Acute hepatic failure due to hepatosplenic B-cell non-Hodgkin's lymphoma in a patient infected with hepatitis C virus

Yoshikawa, Masahide; Yamane, Yoshiko; Yoneda, Satoshi; Iwasawa, Shu; Nishimura, Kimio; Kawamoto, Hiroshi; Nakano, Hiroshi; Fukui, Hiroshi; Nakamine, Hirokazu

doi:10.1007/s005350050193

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…Primary hepatosplenic diffuse large B-cell lymphoma associated with HCV has been reported [112], and fetal acute liver failure can also occur [113]. Although the etiological role of HCV in lymphoma is unknown, HCV-positive lymphomas tend to arise in extranodal sites, especially in the liver, spleen, or salivary glands where HCV resides and chronic infiltration of lymphocytes occurs.…”

Section: Lymphoid Neoplasmsmentioning

confidence: 99%

Hepatic Manifestations in Hematological Disorders

Murakami

Shimizu

2013

International Journal of Hepatology

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Liver involvement is often observed in several hematological disorders, resulting in abnormal liver function tests, abnormalities in liver imaging studies, or clinical symptoms presenting with hepatic manifestations. In hemolytic anemia, jaundice and hepatosplenomegaly are often seen mimicking liver diseases. In hematologic malignancies, malignant cells often infiltrate the liver and may demonstrate abnormal liver function test results accompanied by hepatosplenomegaly or formation of multiple nodules in the liver and/or spleen. These cases may further evolve into fulminant hepatic failure.

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Section: Lymphoid Neoplasmsmentioning

confidence: 99%

Hepatic Manifestations in Hematological Disorders

Murakami

Shimizu

2013

International Journal of Hepatology

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“…Although there are several reports of cases of hepatic or splenic primary lymphomas as separate entities, primary hepatosplenic lymphomas represent a rare entity, and the majority of cases reported have been of T-cell origin, especially the γ/δ subtype [3], although the presentation of primary hepatosplenic DLBCL is limited to the four cases analyzed in this paper (tables 1 and 2) [4, 5, 6], including our own case. Considering the small number of patients, it is not possible to establish definitive conclusions.…”

Section: Discussionmentioning

confidence: 94%

“…Two of the cases analyzed (cases 1 and 3) (table 2) had a similar course and both had positive serology for hepatitis C virus. The exact mechanism responsible for the association between hepatitis C virus and such an aggressive lymphoma is partially unknown [6, 7]. …”

Section: Discussionmentioning

confidence: 99%

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Primary Hepatosplenic Large B-Cell Lymphoma

Morales-Polanco

Drijansky-Morgenstern

Murillo-Meza

et al. 2008

Case Rep Gastroenterol

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Diffuse large B-cell lymphoma is the most common form of lymphoma. It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas limited to liver or spleen as separate entities, and to date there have been only three documented cases of primary hepatosplenic presentation. This paper reports a fourth case. Due to a review of the literature and the clinical course of the case reported, we conclude that primary hepatosplenic large B-cell lymphoma has been found predominantly in females older than 60 years. The patients reported had <2 months of evolution prior to diagnosis, prominent B symptoms, splenomegaly in three and hepatomegaly in two, none with lymph node involvement. All had thrombocytopenia and abnormal liver function tests; three had anemia and elevated serum lactic dehydrogenase levels, two with hemophagocytosis in bone marrow. Because of the previously mentioned data, it can be stated that primary hepatosplenic lymphoma is an uncommon and aggressive form of disease that requires immediate recognition and treatment.

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“…Hodgkin and non-Hodgkin lymphomas, acute leukemias, and transformation of chronic leukemias to acute stages have all been associated with sporadic cases of acute liver failure [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] . The important step in the diagnosis of such pathologies is a liver biopsy once other obstructive, toxic, and infective causes of liver failure have been ruled out by laboratory tests and imaging studies.…”

Section: Discussionmentioning

confidence: 99%

Acute Liver Failure Because of Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

et al. 2011

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Infiltration of the liver by hematologic malignancies is an uncommon cause of liver failure. B-Cell chronic lymphocytic leukemia (CLL) is a usually indolent disease that may infiltrate the liver, but based on a review of the literature, has never been reported to induce acute liver failure. Here, we describe the case of a 78-year-old woman with acute liver failure secondary to infiltration with CLL being unresponsive to chemotherapy and causing death. This case is notable because of its atypical presentation and ultimate poor prognosis.

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Acute hepatic failure due to hepatosplenic B-cell non-Hodgkin's lymphoma in a patient infected with hepatitis C virus

Cited by 11 publications

References 24 publications

Hepatic Manifestations in Hematological Disorders

Hepatic Manifestations in Hematological Disorders

Primary Hepatosplenic Large B-Cell Lymphoma

Acute Liver Failure Because of Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

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