Acute hepatitis induced by greater celandine (Chelidonium majus)

Benninger, J.; Schneider, H. T.; Schuppan, Detlef; Kirchner, Thomas; Hahn, Eckhart G.

doi:10.1016/s0016-5085(99)70410-5

Cited by 146 publications

(82 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Retrospective assessment of unintentional reexposure tests is cumbersome, because clinical conditions are variable, as shown in the present report (Tables 1 and 4) [1][2][3][4][5] and in previous case analyses [14,[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] . Specific criteria for reexposure tests are available since 1988 (Table 3) [31] and have been incorporated in the CIOMS scale (Table 4) [16,32,34] following successful use for validation purposes [33] .…”

Section: Discussionmentioning

confidence: 78%

“…Data problems of reexposure cases are not confined to Herbalife products (Table 4) but represent a general problem extending to liver injury by all herbal drugs, dietary supplements and herbal products [14,[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] . Analysis of 30 cases within the last three decades claiming a positive reexposure test revealed that in many cases detailed descriptions of the reexposure test and actual ALT values were lacking.…”

Section: Items For Hepatocellular Type Of Injurymentioning

confidence: 99%

“…In retrospect, a positive reexposure test has been confirmed in only 13/30 cases (43%) [16] , as ascertained by established criteria published previously [31] . Of note, none of these reports communicated criteria for the evaluation of the observed reexposure test [14,16,[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] . The use of inappropriate causality assessment methods in the analyzed case reports is difficult to reconcile [1][2][3][4][5] .…”

Section: Items For Hepatocellular Type Of Injurymentioning

confidence: 99%

See 2 more Smart Citations

Herbalife hepatotoxicity: Evaluation of cases with positive reexposure tests

Teschke¹,

Frenzel²,

Schulze³

et al. 2013

WJH

View full text Add to dashboard Cite

AIM:To analyze the validity of applied test criteria and causality assessment methods in assumed Herbalife hepatotoxicity with positive reexposure tests. METHODS:We searched the Medline database for suspected cases of Herbalife hepatotoxicity and retrieved 53 cases including eight cases with a positive unintentional reexposure and a high causality level for Herbalife. First, analysis of these eight cases focused on the data quality of the positive reexposure cases, requiring a baseline value of alanine aminotransferase (ALT) < 5 upper limit of normal (N) before reexposure, with N as the upper limit of normal, and a doubling of the ALT value at reexposure as compared to the ALT value at baseline prior to reexposure. Second, reported methods to assess causality in the eight cases were evaluated, and then the liver specific Council for International Organizations of Medical Sciences (CIOMS) scale validated for hepatotoxicity cases was used for quantitative causality reevaluation. This scale consists of various specific elements with scores provided through the respective case data, and the sum of the scores yields a causality grading for each individual case of initially suspected hepatotoxicity. RESULTS:Details of positive reexposure test conditions and their individual results were scattered in virtually all cases, since reexposures were unintentional and allowed only retrospective rather than prospective assessments. In 1/8 cases, criteria for a positive reexposure were fulfilled, whereas in the remaining cases the reexposure test was classified as negative (n = 1), or the data were considered as uninterpretable due to missing information to comply adequately with the criteria (n = 6). In virtually all assessed cases, liver unspecific causality assessment methods were applied rather than a liver specific method such as the CIOMS scale. Using this scale, causality gradings for Herbalife in these eight cases were probable (n = 1), unlikely (n = 4), and excluded (n = 3). Confounding variables included low data quality, alternative diagnoses, poor exclusion of important other causes, and comedication by drugs and herbs in 6/8 cases. More specifically, problems were evident in some cases regarding temporal association, daily doses, exact start and end dates of product use, actual data of laboratory parameters such as ALT, and exact dechallenge characteristics. Shortcomings included scattered exclusion of hepatitis A-C, cytomegalovirus and Epstein Barr virus infection with only globally presented or lacking parameters. Hepatitis E virus infection was considered in one single patient and found positive, infections by herpes simplex ORIGINAL ARTICLE

show abstract

Section: Discussionmentioning

confidence: 78%

Section: Items For Hepatocellular Type Of Injurymentioning

confidence: 99%

Section: Items For Hepatocellular Type Of Injurymentioning

confidence: 99%

See 1 more Smart Citation

Herbalife hepatotoxicity: Evaluation of cases with positive reexposure tests

Teschke¹,

Frenzel²,

Schulze³

et al. 2013

WJH

View full text Add to dashboard Cite

show abstract

“…An aqueous extract inhibited NOTE. Data are selected from Larrey and Pageaux, 5 Kaplowitz, 6 Benninger et al, 9 and Yoshida et al 4 woodchuck hepatitis virus DNA polymerase and surface antigen expression 17,18 and several protein kinases such as cAMP-dependent protein kinase, protein kinase C, and myosin light-chain kinase in rat liver. 19 A nonrandomized clinical study showed a remarkable 59% (22 of 37 patients) clearance of HBsAg in chronic carriers who were treated for 30 days compared with only 4% (1 of 23 patients) given placebo.…”

Section: Studies Of Defined Formulations Of Herbal Medicinesmentioning

confidence: 99%

Herbal products for liver diseases: A therapeutic challenge for the new millennium

et al. 1999

Self Cite

View full text Add to dashboard Cite

“…They were also exploited to treat liver disorders and fight fever. Chelidonium majus preparations have been frequently prescribed to treat gastric and biliary disorders, and irritable bowel syndrome [20]. In traditional Chinese medicine the plant is used as an antitussive, to treat whooping cough and bronchitis.…”

Section: Introductionmentioning

confidence: 99%