Acute hepatitis associated with an echovirus 9 infection in a heart transplant recipient

Abstract

Human enteroviruses (HEVs) belong to the very diverse Picornaviridae family and are categorized according to their species and genotypes. 1 Clinically, HEVs cause mostly asymptomatic or mild disease in immunocompetent adults, but severe and chronic forms have been described in immunocompromised patients. 2 Factors associated with these severe enteroviral diseases include B-cell depletion that occurs especially during severe combined immunodeficiency or anti-CD20 therapy, 3,4 and organ/tissue transplantations. 5 While severe forms of enterovirus infection with