Acute hepatitis C infection with evidence of heterosexual transmission

Nguyen, Oanh Kieu; Sheppeard, Vicky; Douglas, Mark W.; Tu, Elise; Rawlinson, William D.

doi:10.1016/j.jcv.2010.06.008

Cited by 15 publications

(5 citation statements)

References 18 publications

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“…Even though the vast majority of sexually transmitted AHC infections has been reported among HIV-positive MSM, acute HCV infections have also been observed in HIV-negative MSM 36 and heterosexual couples. 37 In contrast to HIV-positive patients who are seen every 3 to 6 months for routine control of HIV infection, HIV-negative patients may consult with their general practitioner on a lessfrequent basis, thus acute liver transaminase elevations and diagnosis of asymptomatic acute HCV infection may possibly be missed in the HIV-negative population. Therefore, a certain degree of underreporting must be acknowledged, which may DOI http://dx.doi.org/ 10.1055/s-0032-1316468.…”

Section: Epidemiologymentioning

confidence: 99%

Acute Hepatitis C in Patients with HIV

Boesecke

Rockstroh

2012

Semin Liver Dis

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Almost 10 years ago clinicians started to note the first cases of an outbreak of acute hepatitis C (AHC) infections among human immunodeficiency virus- (HIV-) positive men who have sex with men (MSM) in Europe, soon followed by similar reports from the United States and Australia. In the absence of randomized controlled treatment trials in AHC, coinfection expert consensus recommendations based upon published data from uncontrolled clinical and cohort studies give guidance on best clinical management. Pegylated interferon in combination with weight-adapted ribavirin is still recommended as the treatment of choice for all HCV genotypes. For patients developing a rapid virologic response, treatment duration of 24 weeks is recommended. If antiviral therapy was initiated within 24 weeks after diagnosis, high sustained virologic response rates of 60 to 80% have been observed. Prevention and screening efforts along with early anti-HCV therapy have to be intensified to allow for control of viral dissemination as the current epidemic of AHC particularly among MSM is still ongoing.

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Section: Epidemiologymentioning

confidence: 99%

Acute Hepatitis C in Patients with HIV

Boesecke

Rockstroh

2012

Semin Liver Dis

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“…Furthermore, the results of phylogenetic analyses suggested that interspousal HCV infection occurred in the three couples. As previously reported, 12,13 the usefulness of phylogenetic analysis of nucleotide sequences of HCV E1 region for clarifying interspousal HCV infection was validated.…”

Section: Discussionmentioning

confidence: 82%

“…Actually the case of acute hepatitis C, who acquired HCV during an accidental or opportunistic vaginal sexual liaison was reported. 13 The case was in the absence of ongoing co-habitation, in the absence of bleeding or laceration during intercourse. She was a 62-year-old woman and acquired acute hepatitis C virus infection after heterosexual contact with a known HCV positive man.…”

Section: Resultsmentioning

confidence: 99%

“…The presence of HCV in semen and cervical smears might establish sexual transmission of HCV. Actually the case of acute hepatitis C, who acquired HCV during an accidental or opportunistic vaginal sexual liaison was reported 13 . The case was in the absence of ongoing co‐habitation, in the absence of bleeding or laceration during intercourse.…”

Section: Discussionmentioning

confidence: 99%

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Clarification of interspousal hepatitis C virus infection in acute hepatitis C patients by molecular evolutionary analyses: Consideration on sexual and non‐sexual transmission between spouses

Nakamura

Tanaka

Ochiai

et al. 2011

Hepatology Research

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“…Confirmation that a horizontal transmission event has occurred could be demonstrated by a high homology between the respective HCV genomes. Nevertheless, few of the previous studies included phylogenetic analysis [ 48 – 51 ] and sequence comparison was done only on the consensus sequence level [ 5 , 51 – 53 ].…”

Section: Discussionmentioning

confidence: 99%

Spouse-to-Spouse Transmission and Evolution of Hypervariable Region 1 and 5’ Untranslated Region of Hepatitis C Virus Analyzed by Next-Generation Sequencing

et al. 2016

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Hepatitis C virus (HCV) transmission between spouses remains poorly characterized, largely due to the limited availability of samples from the early stage of infection, as well as methodological constraints. A fifty-eight year-old male developed acute hepatitis C infection and his 53-year old spouse has been HCV-positive for over 10 years. Serum samples were collected from both at the time of acute hepatitis C diagnosis in male (baseline) and then at 9 and 13 months. Hypervariable region 1 (HVR1) and 5’ untranslated region (5’UTR) sequences were amplified and subjected to next generation sequencing (NGS) using a pyrosequencing platform. Genetic variants were inferred by Shorah reconstruction method and compared by phylogenetic and sequence diversity analysis. As the sequencing error of the procedure was previously determined to be ≤ 1.5%, the analysis was conducted with and without the 1.5% cut-off with regard to the frequency of variants. No identical HVR1 variants were identified in spouses at baseline and follow-up samples regardless whether the cut-off was applied or not. However, there was high similarity (98.3%) between a minor baseline donor variant (1.7% frequency) and the most abundant baseline recipient variant (62.5% frequency). Furthermore, donor and recipient strains clustered together when compared to 10 control subjects from the same area and infected with the same HCV subtype. There was an increase in HVR1 complexity (number of genetic variants) over time in both spouses. In contrast, the 5'UTR region was stable and of low complexity throughout the study. In conclusion, intrafamilial HCV transmission may be established by a very minor variant and investigation of this phenomenon requires high-sensitivity assays, such as NGS.

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Acute hepatitis C infection with evidence of heterosexual transmission

Cited by 15 publications

References 18 publications

Acute Hepatitis C in Patients with HIV

Acute Hepatitis C in Patients with HIV

Clarification of interspousal hepatitis C virus infection in acute hepatitis C patients by molecular evolutionary analyses: Consideration on sexual and non‐sexual transmission between spouses

Spouse-to-Spouse Transmission and Evolution of Hypervariable Region 1 and 5’ Untranslated Region of Hepatitis C Virus Analyzed by Next-Generation Sequencing

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