Acute Hemorrhagic Cystitis Caused by Adenovirus Type 11 after Renal Transplantation

Shindo, Kazuhiko; Kitayama, Toshio; Ura, Toshio; Matsuya, Fukuzo; Kusaba, Yasuyuki; Kanetake, Hiroshi; Saito, Yutaka

doi:10.1159/000281186

Cited by 28 publications

(20 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adll has been reported to be associated with upper or lower respiratory illness [10,[17][18][19], hemorrhagic cystitis in chil dren and young adults, especially in renal transplant recipients [7,8,[20][21][22][23][24], and ep idemic hemorrhagic conjunctivitis [25,26].…”

Section: Discussionmentioning

confidence: 99%

Genetic Relationship between Thirteen Genome Types of Adenovirus 11, 34, and 35 with Different Tropisms

Hambraeus

Wadell

1991

Intervirology

View full text Add to dashboard Cite

Eleven genome types of adenovirus serotype 11 (Adll) were identified among 20 strains isolated from healthy pregnant women and patients with urinary tract infections, respiratory tract infections, or pharyngoconjuctival fever by use of 13 restriction endonuc-leases: BamHl, Bell, BglI, BglII, BstEII, EcoRl, Hindlll, Hpal, Pstl, SalI, Smal, Xbal, and Xhol. All genome types could be grouped into three genomic clusters according to their genetic homology expressed as pairwise comigrating restriction fragments. The genome types within a genomic cluster were very closely related. They shared on an average pairwise comigrating restriction fragments of 91.6–97.7%. The Adll strains of genomic clusters 1 and 3 were isolated from urine, whereas all the Ad11 strains isolated from the respiratory tract were identified as members of the genomic cluster 2. One genome type of Ad34 and one genome type of Ad35 were identified from a hemorrhagic cystitis patient and an organ transplant recipient, respectively. Both were closely related to Adll. The genome type of Ad35 could be located in the Ad11 genomic cluster 1.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic Relationship between Thirteen Genome Types of Adenovirus 11, 34, and 35 with Different Tropisms

Hambraeus

Wadell

1991

Intervirology

View full text Add to dashboard Cite

show abstract

“…Conversely, if the recipient had no antibody to the infecting virus but the donor did, the serologic data suggest that the virus was latent in the donor organ and proceeded to set up a new infection in the recipient. In LT (67,122) and RT (39,46,64,76,87,91,107,113) recipients, this has been the case more often than infection from reactivated endogenous virus.…”

Section: Adenoviruses In Primary Immunodeficienciesmentioning

confidence: 99%

Adenoviruses in the immunocompromised host

1992

View full text Add to dashboard Cite

Adenoviruses are among the many pathogens and opportunistic agents that cause serious infection in the congenitally immunocompromised, in patients undergoing immunosuppressive treatment for organ and tissue transplants and for cancers, and in human immunodeficiency virus-infected patients. Adenovirus infections in these patients tend to become disseminated and severe, and the serotypes involved are clustered according to the age of the patient and the nature of the immunosuppression. Over 300 adenovirus infections in immunocompromised patients, with an overall case fatality rate of 48%, are reviewed in this paper. Children with severe combined immunodeficiency syndrome and other primary immunodeficiencies are exposed to the serotypes of subgroups B and C that commonly infect young children, and thus their infections are due to types 1 to 7 and 31 of subgenus A. Children with bone marrow and liver transplants often have lung and liver adenovirus infections that are due to an expanded set of subgenus A, B, C, and E serotypes. Adults with kidney transplants have viruses of subgenus B, mostly types 11, 34, and 35, which cause cystitis. This review indicates that 11% of transplant recipients become infected with adenoviruses, with case fatality rates from 60% for bone marrow transplant patients to 18% for renal transplant patients. Patients with AIDS become infected with a diversity of serotypes of all subgenera because their adult age and life-style expose them to many adenoviruses, possibly resulting in antigenically intermediate strains that are not found elsewhere. Interestingly, isolates from the urine of AIDS patients are generally of subgenus B and comprise types 11, 21, 34, 35, and intermediate strains of these types, whereas isolates from stool are of subgenus D and comprise many rare, new, and intermediate strains that are untypeable for practical purposes. It has been estimated that adenoviruses cause active infection in 12% of AIDS patients and that 45% of these infections terminate in death within 2 months. In all immunocompromised patients, generalized illness involving the central nervous system, respiratory system, hepatitis, and gastroenteritis usually have a fulminant course and result in death. Treatments for adenovirus infections are of little proven value, although certain purine and pyrimidine analogs have shown beneficial effects in vitro and may be promising drugs.

show abstract

“…Ad11, belonging to the species B adenoviruses, was originally isolated from the urinary tract and causes hemorrhagic cystitis in children (Numazaki et al, 1968;Shindo et al, 1986). We have previously shown that species B adenoviruses use two different receptors (Mei et al, 1998;Segerman et al, 2003a).…”

Section: Introductionmentioning

confidence: 99%

Replication-Competent Ad11p Vector (RCAd11p) Efficiently Transduces and Replicates in Hormone-Refractory Metastatic Prostate Cancer Cells

Sandberg

Papareddy²,

Silver³

et al. 2009

Human Gene Therapy

View full text Add to dashboard Cite

Selective replication-competent adenovirus serotype 5 vectors have been used for prostate cancer therapy. Unfortunately, gene transfer is inefficient because hormone-refractory metastatic prostate cancer cells have minimal coxsackievirus-adenovirus receptor expression. Vectors based on species B adenoviruses are attractive tools for use in human gene therapy because the viruses have low seroprevalence and they have efficient transduction capacity. Most species B adenoviruses use ubiquitously expressed complement-regulatory CD46 protein as a cellular receptor. Here we report the transduction efficacy and oncolytic capacity of a replication-competent Ad11p (RCAd11p) vector in human prostate cancer cells. Green fluorescent protein was efficiently expressed in a dose-dependent manner in PC-3 and DU 145 cells derived from metastasis of prostate cancer to bone and brain, respectively. However, transduction was less effective in LNCaP cells derived from prostate cancer metastasis to lymph nodes. The oncolytic capacity of the RCAd11p vector was 100 times higher in PC-3 cells than in the two other cell lines. The oncolysis was independent of the level of expression of p53 in the cells or on the absence of E1B55k expression in the vector. In vivo experiments revealed significant growth inhibition of PC-3 tumors in the xenograft mouse group treated with RCAd11p vector or Ad11pwt in comparison with the untreated control group. Thus, we have demonstrated that RCAd11p vector intrinsically possesses oncolytic properties, which were active in targeting tumor cells. Consequently, the novel RCAd11p vector has great potential for the treatment of incurable metastatic prostate disease.

show abstract

Acute Hemorrhagic Cystitis Caused by Adenovirus Type 11 after Renal Transplantation

Cited by 28 publications

References 7 publications

Genetic Relationship between Thirteen Genome Types of Adenovirus 11, 34, and 35 with Different Tropisms

Genetic Relationship between Thirteen Genome Types of Adenovirus 11, 34, and 35 with Different Tropisms

Adenoviruses in the immunocompromised host

Replication-Competent Ad11p Vector (RCAd11p) Efficiently Transduces and Replicates in Hormone-Refractory Metastatic Prostate Cancer Cells

Contact Info

Product

Resources

About