drug allergy

Sánchez‐Borges

Thong

Blanca

et al. 2013

World Allergy Organization Journal

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Antibiotics are used extensively in the treatment of various infections. Consequently, they can be considered among the most important agents involved in adverse reactions to drugs, including both allergic and non-allergic drug hypersensitivity [J Allergy Clin Immunol 113:832–836, 2004]. Most studies published to date deal mainly with reactions to the beta-lactam group, and information on hypersensitivity to each of the other antimicrobial agents is scarce. The present document has been produced by the Special Committee on Drug Allergy of the World Allergy Organization to present the most relevant information on the incidence, clinical manifestations, diagnosis, possible mechanisms, and management of hypersensitivity reactions to non beta-lactam antimicrobials for use by practitioners worldwide.

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Acute Generalized Exanthematous Pustulosis due to Teicoplanin

Cited by 18 publications

References 14 publications

Update on the Management of Antibiotic Allergy

Update on the Management of Antibiotic Allergy

Teicoplanin‐induced skin eruption

Hypersensitivity reactions to non beta-lactam antimicrobial agents, a statement of the WAO special committee on drug allergy

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